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Features of the second half of pregnancy in women with labor abnormalities

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Aim: conduct a systematic analysis of pregnancy development, investigate clinical and laboratory data affecting development of labor abnormalities in women residing in the Belgorod region.
Materials and Methods. From 2014 to 2018, 484 women were examined and divided into 2 groups: main group consisted of those who had childbirth complicated with labor abnormalities (n = 344), whereas control group consisted of women lacking complications during delivery (n = 140). The following methods were used in the study: questionnaires, general clinical methods, biochemical blood tests in pregnant and postpartum women, populational statistics as well as methods of standard and multivariate statistics.
Results. In the second half of pregnancy in women with labor abnormalities revealed higher rate of moderate preeclampsia (34.30 ± 2.56 % vs. 10.71 ± 2.61%; p < 0.05), polyhydramnios (11.34 ± 1.71 % vs. 5.71 ± 1.96 %; p < 0.05), chronic intrauterine hypoxia (29.6 ± 2.46 % vs. 12.86 ± 2.83 %; p < 0.05), chronic utero-placental insufficiency (60.47 ± 2.64 % vs. 20.00 ± 3.38 %; p < 0.05), sexually transmitted infections (3.78 ± 1.03 % vs. 0.71 ± 0.71 %; p < 0.05), acute respiratory viral infection (8.72 ± 1.52 % vs. 3.57 ± 1.57 %; p < 0.05) as well as a combination of several types of pathology (8.72 ± 1.52 % vs. 13.57 ± 2.89 %; p < 0.05). Laboratory parameters in women with labor abnormalities compared with control antepartum group were noted to have significantly decreased count of red blood cells (3.89 ± 0.38×1012/L vs. 3.99 ± 0.40×1012/L; p = 0.006), eosinophils (0.95 ± 0.69×109/L vs. 1.20 ± 0.67×109/L; p = 0.026) and platelets (226.29 ± 62.71×109/L vs. 245.44 ± 60.32×109/L; p = 0.0003). Blood biochemical parameters in women with labor abnormalities vs. control group were featured with significantly decreased level of bilirubin (6.76 ± 3.16 μmol/L vs. 9.88 ± 3.60 μmol/L; p < 0.05) and alanine aminotransferase (13.94 ± 10.08 U/L vs. 19.41 ± 14.40 U/L; p = 0.004). Analyzing coagulation parameters in the main group showed significantly reduced fibrinogen level (4.30 ± 1.00 g/L) compared with control group (4.71 ± 1.14 g/L; p < 0.05) as well as elevated international normalized ratio (1.07 ± 0.11 vs. 1.03 ± 0.10; p = 0.001).
Conclusion. Our study data found that pregnant women with labor abnormalities had altered clinical and laboratory parameters observed as early as in the second half of gestation, which may be used to calculate an individual risk of such labor complication.

About the Authors

U. G. Shokirova
Belgorod State National Research University
Russian Federation

Umeda G. Shokirova – MD, Postgraduate Student, Department of Obstetrics and Gynecology

85 Pobedy Str., Belgorod 308007


S. P. Pakhomov
Belgorod State National Research University
Russian Federation

Sergey P. Pakhomov – MD, Dr Sci Med, Professor, Department of Obstetrics and Gynecology

85 Pobedy Str., Belgorod 308007

A. S. Ustyuzhina
Belgorod State National Research University; Belgorod Regional Clinical Hospital of St. Joasaph
Russian Federation

Alexandra S. Ustyuzhina – MD, Postgraduate Student, Department of Obstetrics and Gynecology

85 Pobedy Str., Belgorod 308007;


8/9 Nekrasov Str., Belgorod, 308007

A. V. Matrosova
Belgorod State National Research University
Russian Federation

Alina V. Matrosova – MD, Postgraduate Student, Department of Obstetrics and Gynecology

85 Pobedy Str., Belgorod 308007


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For citation:

Shokirova U.G., Pakhomov S.P., Ustyuzhina A.S., Matrosova A.V. Features of the second half of pregnancy in women with labor abnormalities. Obstetrics, Gynecology and Reproduction. 2020;14(6):659-665. (In Russ.)

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