Clinical significance of expression of the marker of adaptation to hypoxia HIF-1α in pregnant women with initial forms of venous disease
Abstract
Aim: to study the activity of the HIF-1á (hypoxia-inducible factor-1á) hypoxia marker in pregnant women with phlebopathy and its relationship with placenta morphological changes and perinatal complications.
Materials and Methods. 70 women with phlebopathy were dynamically examined during pregnancy. The main group consisted of 30 patients with newborns showing signs of hypoxia; the control group consisted of 40 women with healthy children. All women underwent ultrasound examinations of the lower extremity veins and pelvis by assessing vascular patency, state of venous valves, and intensity of platelet sludge. Expression of the HIF-1á transcription factor at gestational age of 18–20 and 36 weeks was performed by using real-time polymerase chain reaction.
Results. Altered functional state of the veins was found in all pregnant women from the main group, which was accompanied by formation of varying degree platelet sludge in the area of the venous valves in the majority of women, as well as signs of endothelial dysfunction and venous hypoxia highlighted with HIF1-á gene expression upregulated by 2.18-fold. No changes in such parameters were observed in control group.
Conclusion. The transcription factor HIF1-á can be considered as a marker of unfavorable perinatal outcomes in pregnant women with signs of phlebopathy.
About the Authors
E. Iu. Iupatov
Kazan State Medical Academy – Branch of Russian Medical Academy of Continuing Professional Education, Health Ministry of Russian Federation; Kazan (Volga Region) Federal University
Russian Federation
Russian Federation
Evgenii Iu. Iupatov – MD, PhD, Associate Professor, Head of the Department of Obstetrics and Gynecology, Kazan State Medical Academy; Associate Professor, Department of Surgery and Postgraduate Education, Institute of Fundamental Medicine and Biology, Kazan (Volga Region) Federal University; Scopus Author ID: 57201192778
11 Mushtari Str., Kazan 420012
18 Kremlevskaya Str., Kazan 420008
L. I. Maltseva
Kazan State Medical Academy – Branch of Russian Medical Academy of Continuing Professional Education, Health Ministry of Russian Federation
Russian Federation
Russian Federation
Larisa I. Maltseva – MD, Dr Sci Med, Professor, Department of Obstetrics and Gynecology
11 Mushtari Str., Kazan 420012
T. P. Zefirova
Kazan State Medical Academy – Branch of Russian Medical Academy of Continuing Professional Education, Health Ministry of Russian Federation
Russian Federation
Russian Federation
Tatiana P. Zefirova – MD, Dr Sci Med, Professor, Department of Obstetrics and Gynecology
11 Mushtari Str., Kazan 420012
R. S. Zamaleeva
Kazan State Medical Academy – Branch of Russian Medical Academy of Continuing Professional Education, Health Ministry of Russian Federation
Russian Federation
Russian Federation
Roza S. Zamaleeva – MD, Dr Sci Med, Professor, Department of Obstetrics and Gynecology
11 Mushtari Str., Kazan 420012
I. M. Ignatiev
Kazan State Medical University, Health Ministry of Russian Federation
Russian Federation
Russian Federation
Igor М. Ignatiev – MD, Dr Sci Med, Corresponding Member of the Academy of Sciences of the Republic of Tatarstan, Professor, Department of Cardiovascular and Endovascular Surgery
49 Butlerova Str., Kazan 420012
O. A. Kravtsova
Kazan (Volga Region) Federal University
Russian Federation
Russian Federation
Olga A. Kravtsova – MD, PhD, Associate Professor, Department of Biochemistry and Biotechnology, Institute of Fundamental Medicine and Biology
18 Kremlevskaya Str., Kazan 420008
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Review
For citations:
Iupatov E.I., Maltseva L.I., Zefirova T.P., Zamaleeva R.S., Ignatiev I.M., Kravtsova O.A. Clinical significance of expression of the marker of adaptation to hypoxia HIF-1α in pregnant women with initial forms of venous disease. Obstetrics, Gynecology and Reproduction. 2021;15(3):276-286. (In Russ.) https://doi.org/10.17749/2313-7347/ob.gyn.rep.2021.208
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