Preview

Obstetrics, Gynecology and Reproduction

Advanced search

Phytoestrogens in treatment of climacteric syndrome as an alternative to menopausal hormone therapy

https://doi.org/10.17749/2313-7347/ob.gyn.rep.2020.186

Full Text:

Abstract

Here we review Russia-wide and international publications released over the last 5 years dedicated to phytoestrogens used in treatment of climacteric syndrome. Effects of isoflavones as the most examined agents are discussed acting on vasomotor, cognitive, psychological, urogenital and sexual symptoms as well as on the cardiovascular system, bones, and metabolic age-related changes. Despite obtaining controversial data resulting from the analysis, it may be concluded phytoestrogens hold promise as an alternative to menopausal hormone therapy. It is reasonable to conduct further extensive studies to evaluate efficacy and safety of using plant-derived compounds in postmenopausal women.

About the Authors

M. I. Mazitova
Kazan State Medical Academy – Branch of Russian Medical Academy of Continuing Professional Education, Health Ministry of Russian Federation
Russian Federation

Madina I. Mazitova – MD, Dr Sci Med, Professor, Professor, Department of Obstetrics and Gynecology

36, Butlerova Str., Kazan 420015



I. R. Talipova
Medical and Diagnostic Center "Razumed" LLC
Russian Federation

Ilseiar R.Talipova – MD, Obstetrician-Gynecologist

53a Yulius Fuchik Str., Kazan 420138



R. R. Mardieva
Kazan State Medical Academy – Branch of Russian Medical Academy of Continuing Professional Education, Health Ministry of Russian Federation; City Clinical Hospital № 7
Russian Federation

Reseda R. Mardieva – MD, Assistant, Department of Obstetrics and Gynecology;

36, Butlerova Str., Kazan 420015;

54 Marshal Chuikov Str., Kazan 420103



References

1. Russia in numerals. 2020. Short statistics digest. [Rossiya v cifrah. 2020. Kratkij statisticheskij sbornik]. Moskva: Rosstat, 2020. 550 s. (In Russ.). Available at: https://rosstat.gov.ru/storage/mediabank/GOyirKPV/Rus_2020.pdf. [Accessed: 05.11.2020].

2. Prilepskaya V.N Climacteric syndrome: novel modalities for menopausal therapy. [Klimaktericheskij sindrom: innovacii v menopauzal'noj terapii]. RMZh. Mat' i ditya. 2017;25(2):105–8. (In Russ.).

3. Radzinsky V.E., Ordiyants I.M. Treatment of climacteric disorders in menopause. [Lechenie klimaktericheskih rasstrojstv v menopause]. RMZh. 2018;26(5–1):37–40. (In Russ.).

4. Franco O.H., Chowdhury R., Troup J. et al. Use of plant-based therapies and menopausal symptoms: a systematic review and meta-analysis. JAMA. 2016;315(23):2554–63. https://doi.org/10.1001/jama.2016.8012.

5. Kovalyova L.A. Additional options for climacteric syndrome treatment. [Dopolnitel'nye vozmozhnosti terapii klimaktericheskogo sindroma]. Medicinskij alfavit. 2017;3(23):42–5. (In Russ.).

6. Zaydieva Ya.Z. Alternative therapy of menopausal disorders in women of climacterical age (literature review). [Al'ternativnaya terapiya menopauzal'nyh rasstrojstv u zhenshchin v klimakterii]. RMZh. Mat' i ditya. 2017;(12):873–8. (In Russ.).

7. Kuznetsova I.V. Hormones or non-hormonal agents in menopause? [Gormony ili negormonal'nye sredstva v klimakterii?]. Medicinskij alfavit. 2016;2(17):6–12. (In Russ.).

8. Adlercreutz H., Hamalainen E., Gorbach S., Goldin B. Dietary phytoestrogens and the menopause in Japan. Lancet.1992;339(8803):1233. https://doi.org/10.1016/0140-6736(92)91174-7.

9. Dikke G.B. Menopausal syndrome: associated symptoms and their mechanisms are the keys to comprehend alternative pathogenic treatment. [Menopauzal'nyj sindrom: simptomy i mekhanizm ih vozniknoveniya – klyuch k ponimaniyu al'ternativ patogeneticheskogo lecheniya]. RMZh. Mat' i ditya. 2019;(2):57–64. https://doi.org/10.32364/2618-8430-2019-2-1-57-64. (In Russ.).

10. Lock M. Menopause: lessons from anthropology. Psychosom Med. 1998;60(4):410–9. https://doi.org/10.1097/00006842-199807000-00005.

11. Avis N.E., Kaufert P.A., Lock M. et al. The evolution of menopausal symptoms. In: Balliere's Clinical Endocrinology and Metabolism. Ed. H. Burger. 1993;7(1):17–32. London: Harcourt, Brace Jovanovich Publishers, 1993. https://doi.org/10.1016/S0950-351X(05)80268-X.

12. Morton M.S., Arisaka O., Miyake N. et al. Phytoestrogen concentrations in serum from Japanese men and women over forty years of age. J Nutr. 2002;132(10):3168–71. https://doi.org/10.1093/jn/131.10.3168.

13. Parkin D.M. Global cancer statistics in the year 2000. Lancet Oncol. 2001;2(9):533–43. https://doi.org/10.1016/S1470-2045(01)00486-7.

14. Ajiki W., Yamamoto S. Cancer statistics digest. Breast cancer incidence for females in Japan. Jpn J Clin Oncol. 1999;29(4):238a.

15. Bray F., McCarron P., Parkin D.M. The changing global patterns of female breast cancer incidence and mortality. Breast Cancer Res. 2004;6(6):229–39. https://doi.org/10.1186/bcr932.

16. Estrada-Camarena E., López-Rubalcava C., Valdés-Sustaita B. et al. Use of phytoestrogens for the treatment of psychiatric symptoms associated with menopause transition. In: A Multidisciplinary Look at Menopause. Eds. J.F. Rodriguez-Landa, J. Cueto-Escobedo. InTech, 2017. 81–109. https://doi.org/10.5772/intechopen.69541.

17. Kolátorová L., Lapčík O., Stárka L. Phytoestrogens and the intestinal microbiome. Physiol Res. 2018;67(Suppl 3):S401–S408. https://doi.org/ 10.33549/physiolres.934022.

18. Keshavarz Z., Golezar S., Hajifoghaha M., Alizadeh S. The effect of phytoestrogens on menopause symptoms: A systematic review. J Isfahan Med Sch. 2018;36(477):446–59. https://doi.org/10.22122/jims.v36i477.9503.

19. Křížová L., Dadáková K., Kašparovská J., Kašparovský T. Isoflavones. Molecules. 2019;24(6):1076. https://doi.org/10.3390/molecules24061076.

20. Frankenfeld C.L. Cardiometabolic risk and gut microbial phytoestrogen metabolite phenotypes. Mol Nutr Food Res. 2017;61(1). https://doi.org/10.1002/mnfr.201500900.

21. Schmidt M., Arjomand-Wolkart K., Birkhauser M.H. et al. Consensus: Soy isoflavones as a first-line approach to the treatment of menopausal vasomotor complaints. Gynecol Endocrinol. 2016;32(6):427–30. https://doi.org/10.3109/09513590.2016.1152240.

22. Pons D.G., Vilanova-Llompart J., Gaya-Bover A. et al. The phytoestrogen genistein affects inflammatory-related genes expression depending on the ERα/ERβ ratio in breast cancer cells. Int J Food Sci Nutr. 2019;70(8):941–9. https://doi.org/10.1080/09637486.2019.1597025.

23. Bansal R., Aggarwal N. Menopausal hot flashes: A concise review. J Midlife Health. 2019;10(1):6–13. https://doi.org/10.4103/jmh.JMH_7_19.

24. McGarry K., Geary M., Gopinath V. Beyond estrogen: treatment options for hot flashes. Clin Ther. 2018;40(10):1778–86. https://doi.org/10.1016/j.clinthera.2018.08.010.

25. Dreval A.V. Menopause (lecture). [Menopauza (lekciya)]. RMZh. 2018;1(I):3–7. (In Russ.).

26. Smith R.L., Gallicchio L., Miller S.R. et al. Risk factors for extended duration and timing of peak severity of hot flashes. PLoS One. 2016;11(5):e0155079. https://doi.org/10.1371/journal.pone.0155079.

27. Daily J.W., Ko B.S., Ryuk J. et al. Equol decreases hot flashes in postmenopausal women: a systematic review and meta-analysis of randomized clinical trials. J Med Food. 2019;22(2):127–39. https://doi.org/10.1089/jmf.2018.4265.

28. Hemati N., Asis M., Moradi S. et al. Effects of genistein on blood pressure: A systematic review and meta-analysis. Food Res Int. 2020;128:108764. https://doi.org/10.1016/j.foodres.2019.108764.

29. Palma F., Fontanesi F., Neri I. et al. Blood pressure and cardiovascular risk factors in women treated for climacteric symptoms with acupuncture, phytoestrogens, or hormones. Menopause. 2020 Aug 17. https://doi.org/10.1097/GME.0000000000001626. [Online ahead of print].

30. Lu L.W., Chen N.W., Nayeem F. et al. Soy isoflavones interact with calcium and contribute to blood pressure homeostasis in women: a randomized, double-blind, placebo controlled trial. Eur J Nutr. 2020;59(6):2369–81. https://doi.org/10.1007/s00394-019-02085-3.

31. Myers S.P., Vigar V. Effects of a standardised extract of Trifolium pratense (Promensil) at a dosage of 80 mg in the treatment of menopausal hot flushes: A systematic review and meta-analysis. Phytomedicine. 2017;24:141–7. https://doi.org/10.1016/j.phymed.2016.12.003.

32. Davinelli S., Scapagnini G., Marzatico F. et al. Influence of equol and resveratrol supplementation on health-related quality of life in menopausal women: A randomized, placebo-controlled study. Maturitas. 2017;96:77–83. https://doi.org/10.1016/j.maturitas.2016.11.016.

33. Cui C., Birru R.L., Snitz B.E. et al. Effects of soy isoflavones on cognitive function: a systematic review and meta-analysis of randomized controlled trials. Nutr Rev. 2020;78(2):134–44. https://doi.org/10.1093/nutrit/nuz050.

34. Najafi M.N., Ghazanfarpour M. Effect of phytoestrogens on sexual function in menopausal women: a systematic review and metaanalysis. Climacteric. 2018;21(5):437–45. https://doi.org/10.1080/13697137.2018.1472566.

35. Dizavandi F.R., Ghazanfarpour M., Roozbeh N. et al. An overview of the phytoestrogen effect on vaginal health and dyspareunia in peri- and post-menopausal women. Post Reprod Health. 2019;25(1):11–20. https://doi.org/10.1177/2053369118823365.

36. Caruso S., Cianci S., Fava V et al. Vaginal health of postmenopausal women on nutraceutical containing equol. Menopause. 2018;25(4):430–5. https://doi.org/10.1097/GME.0000000000001061.

37. Luís A., Domingues F., Pereira L. Effects of red clover on perimenopausal and postmenopausal women’s blood lipid profile: A meta-analysis. Climacteric. 2018;21(5):446–53. https://doi.org/10.1080/13697137.2018.1501673.

38. Glisic M., Kastrati N., Gonzalez-Jaramillo V. et al. Associations between phytoestrogens, glucose homeostasis, and risk of diabetes in women: A systematic review and meta-analysis. Adv Nutr. 2018;9(6):726–40. https://doi.org/10.1093/advances/nmy048.

39. Glisic M., Kastrati N., Musa J. et al. Phytoestrogen supplementation and body composition in postmenopausal women: A systematic review and meta-analysis of randomized controlled trials. Maturitas. 2018;115:74–83. https://doi.org/10.1016/j.maturitas.2018.06.012.

40. De Gregorio C., Marini H., Alibrandi A. et al. Genistein supplementation and cardiac function in postmenopausal women with metabolic syndrome: results from a pilot strain-echo study. Nutrients. 2017;9(6):584. https://doi.org/10.3390/nu9060584.

41. Kuznetsova I.V., Voichenko N.A., Kirillova M.Yu. Quality of life and cardiovascular risk in women during menopausal transition and postmenopause. [Kachestvo zhizni i kardiovaskulyarnyj risk u zhenshchin v periodah menopauzal'nogo perekhoda i postmenopauzy]. Medicinskij alfavit. 2020;(4):39–45. https://doi.org/10.33667/2078-5631-2020-4-39-35. (In Russ.).

42. Myasoedova V.A., Kirichenko T.V., Melnichenko A.A. et al. Antiatherosclerotic effects of a phytoestrogen-rich herbal preparation in postmenopausal women. Int J Mol Sci. 2016;17(8):1318. https://doi.org/10.3390/ijms17081318.

43. Wang T., Liu Q., Tjhioe W. et al. Therapeutic potential and outlook of alternative medicine for osteoporosis. Curr Drug Targets. 2017;18(9):1051–68. https://doi.org/10.2174/1389450118666170321105425.

44. Lambert M.N.T, Jeppesen P.B. Isoflavones and bone health in perimenopausal and postmenopausal women. Curr Opin Clin Nutr Metab Care. 2018;21(6):475–80. https://doi.org/10.1097/MCO.0000000000000513.

45. Abdi F., Alimoradi Z., Haqi P., Mahdizad F. Effects of phytoestrogens on bone mineral density during the menopause transition: a systematic review of randomized, controlled trials. Climacteric. 2016;19(6):535–45. https://doi.org/10.1080/13697137.2016.1238451.

46. 46. Jaiswal N., Akhtar J., Singh S.P. et al. An overview on genistein and its various formulations. Drug Res (Stuttg). 2019;69(6):305-313. https://doi.org/10.1055/a-0797-3657.

47. Filipović B., Šošić-Jurjević. B., Ajdžanović V. et al. The phytoestrogen genistein prevents trabecular bone loss and affects thyroid follicular cells in a male rat model of osteoporosis. J Anat. 2018;233(2):204–12. https://doi.org/10.1111/joa.12828.

48. Liu T., Li N., Yan Y.Q. et al. Recent advances in the anti-aging effects of phytoestrogens on collagen, water content, and oxidative stress. Phytother Res. 2020;34(3):435–47. https://doi.org/10.1002/ptr.6538.

49. Lephart E.D. Resveratrol, 4′ acetoxy resveratrol, R-equol, racemic equol or S-equol as cosmeceuticals to improve dermal health. Int J Mol Sci. 2017;18(6):1193. https://doi.org/10.3390/ijms18061193.

50. Yao R., Tanaka M., Misawa E. et al. Daily ingestion of aloe vera gel powder containing aloe sterols prevents skin photoaging in OVX hairless mice. J Food Sci. 2016;81(11):H2849–H2857. https://doi.org/10.1111/1750-3841.13527.

51. Savoia P., Raina G., Camillo L. et al. Anti-oxidative effects of 17 β-estradiol and genistein in human skin fibroblasts and keratinocytes. J Dermatol Sci. 2018;92(1):62–77. https://doi.org/10.1016/j.jdermsci.2018.07.007.

52. Štulíková K., Karabín M., Nešpor J., Dostálek P. Therapeutic perspectives of 8-prenylnaringenin, a potent phytoestrogen from hops. Molecules. 2018;23(3):660. https://doi.org/10.3390/molecules23030660.

53. Dietz B.M., Hajirahimkhan A., Dunlap T.L., Bolton J.L. Botanicals and their bioactive phytochemicals for women's health. Pharmacol Rev. 2016;68(4):1026–73. https://doi.org/10.1124/pr.115.010843.

54. Gaya P., Medina M., Sánchez-Jiménez A., Landete J.M. Phytoestrogen metabolism by adult human gut microbiota. Molecules. 2016;21(8):1034. https://doi.org/10.3390/molecules21081034.

55. Chang V.C., Cotterchio M., Boucher B.A. et al. Effect of dietary flaxseed intake on circulating sex hormone levels among postmenopausal women: A randomized controlled intervention trial. Nutr Cancer. 2019;71(3):385–98. https://doi.org/10.1080/01635581.2018.1516789.

56. Evans H.M., Howe P.R., Wong R.H. Effects of resveratrol on cognitive performance, mood and cerebrovascular function in post-menopausal women; a 14-week randomized placebo-controlled intervention trial. Nutrients. 2017;9(1):27. https://doi.org/10.3390/nu9010027.

57. Wong R.H., Thaung Zaw J.J., Xian C.J., Howe P.R. Regular supplementation with resveratrol improves bone mineral density in postmenopausal women: a randomized, placebo-controlled trial. J Bone Miner Res. 21 June 2020. https://doi.org/10.1002/jbmr.4115.

58. Wong R.H.X., Evans H.M., Howe P.R.C. Resveratrol supplementation reduces pain experience by postmenopausal women. Menopause. 2017;24(8):916–22. https://doi.org/10.1097/GME.0000000000000861.


For citation:


Mazitova M.I., Talipova I.R., Mardieva R.R. Phytoestrogens in treatment of climacteric syndrome as an alternative to menopausal hormone therapy. Obstetrics, Gynecology and Reproduction. 2020;14(6):685-693. (In Russ.) https://doi.org/10.17749/2313-7347/ob.gyn.rep.2020.186

Views: 205


ISSN 2313-7347 (Print)
ISSN 2500-3194 (Online)