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A systematic analysis of vascular paroxysm pathophysiology in perimenopause: methods for nutritional correction

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Materials and Methods. A systematic analysis of publications retrieved from PubMed/MEDLINE database as well as in the list of primary sources of the identified scientific papers was carried out by using current methods for large data analysis within the framework of topological and metric approaches applied for data recognition/classification. A map of molecular-pathophysiological processes was compiled followed by performing analysis of metric condensations.

Results. Three clusters of terms describing an impact of various biological processes into the pathophysiology of hot flushes were identified: inflammation combined with insulin resistance (cluster 1), the presence of chronic comorbid pathologies in patients (cluster 2), and disorders of serotonin metabolism (cluster 3). The use of menopausal hormone therapy (MHT) is not accepted for all patients. A promising direction in treatment of mild and moderate hot flushes is based on using nutraceuticals: vitamins, trace elements and substances obtained from plant extracts (isoflavones, phytoestrogens, etc.). Here, this set of interactions between pathophysiology of hot flushes and deficiency of certain micronutrients, inflammation, insulin resistance, chronic comorbid pathologies and disorders of serotonin metabolism is described. Replenished deficiency of vitamins C, E, A, B2, PP, B6, B12, and folates aids to reduce chronic inflammation, insulin resistance and normalize functioning of the autonomic nervous system. Natural and synthetic agonists of GABA receptors and tryptophan derivatives are necessary for serotonin biosynthesis and elimination of other neurotransmitter imbalances in order to normalize activity of the hypothalamic thermoregulatory region.

Conclusion. Plant isoflavones (including phytoestrogens) together with vitamins and other micronutrients help to overcome estrogen-dependent withdrawal symptoms and eliminate dysfunction of autonomic nervous system

About the Authors

O. A. Gromova
Institute of Pharmacoinformatics, Federal Research Center «Informatics and Management», Russian Academy of Sciences; Big Data Storage and Analysis Center, Lomonosov Moscow State University
Russian Federation

Olga A. Gromova - MD, Dr Sci Med, Professor, Leading Researcher, Scientific Director

42 Vavilova Str., Moscow 119333

1 Leninskie gory, Moscow 119234

Scopus Author ID: 7003589812

Researcher ID: J-4946-2017

Author ID: 94901. WOS ID: J-4946-2017

I. Yu. Torshin
Institute of Pharmacoinformatics, Federal Research Center «Informatics and Management», Russian Academy of Sciences; Big Data Storage and Analysis Center, Lomonosov Moscow State University
Russian Federation

Ivan Yu. Torshin - PhD (Chemistry), PhD in Applied Mathematics, Senior Researcher

42 Vavilova Str., Moscow 119333

1 Leninskie gory, Moscow 119234

Scopus Author ID: 7003300274

Researcher ID: C-7683-2018

Author ID: 54104

WOS ID: C-7683-2018

O. A. Limanova
Ivanovo State Medical Academy, Health Ministry of Russian Federation
Russian Federation

Olga A. Limanova - MD, PhD, Associate Professor, Department of Pharmacology

8 Sheremetyevskiy Ave., Ivanovo 153012

Scopus Author ID: 23013489000

WoS ID: A-7504-2016

N. I. Tapilskaya
Research Institute of Obstetrics, Gynecology and Reproductology named after D. O. Ott; Saint Petersburg State Pediatric Medical University, Health Ministry of Russian Federation
Russian Federation

Natalia I. Tapilskaya - MD, Dr Sci Med, Professor, Leading Researcher, Department of Assisted Reproductive Technologies; Professor, Department of Obstetrics and Gynecology

3 Mendeleevskaya liniya, Saint Petersburg 199034

2 Litovskaya Str., Saint Petersburg 194100

Scopus Author ID: 23013489000

WoS ID: A-7504-2016


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For citations:

Gromova O.A., Torshin I.Yu., Limanova O.A., Tapilskaya N.I. A systematic analysis of vascular paroxysm pathophysiology in perimenopause: methods for nutritional correction. Obstetrics, Gynecology and Reproduction. 2020;14(3):361-373. (In Russ.)

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