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Cerebral circulation disorders in women using combined oral contraceptives

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The study is aimed at using combined oral contraceptives (COCs) and subsequent risk of developing cerebral circulation disorders (CCD), which is posed at the fine border between gynecology, hemostasiology and neurology. We discuss risk factors for thrombotic complications occurring upon COCs administration, pathogenetic mechanisms behind CCD, a COCs impact on hemostasis system, and their relation to risk of developing diverse stroke types. Inherited and acquired thrombophilia are discussed as one of the most important factors determining elevated CCD risk related to COCs use. We provide a detailed description of most thrombogenic genetic polymorphisms such as mutated Factor V Leiden gene, prothrombin G20210А gene etc., their role in stroke development, including conditions for COCs use. Special emphasis is made on insights into inherited and acquired АDАMTS-13 deficiency as well as antiphospholipid syndrome as factors contributing to stroke in females receiving hormonal contraceptives.

About the Authors

M. D. Andreeva
Kuban State Medical University, Health Ministry of Russian Federation
Russian Federation

Margarita D. Andreeva – MD, Dr Sci Med, Professor, Associate Professor, Department of Obstetrics, Gynecology and Perinatology

Scopus Author ID: 57200068605

4 Mitrofana Sedina Str., Krasnodar 350063

M. G. Novosartyan
Kuban State Medical University, Health Ministry of Russian Federation
Russian Federation

Margarita G. Novosartyan – MD, Postgraduate Student, Department of Obstetrics, Gynecology and Perinatology

4 Mitrofana Sedina Str., Krasnodar 350063

N. V. Samburova
Sechenov University
Russian Federation

Natalia V. Samburova – MD, PhD, Associate Professor, Department of Pathophysiology, Institute of Clinical Medicine

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991

I. V. Khamani
Sechenov University
Russian Federation

Inessa V. Khamani – MD, PhD, Associate Professor, Department of Obstetrics and Gynecology, Filatov Clinical Institute of Children’s Health

2 bldg. 4, Bolshaya Pirogovskaya Str., Moscow 119991


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For citation:

Andreeva M.D., Novosartyan M.G., Samburova N.V., Khamani I.V. Cerebral circulation disorders in women using combined oral contraceptives. Obstetrics, Gynecology and Reproduction. 2021;15(2):173-181. (In Russ.)

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ISSN 2313-7347 (Print)
ISSN 2500-3194 (Online)