ELIMINATION OF CHRONIC PELVIC PAIN CAUSED BY ADENOMYOSIS THE PROGESTOGENS NEW GENERATION
Abstract
Endometriosis, with more than centenary history, remains a challenge in our day. One of the more common options is adenomyosis, the share of which amounts to 80%. The aim of the study was to evaluate the clinical effectiveness and tolerance to resolve with chronic pelvic pain syndrome of adenomyosis the use of progestogen-new generation dienogest in a dose of 2 mg for 6 months. The study included 44 (n=44) women of reproductive age with a diagnosis of adenomyosis with chronic pelvic pain syndrome of various degrees of severity, whose average age was on average 36 yo 2 years who received therapy with dienogest in a daily dose of 2 mg for 6 months. The results showed high therapeutic
efficiency dienogest in the treatment of pelvic pain caused by adenomyosis.
efficiency dienogest in the treatment of pelvic pain caused by adenomyosis.
About the Authors
M. R. Orazov
Research Institute of medical family problems, Donetsk national medical University named after M. Gorky (Donetsk, Ukraine)
Ukraine
Ukraine
A. V. Chayka
Research Institute of medical family problems, Donetsk national medical University named after M. Gorky (Donetsk, Ukraine)
Ukraine
Ukraine
E. N. Nosenko
Research Institute of medical family problems, Donetsk national medical University named after M. Gorky (Donetsk, Ukraine)
Ukraine
Ukraine
References
1. Adamyan L.V., Kulakov V.I., Andreeva E.N. Endometriosis. Ed. 2. [Endometriozy. M.: Meditsina. Izd. 2-e]. Moscow. 2007; 416.
2. Anichkov N.M., Pechenikova V.A. Arkhiv patologii. 2005; 67 (3): 31-34.
3. Afonin A.V., Drapkina O.M., Kolbin A.S., Pchelintsev M.V., Ivashkin V.T. Russkii meditsinskii zhurnal. 2010; 18 (13): 845-9.
4. Baranskaya E.K. Farmateka. 2005; 14: 49-57.
5. Baskakov V.P., Tsvelev Yu.V., Kira E.F. Endometrial disease. St. Petersburg [Endometrioidnaya bolezn'. SPb]. 2002; 452 s.
6. Burlev V.A., Pavlovich S.V. Problemy reproduktsii. 2003; (2): 42-47.
7. Davydov A.I., Strizhakov M.A., Orlov O.N. Voprosy akusherstva, ginekologii i perinatologii. 2004; 4 (2): 40-46.
8. Damirov M.M. Adenomyosis [Adenomioz]. Moscow. 2004; 320 s.
9. Sidorova I.S., Kogan E.A., Zairat'yants O.V. i dr. Akusherstvo i ginekologiya. 2002; 3: 32-38.
10. Ishchenko A.I., Kudrina E.A. Endometriosis: diagnosis and treatment [Endometrioz: diagnostika i lechenie]. Moscow. 2002. 104 s.
11. Ivashkin V.T., Shul'pekova Yu.O. Rossiiskii zhurnal gastroenterologii, gepatologii, koloproktologii. 2002; 4: 16-21.
12. Kondrikov N.I. Akusherstvo i ginekologiya. 1999; 4: 10-13.
13. Kutsenko I.I. Arkh. patologii. 1997; 59 (5): 36-39.
14. Pal'tsev M.A., Severin E.S., Ivanov A.A. Arkhiv patologii. 2006; 4: 3-8.
15. Savitskii G.A., Gorbushin S.M. Peritoneal endometriosis and infertility (clinico-morpholo gical study) [Peritoneal'nyi endometrioz i besplodie (kliniko-morfologicheskoe issledovanie)]. St. Petersburg. 2002; 170 s.
16. Sidorova I.S., Unanyan A.L. Akusherstvo, ginekologiya i reproduktsiya. 2011; 1: 29-32.
17. Strizhakov A.N., Davydov A.I. Endometriosis. Clinical and theoretical aspects [Endometrioz. Klinicheskie i teoreticheskie aspekty]. Moscow. 1996; 330 s.
18. Sukhikh G.T., Sotnikova N.Yu., Antsiferova Yu.S., Posiseeva L.V., Veryasov V.N., Van'ko L.V. Byulleten' eksperimental'noi biologii i meditsiny. 2004; 137 (6): 646 s.
19. Unanyan A.L., Sidorova I.S., Kogan E.A. Akusherstvo, ginekologiya i reproduktsiya. 2012; 2: 25-30.
20. Unanyan A.L., Sidorova I.S., Kogan E.A. Akusherstvo, ginekologiya i reproduktsiya. 2012; 2: 25-30.
21. Yarmolinskaya M.I. Genital'nyi endometrioz: vliyanie gormonal'nykh, immunologicheskikhi geneticheskikh faktorov na razvitie, osobennosti techeniya i vybor terapii. Dokt, Diss. (Endometriosis: the impact of hormonal, immunologicheskihi genetic factors on the development, the course and the choice of therapy). Dr. diss. St. Petersburg. 2009. 40 s.
22. Bettendorf B., Shay S., Tu F. Dysmenorrhea: contemporary perspectives. Obstet Gynecol. Surv. 2008; 63 (9): 597-603.
23. Bhutta H.Y., Walsh S.R., Tang T.Y. Ovarian vein syndrome: a review. Int. J. Surg. 2009; 156 (7): 516-520.
24. Burney R.O., Talbi S., Hamilton A.E Gene expression analysis of endometrium reveals progesterone resistance and candidatesusceptibility genes in women with endometriosis. Endocrinology. 2003; 144: 2870-2881.
25. Chronic pelvic pain. ACOG Practice Bulletin Number 51. American College of Obstetricians andGynecologists. Obstet. Gynecol. 2008; 103: 589-605.
26. Giudice L.C. Clinical Practice. Endometriosis. N. Engl. J. Med. 2010 Jun 24; 362: 2389-2398.
27. Guo S.V. Recurrence of endometriosis and its control. Hum. Reprod. Update. 2009; 15: 441-461.
28. Harada T., Taniguchi F. Dienogest: a new therapeutic agent for the treatment of endometriosis. Jpn. Pharmacol. Ther. 2007; 35: 769-783.
29. Hovard F.M. Chronic pelvic pain. Clinical gynecologic series: an experts view. Obstet Gynecol. 2003; 101: 594-611.
30. Kennedy S., Bergqvist A., Chapron C. et al; ESHRE Special Interest Group for Endometriosisand Endometrium Guideline Development Group. ESHRE guideline for thediagnosis and treatment of endometriosis. Hum Reprod. 2005; 20 (10): 2698-704.
31. Vercellini P., Fedele L., Pietropaolo G. et al. Progestogtns for endometriosis: forward to the past. Hum. Reprod. Update. 2003; 9: 387-396.
32. Zeitoun K., Takayama K., Sasano H. Deficient 17 beta-hydroxysteroid dehydro genase type 2 expression in endometriosis: failure to metabolize 17 beta-estradiol. J. Clin. Endocrinol. Metab.1998; 83: 4474-4480.
33.
34.
Review
For citations:
Orazov M.R., Chayka A.V., Nosenko E.N. ELIMINATION OF CHRONIC PELVIC PAIN CAUSED BY ADENOMYOSIS THE PROGESTOGENS NEW GENERATION. Obstetrics, Gynecology and Reproduction. 2014;8(3):6-10. (In Russ.)
Views:
560
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Email this article 
