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COVID-19 and iron deficiency anemia: relationships of pathogenesis and therapy

https://doi.org/10.17749/2313-7347/ob.gyn.rep.2020.179

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Abstract

During pregnancy, a woman becomes more susceptible to respiratory and viral diseases, including novel coronavirus infection (COVID-19). Pregnancy exacerbates the acute inflammation typical to COVID-19, elevating a risk of developing cytokine storm, characterized by an avalanche-like spike of inflammation marker concentrations (C-reactive protein, interleukin-1 в, interleukin-6, interferon-Y, ferritin, erythrocyte sedimentation rate etc.). Cytokine storm increases a risk of pregnancy loss and contribute to formation of multiple organ dysfunction syndrome in pregnant women and fetus. In particular, erythrocyte degradation due to acute inflammation leads to hypoxia and uncontrolled inter-tissue iron redistribution. As a result, conditions are created simultaneously for developing pulmonary hemosiderosis and hemosiderosis of other tissues in pregnant woman and fetus, as well as for augmenting iron loss from the body, which exacerbates iron deficiency anemia (IDA). It is important to emphasize that a surge of ferritin level distinctive for severe COVID-19, does not indicate iron overload. Therefore, recommendations to cancel IDA correction and even to use iron chelators in COVID-19 may increase hypoxia and harm the health of pregnant women.

About the Authors

O. A. Gromova
Institute of Pharmacoinformatics, Federal Research Center «Informatics and Management», Russian Academy of Sciences; Big Data Storage and Analysis Center, Lomonosov Moscow State University
Russian Federation
Olga A. Gromova - MD, Dr Sci Med, Professor, Leading Researcher, Scientific Director, Institute of Pharmacoinformatics, Federal Research Center «Informatics and Management», Russian Academy of Sciences; Leading Researcher, Big Data Storage and Analysis Center, Lomonosov Moscow State University.
42 Vavilova Str., Moscow 119333; 1 Leninskie Gory, Moscow 119234.
Scopus Author ID: 7003589812
Researcher ID: J-4946-2017
Author ID: 94901. WOS ID: J-4946-2017


I. Yu. Torshin
Institute of Pharmacoinformatics, Federal Research Center «Informatics and Management», Russian Academy of Sciences; Big Data Storage and Analysis Center, Lomonosov Moscow State University
Russian Federation
Ivan Yu. Torshin - PhD (Chemistry), PhD in Applied Mathematics, Senior Researcher, Institute of Pharmacoinformatics, Federal Research Center «Informatics and Management», Russian Academy of Sciences; Senior Researcher, Big Data Storage and Analysis Center, Lomonosov Moscow State University.
42 Vavilova Str., Moscow 119333; 1 Leninskie Gory, Moscow 119234.
Scopus Author ID: 7003300274
Researcher ID: C-7683-2018
Author ID: 54104. WOS ID: C-7683-2018


Yu. O. Shapovalova
Lapino Clinic Hospital, MD Medical Group
Russian Federation
Yuliya O. Shapovalova - MD, Obstetrician-Gynecologist, Lapino Clinic Hospital, MD Medical Group.
42 Vavilova Str., Moscow 119333; 1 Leninskie Gory, Moscow 119234.


M. A. Kurtser
Pirogov Russian National Research Medical University, Health Ministry of Russian Federation
Russian Federation
Mark A. Kurtser - MD, Dr Sci Med, Professor, Academician of RAS, Head of the Department of Obstetrics and Gynecology, Faculty of Pediatrics, Pirogov Russian National Research Medical University; General Director of MD Medical Group.
1 Ostrovityanova Str., Moscow 117997.


A. G. Chuchalin
Pirogov Russian National Research Medical University, Health Ministry of Russian Federation
Russian Federation
Alexander G. Chuchalin - MD, Dr Sci Med, Professor, Academician of RAS, Head of the Department of Hospital Therapy, Faculty of Pediatrics, Pirogov Russian National Research Medical University.
1 Ostrovityanova Str., Moscow 117997.


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For citation:


Gromova O.A., Torshin I.Yu., Shapovalova Yu.O., Kurtser M.A., Chuchalin A.G. COVID-19 and iron deficiency anemia: relationships of pathogenesis and therapy. Obstetrics, Gynecology and Reproduction. 2020;14(5):644-655. (In Russ.) https://doi.org/10.17749/2313-7347/ob.gyn.rep.2020.179

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ISSN 2313-7347 (Print)
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