ON THE ISSUE OF PROTEIN C SYSTEM DISORDERS IN PREGNANT WOMEN WITH VARIOUS OBSTETRIC PATHOLOGY IN PAST HISTORY
Abstract
This article is focused on the pathophysiology, prevalence , clinical manifestations, diagnosis, and treatment C deficiency with increased risk of thrombosis. Activated protein C (aPC) exerts its anticoagulant activity through inactivation of coagulation factors Va and VIIIa. Aside its anticoagulant property, aPC demonstrates anti-inflammatory and cytoprotectiveeffects, which are mediated through the endothelial protein C receptor and the protease-activated receptor-I (PAR-1). Studying and understanding the biological function of APS makes it possible to control coagulation and inflammation and to apply protein C preparations as anticoagulant and cytoprotective drugs in a physicians clinical
practice.
practice.
About the Author
I. A. Mikhaylidi
The State Education Institution of Higher Professional Training The First Sechenov Moscow State Medical University under Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
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For citations:
Mikhaylidi I.A. ON THE ISSUE OF PROTEIN C SYSTEM DISORDERS IN PREGNANT WOMEN WITH VARIOUS OBSTETRIC PATHOLOGY IN PAST HISTORY. Obstetrics, Gynecology and Reproduction. 2014;8(3):59-64. (In Russ.)
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