CLINICAL AND IMMUNOLOGICAL COURSE OF GESTATION DURING PREGNANCY INDUCED HYPERTENSION
Abstract
The aim of this research was studies character of clinical course of gestation and immunological markers in pregnant women with gestational hypertension and pre-eclampsia. In150 pregnant women with gestational hypertension and pre-eclampsia (basic group I) and 50 healthy pregnant women at the same gestational period (control group) was studies clinical course of gestation and plazma levels of twelve natural autoantibodies. The levels of autoantibodies throughout pregnancy were analyzed with an ELISA assay. First gestational trimester with hypertensive disorders accompanied with different complications in 62% of cases ,every second woman (50%) has complications during second trimester while pregnancy-induced hypertension and third trimester at pregnancy-induced hypertension has complications in 56,7% of cases ,and every third woman has fetoplacental insufficiency. The levels of В-2QP, S-100 and ANCA autoantibodies increase during pregnancy in women with gestational hypertension and pre-eclampsia. Quantification of the value of the level of autoantibodies directly depends on the severity of hypertensive disorders.
About the Author
N. A. Shakhbazova
Scientific-Research Institute of Obstetrics and Gynecology (Baku, Azerbaijan)
Azerbaijan
Azerbaijan
References
1. Makarov O.V., Tkacheva O.N., Volkova E.V. Pre-eclampsia and chronic hypertension. Clinical aspects [Preeklampsiya i khronicheskaya arterial’naya gipertenziya. Klinicheskie aspekty]. Moscow. 2010; 136 s.
2. Poletaev A.B., Kuz'menko L.G. Immuno-and molecular diagnostics [Immunomolekulyarnaya diagnostika]. Moscow. 2006; 36 s.
3. Poletaev A.B. Immunophysiology and immunopathology [Immunofiziologiya i immunopatologiya]. Moscow. 2008; 198 s.
4. Poletaev A.B., Morozov S.G. Methods Elip test in assessing the status of reproductive health of women of childbearing age [Metody ELIPTestov v otsenke sostoyaniya reproduktivnogo zdorov’ya zhenshchin fertil’nogo vozrasta]. Moscow. 2001; 16 s.
5. Sidorova I.S., Unanyan A.L., Nikitina N.A., Rzaeva A.A., Kinyakin V.V. Akusherstvo, ginekologiya i reproduktsiya. 2012; 4: 29-32.
6. Anderssohn M., Maas L.M., Diemert A. Severely decreased activity of placental dimethylarginine dimethylaminohydrolase in pre-eclampsia. Eur. J. Obstet. Gynecol. Reprod. Biol. 2012; 161 (2): 152-6.
7. Abrahams V.M. Mechanisms of antiphospholipid antibody-associated pregnancy complications. Thromb Res. 2009 Nov; 124 (5): 521-5.
8. El-Baradie S.M., Mahmoud M., Makhlouf H.H. Elevated serum levels of interleukin-15, interleukin-16, and human chorionic gonadotropin in women with preeclampsia. J Obstet Gynaecol Can. 2009 Feb; 31 (2): 142-8.
9. Facchinetti F., Marozio L., Frusca T., Grandone E., Venturini P., Tiscia G.L., Zatti S., Benedetto C. Maternal thrombophilia and the risk of recurrence of preeclampsia. Am J Obstet Gynecol. 2009 Jan; 200 (1): 46.e1-5.
10. Gong Y.H., Jia J., Lü D.H. Outcome and risk factors of early onset severe preeclampsia. Chin Med J (Engl). 2012 Jul; 125 (14): 2623-7.
11. Heikura U, Hartikainen A.L., Nordström T. Maternal hypertensive disorders during pregnancy and mild cognitive limitations in the offspring. Paediatr Perinat Epidemiol. 2013 Mar; 27 (2): 188-98.
12. Hutcheon J.A., Lisonkova S., Joseph K.S. Epidemiology of pre-eclampsia and the other hypertensive disorders of pregnancy. Best. Pract. Res. Clin. Obstet. Gynaecol. 2011 Aug; 25 (4): 391-403.
13. Hypertension in Pregnancy: The Management of Hypertensive Disorders During Pregnancy. NICE Clinical Guidelines. London. 2010; 107.
14. Kurabayashi T., Mizunuma H., Kubota T. Pregnancy-induced hypertension is associated with maternal history and a risk of cardiovascular disease in later life: A Japanese cross-sectional study. Maturitas. 2013 May 7; pii: S0378-5122(13)00106-0.
15. Lamarca B. Endothelial dysfunction. An important mediator in the pathophysiology of hypertension during pre-eclampsia. Minerva Ginecol. 2012; 64 (4): 309-20.
16. Lo J.O., Mission J.F., Caughey A.B. Hypertensive disease of pregnancy and maternal mortality. Curr Opin Obstet Gynecol. 2013 Apr; 25 (2): 124-32.
17. McDonald S.D., Han Z., Walsh M.W., Gerstein H.C. Kidney disease after preeclampsia: a systematic review and meta-analysis. Am. J Kidney Dis. 2010 Jun; 55 (6): 1026-1039.
18. McSharry C. Chronic kidney disease: Early CKD increases the risk of adverse outcomes in pregnancy. Nat. Rev. Nephrol. 2010 Jul; 6 (7): P. 385.
19. Pettit F.В., Brown M.A. The management of pre-eclampsia: what we think we know. Eur. J. Obstet. Gynecol. Reprod. Biol. 2012; 160 (1): 6-12.
20. Romundstad P.R., Magnussen E.B., Smith G.D. Hypertension in pregnancy and later cardiovascular risk: common antecedents? J Circulation. 2010 Aug 3; 122 (5): 478-487.
21. Shamshirsaz A.A., Paidas M., Krikun G. Preeclampsia, hypoxia, thrombosis, and inflammation. J. Pregnancy. 2012; 374047.
22. The Society of Obstetricians and Gynaecologists of Canada. Diagnosis, Evaluation, and Management of the Hypertensive Disorders of Pregnancy. Journal of Obstetrics and Gynaecology Canada. March 2008; 30 (3). Suppl. 1.
23. Vikse B.E., Hallan S., Bostad L., Lei-vestad T. Previous preeclampsia and risk for progression of biopsy-verified kidney disease to end-stage renal disease. J Nephrol Dial Transplant. 2010 Oct; 25 (10): 3289-3296.
24. Wikstrom A.K., Ekegren L., Karlsson M., Bergenheim M. Plazma levels of S-100 during pregnancy in women developing preeclampsia. Pregnancy Hypertension: An International Journal of Women’s Cardiovascular Health. October 2012; 2 (4): 398-402.
25. Yu X.D., Branch D.W., Karumanchi S.A. Preeclampsia and retinopathy of prematurity in preterm births. Pediatrics. 2012 Jul; 130 (1): e101-7.
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For citations:
Shakhbazova N.A. CLINICAL AND IMMUNOLOGICAL COURSE OF GESTATION DURING PREGNANCY INDUCED HYPERTENSION. Obstetrics, Gynecology and Reproduction. 2014;8(3):11-17. (In Russ.)
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