Obstetrics, Gynecology and Reproduction

Advanced search


Full Text:


We studied the indexes of antioxidative defence – the concentration of active form of enzymes ceruloplasmin (CP) and transferin (TF) and NO-capacity of the protein of blood in 60 women with external endometriosis by method spectroscopy. The concentration of active form of ceruloplasmin was increased and the concentration of transferin was decreased in women with external endometriosis; the index CP/TF was increased. The NO-connective capacity of the
blood was significant increased in this group of women comparing with their relatives and the control (healthy women) group. These changes are the result of the breach of balance in the system oxidant\antioxidant and the development of oxidative stress in this group of women.

About the Authors

L. V. Adamyan
Moscow State University of Medicine and Dentistry
Russian Federation

O. N. Loginova
Moscow State University of Medicine and Dentistry
Russian Federation

M. M. Sonova
Moscow State University of Medicine and Dentistry
Russian Federation

K. N. Arslanyan
Moscow State University of Medicine and Dentistry
Russian Federation


1. Adamyan L.V., Kulakov I.I., Andreeva E.N.Endometriosis: A Guide for Physicians. Ed. 2nd, revised. and ext. [Endometriozy: Rukovodstvo dlya vrachei. Izd. 2-e, pererab. i dop.]. Moscow. 2006; 416 s.

2. Kutsenko N.I. Gudkov G.V., Tomina O.V. Rossiiskii vestnik akushera-ginekologa. 2003; 3 (5): 13-16.

3. Podoprigorova V.G. Rol’ svobodnoradikal’nogo okisleniya lipidov i antioksidantnykh sistem v patogeneze i sanogeneze yazvennoi bolezni zheludka i dvenadtsatiperstnoi kishki, vozmozhnosti korrektsii antioksidantami. Doct, Diss. (The role of free radical oxidation of lipids and antioxidant systems in the pathogenesis and sanogenesis gastric ulcer and duodenal ulcers, the possibility of correction by antioxidants).Dr. diss. Moscow. 1998; 40 s.

4. Agarwal A., Alamaneni S. Oxidants and antioxidants in human fertility. Middle East Fertility Journal. 2004; 9: 187-197.

5. Agarwal A., Gupta S., K Sharma R. Role of oxidative stress in female reproduction. Reprod Biol Endocrinol. 2005; 3: 28.

6. Agarwal A., Gupta S., Krajcir N. Role of oxidative stress in endometriosis. Reproductive BioMedicine Online. July 2006; 13 (1): 126-134.

7. Bedaiwy M.A., Falcone T. Peritoneal fluid environment in endometriosis. Clinicopathological implications. Minerva Ginecologica. 2003; 55: 333-345.

8. Cao X., Yang D., Song M. et al. The presence of endometrial cells in the peritoneal cavity enhances monocyte recruitment and induces infl ammatory cytokines in mice: implications for endometriosis. Fertility and Sterility. 2004; 82 (3): 999-1007.

9. Dong M., Shi Y., Cheng Q. et al. Increased nitric oxide in peritoneal fluid from women with idiopathic infertility and endometriosis. Journal of Reproductive Medicine. 2001; 46: 887-891.

10. Kamada Y., Nakatsuka M., Asagiri K. et al. GnRH agonistsuppressed expression of nitric oxide synthases and generation of peroxynitrite in adenomyosis. Human Reproduction. 2000; 15: 2512-2519.

11. Khorram O., Lessey B.A. Alterations in expression of endometrial endothelial nitric oxide synthase and αvβ3 integrin in women with endometriosis. Fertility and Sterility. 2002; 78, 860-864.

12. Murphy A.A., Palinski W., Rankin S. et al. Evidence for oxidatively modified lipid-protein complexes in endometrium and endometriosis. Fertility and Sterility. 1998; 69: 1092-1094.

13. Nuojua-Huttunen S., Tomas C., Bloigu R. et al. Intrauterine insemination treatment in subfertility: an analysis of factors affecting outcome. Human Reproduction. 1999; 14: 698-703.

14. Omland A.K., Tanbo T., Dale P.O. et al. Artificial insemination by husband in unexplained infertility compared with infertility associated with peritoneal endometriosis. Human Reproduction. 1998; 13: 2602-2605.

15. Sikka S.C. Role of oxidative stress and antioxidants in andrology and assisted reproductive technology. Journal of Andrology. 2004; 25: 5-18.

16. Van Langendonckt A., Casanas-Roux F., Donnez J. Oxidative stress and peritoneal endometriosis. Fertility and Sterility. 2002; 77: 861-870.

17. Wu M.Y., Chao K.H., Yang J.H. et al. Nitric oxide synthesis is increased in the endometrial tissue of women with endometriosis. Human Reproduction. 2003; 18: 2668-2671.

18. Men'shchikova E.B., Lankin V.Z. i dr. Okislitel'nyi stress. Prooksidanty i antioksidanty. M. 2006; 84-111, 414-420.




For citations:

Adamyan L.V., Loginova O.N., Sonova M.M., Arslanyan K.N. THE ANTIOXIDATIVE DEFENCE IN WOMEN WITH EXTERNAL ENDOMETRIOSIS. Obstetrics, Gynecology and Reproduction. 2014;8(3):18-21. (In Russ.)

Views: 306

ISSN 2313-7347 (Print)
ISSN 2500-3194 (Online)