Obstetrics, Gynecology and Reproduction

Advanced search


Full Text:


Pregnancy and childbirth in women with genetic or acquired thrombophilia is usually associated with a high risk to both thrombotic and obstetric complications and fruit. Unambiguous answer to the question of routine screening for thrombophilia in women with a history of obstetric history does not exist until now. It should be noted that the physiological hypercoagulable inherent pregnant, often for the first time reveals the background congenital and / or acquired disorders of hemostasis, which previously could be asymptomatic. A history of fetal loss syndrome, severe obstetric complications (severe preeclampsia, severe  twin-platsentranoy failure, fetal death, premature detachment of the placenta), thromboembolism is an indication for the study of genetic thrombophilia and antiphospholipid syndrome.

About the Author

D. L. Kapanadze
First Moscow State Medical Sechenov University of the Ministry of Health Russian Federation
Russian Federation


1. Thromboembolic complications in obstetric practice: systematization of approaches to therapy. Proceedings of the XIV All-Russian Scientific Forum «Mother and Child» [Tromboembolicheskie oslozhneniya v akushersko-ginekologicheskoi praktike: sistematizatsiya podkhodov k terapii]. Akusherstvo, ginekologiya i reproduktsiya. 2013; 3: 55-56.

2. Alfirevic Z., Roberts D. et al. How strong is the association between maternal thrombophilia and adverse pregnancy outcomes. A systematic review. Eur. J. Obstet. Gyn. Reprod. Biol. 2002; 101 (1): 6-14.

3. Bonnar J., Redman C.W., Denson K.W. The rol of coagulation and fibrinolysis in preeclampsia. Perspect. Nephrol. Hypertens. 1976; 5: 85-93.

4. Brenner B. Haemostatic changes in pregnancy. Thromb Res 2004; 114 (5-6): 409-414.

5. Dolitzky M., Inbal A., Brenner B. et al. A randomized study of thromboprophilaxis in women with unexplained consecutive recurrent miscarriages. Fertil. Steril. 2006; 86: 362.

6. Glueck C.J., Kupferninc N.J. et al. Genetic hypofibrinolisis in complicated pregnancies. Obstet. Gynecol. 2001 Jan; 97 (1): 44-8.

7. Gris J.C., Mercier E. et al. Low-molecularweight heparin versus low-dose aspirin in women with one fetal loss and a constitutional thrombophilic disorder. Blood. 2004; 103 (10): 3695-3699.

8. Greet I.A., Nelson-Piercy C. Low-molecularweight heparins for thromboprophylaxis and treatment of venous thromboembolism in pregnancy: a systematic review. Blood. 2005; 106:401-7.

9. Jespersen J. Plasma resistance to activated protein C: an important link, between venous thromboembolism and combined oral contraceptives – a short review. Eur. J. Contracept. Reprod. Health Care. 1996; 1: 3-11.

10. Kovac M., Mitic G. et al. Thrombophilia in women with pregnancy-associated complications: fetal loss and pregnancy-related venous thromboembolism. Gynecol. Obstet. Invest. 2010; 69 (4): 233-8.

11. Kupferminc M.J. Thrombophilia and pregnancy. Reprod. Biol. Endocrinol. 2003; 1: 111.

12. Kupferminc M.J., Fait G. et al. Low-molecularweight heparin for the prevention of obstetric complications in women with thrombophilias. Hypertens. Pregnancy. 2001; 20 (1): 35-44.

13. Lanir N., Aharon A., Brenner B. Haemostatic machanisms in human placenta. Best. Pract. Res. Clin. Haematol. 2003; 16 (2): 183-195.

14. Mosnier L.O., Zlokovic B.V., Griffin J.H. The cytoprotective protein C pathway. Blood. 2007; 109: 3161-3172.

15. Rey E., Garnean P. et al. Dalteparin for the prevention of recurrence of placenta-medicated complications of pregnancy in women without thrombophilia: a pilot randomized coutrolled trial. J. Thromb. Haemost. 2009; 7 (1): 58-64.

16. Riyazi N., Leeda M. et al. Low-molecularweight heparin combined with aspirin in pregnant women with thrombophilia and a history of preeclampsia or fetal growth restriction: a preliminary study. Eur. J. Obstet. Gynecol. Reprod. Biol. 1998; 80 (1): 49-54.

17. Robertson L., Wu O., Langhorne P. et al. Thrombophilia in pregnancy: a systematic review. Br. J. Haematol. 2005; 132: 171-96.

18. Rosendaal F.R. et al. Estrogens, Progesterons and Thrombosis. J. Thromb. Hemost. 2003; 1: 1371-80.

19. Zoller B., Garcia D.F., Dahlback B. Thrombophilia as a multigenic disease. Haematologica. 1999; 84:59-70.



For citation:

Kapanadze D.L. PREGNANCY AND CHILDBIRTH IN A YOUNG WOMAN WITH CONCOMITANT MUTATION IN LEIDEN AND PROTHROMBIN GENE G20210A. Obstetrics, Gynecology and Reproduction. 2014;8(2):34-38. (In Russ.)

Views: 497

ISSN 2313-7347 (Print)
ISSN 2500-3194 (Online)