The study of normal pregnancy in women with hereditary thrombophilia
https://doi.org/10.17749/2070-4968.2015.9.2.006-012
Abstract
Objective: The definition of the conditions under which women with inherited thrombophilia can have a positive pregnancy outcome. Materials and Methods. We conducted a retrospective and partially prospective analysis of 100 women with various forms of hereditary thrombophilia with the purpose of studying the conditions of a positive outcome of pregnancy. Results. We learned that normal uncomplicated pregnancy is possible if the age of the pregnant geminimen 26 years or properly selected antithrombotic therapy. Later than the time of menarche and the presence of a large number of mutations, mainly homozygous forms are markers of phenotypic manifestation of hereditary thrombophilia, starting with the first pregnancy. Conclusion. Timely diagnosis of genetic mutations and polymorphisms of thrombophilia (pre-pregnancy), pregravid proper training and appropriate management of pregnant women with the use of antiplatelet and (or) anticoagulant therapy let to get a good results by reducing the performance of reproductive losses and complications of pregnancy.
About the Authors
M. V. Khruslov
Kursk Regional Hospital
Russian Federation
PhD, doctor of the highest category
Russian Federation
PhD, doctor of the highest category
S. N. Zhabin
Kursk State Medical University
Russian Federation
PhD, Department of surgical diseases
Russian Federation
PhD, Department of surgical diseases
M. I. Boeva
Regional Perinatal Center, Kursk
Russian Federation
obstetrician-gynecologist
Russian Federation
obstetrician-gynecologist
I. V. Ivanov
Kursk State Medical University
Russian Federation
PhD, professor, head-chair of surgical diseases
Russian Federation
PhD, professor, head-chair of surgical diseases
I. V. Pashina
Kursk State Medical University
Russian Federation
PhD, Associate Professor
Russian Federation
PhD, Associate Professor
S. A. Avagova
Kursk State Medical University
Russian Federation
student of 6th year medical faculty
Russian Federation
student of 6th year medical faculty
References
1. Arutyunyan A.V., Zainulina M.S., Kornyushina E.A., Pustygina A.V., Mirashvili M.I. Zhurnal akusherstva i zhenskikh boleznei. 2010; LIX (4): 90-98. In Russian.
2. Bitsadze V.O, Makatsariya A.D., Khizroeva D.Kh. i dr. Prakticheskaya meditsina. 2012; 5: 22. In Russian.
3. Volkova A.S., Kruglova E.A., Kuz’min A.A., Sokolova T.M., Kuz’mina V.V. Meditsina i obrazovanie v Sibiri. 2014; 3: 79.
4. Degemerzanova N.K., Rakisheva Z.B. i dr. Genetika. 2014; 3-4 (20-21): 60-62. In Russian.
5. Instruktsiya po primeneniyu Kurantila. http://www.rosmed.info/reestrls/info.php?id=17464&action=info. In Russian.
6. Kornyushina E.A., Zainulina M.S. Zhurnal akusherstva i zhenskikh boleznei. 2008; LVII (4): 89-95. In Russian.
7. Marinkin I.O., Belousova T.V., Plyushkin V.A. Byulleten’ Sibirskogo otdeleniya Rossiiskoi akademii meditsinskikh nauk. 2011; 31(4): 43-49. In Russian.
8. Mubinova S.V., Mikhailova I.V. Tol’yattinskii meditsinskii konsilium. 2011; 1-2: 112-114. In Russian.
9. Rapil'bekova G.K., Mamedalieva N.M. Zhurnal akusherstva i zhenskikh boleznei. 2006; LV: 3: 31-34. In Russian.
10. Sidel'nikova V.M. Rus. med. zhurnal. 2008; V 16 (6): 1-6.
11. Stepanova A.A., Drobinskaya A.N., Pasman N.M., Sturov V.G. Vestnik Novosibirskogo gosudarstvennogo universiteta. Seriya: Biologiya, klinicheskaya meditsina. 2009; 7 (2): 34-43. In Russian.
12. Khruslov M.V., Boeva M.I., Zhabin S.N., Ukhanova I.Yu., Avagova S.A. Tromboz, gemostaz I reologiya. 2014; 3 (59): 35-38. In Russian.
13.
14.
Review
For citations:
Khruslov M.V., Zhabin S.N., Boeva M.I., Ivanov I.V., Pashina I.V., Avagova S.A. The study of normal pregnancy in women with hereditary thrombophilia. Obstetrics, Gynecology and Reproduction. 2015;9(2):6-12. (In Russ.) https://doi.org/10.17749/2070-4968.2015.9.2.006-012
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