Obstetrics, Gynecology and Reproduction

Advanced search

Clinical and histological criteria for sex cord ovarian stromal tumors

Full Text:


Aim: to identify clinical and histological criteria for sex cord ovarian stromal tumors (OSTs).

Materials and Methods. The retrospective non-comparative study was based on the main inclusion such as histologically verified sex cord OSTs. A standard examination algorithm was analyzed (ultrasound, blood tests, CT or MRI of the abdominal and pelvic organs). All clinical data were obtained from patients treated and monitored in clinical units at the Blokhin National Medical Research Center of Oncology and the National Center of Oncology and Hematology of the Kyrgyz Republic.

Results. Data were obtained on the frequency of necrobiotic changes, malignancy, disease stages and their impact on survival in 456 patients. The 10-year survival rate for OSTs patients with vs. without intra-tumor necrobiotic changes was significantly lower (17.2 % and 78.1 %, respectively).

Conclusion. The main factors of unfavorable prognosis in patients with granulosa cell ovarian tumors were disease stage and intra-tumor necrobiotic changes.

About the Authors

A. М. Beishembaev
Kyrgyz State Medical Institute of Advanced Training and Retraining named after S. B. Daniyarov, Health Ministry of Kyrgyz Republic

Almaz М. Beishembaev - MD, PhD, Head of the Department of Oncology, Hematology, Radiation Diagnostics and Therapy

144а Bokonbaev Str., Bishkek 720064

K. I. Zhordania
N.N. Blokhin National Medical Research Center of Oncology, Health Ministry of Russian Federation
Russian Federation

Almaz М. Beishembaev - MD, PhD, Head of the Department of Oncology, Hematology, Radiation Diagnostics and Therapy

24 Kashirskoe Ave., Moscow 115478


1. Status of cancer care for the population of Russia in 2018. Eds. A. D. Kaprin, V. V. Starinskiy, G. V. Petrova. [Sostoyanie onkologicheskoj pomoshchi naseleniyu Rossii v 2018 godu. Pod red. A. D. Kaprina, V. V. Starinskogo, G. V. Petrovoj]. Moskva: MNIOI im. P. A. Gercena – filial NMIRC MZ RF, 2019. 236 s. (In Russ.). Available at: [Accessed: 01.03.2020].

2. Beishembaev A. M. Clinical and morphological features of adult granulosa cell tumors of the ovaries. [Kliniko-morfologicheskie osobennosti granulezokletochnyh opuholej yaichnikov vzroslogo tipa]. Zdravoohranenie Kyrgyzstana. 2018;(3):22–5. (In Russ.).

3. Beishembaev A. M., Lyubimova N. V., Abayev V. M. et al. Use of inhibin B in recurrent ovarian granulosa cell tumors. [Primenenie ingibina V pri recidivah granulezokletochnyh opuholej yaichnikov]. Opuholi zhenskoj reproduktivnoj sistemy. 2010;(3):68–72. (In Russ.).

4. Dridi M., Chraiet N., Batti R. et al. Granulosa cell tumor of the ovary: a retrospective study of 31 cases and a review of the literature. Int J Surg Oncol. 2018;2018:4547892.

5. Levin G., Zigron R., Haj-Yahya R. et al. Granulosa cell tumor of ovary: a systematic review of recent evidence. Eur J Obstet Gynecol Reprod Biol. 2018;225:57–61.

6. Li J., Bao R., Peng S., Zhang C. The molecular mechanism of ovarian granulosa cell tumors. J Ovarian Res. 2018;11(1):13.

7. Bedir R., Mürtezaoğlu A. R., Calapoğlu A. S. et al. Advanced stage ovarian juvenile granuloza cell tumor causing acute abdomen: a case report. Arch Iran Med. 2014;17(9):645–8.

8. Fresneau B., Orbach D., Faure-Conter C. et al. Sex-cord stromal tumors in children and teenagers: results of the TGM-95 study. Pediatr Blood Cancer. 2015;62(12):2114–9.

9. Thebaud E., Orbach D., Faure-Conter C. et al. Specificities of sex-cord stromal tumors in children and adolescents. Bull Cancer. 2015;102(6):550–8. (In French).

10. Cabrera-Cantú F., Urrutia-Osorio M., Valdez-Arellano F. et al. Sertoli-Leydig cell tumor in a 12-year-old girl: a review article and case report. Arch Gynecol Obstet. 2014;290(4):791–6.

11. Inam Z. S., Azizi A. H., Holland S. W. An 88-year-old woman with flushing, alopecia and hirsutism and a Sertoli-Leydig cell tumour. BMJ Case Rep. 2018;2018. pii: bcr-2017-222589.

12. Schneider D. T., Orbach D., Cecchetto G. et al. Ovarian Sertoli Leydig cell tumours in children and adolescents: an analysis of the European Cooperative Study Group on Pediatric Rare Tumors (EXPeRT). Eur J Cancer. 2015;51(4):543–50.

13. Zhang H. Y., Zhu J. E., Huang W., Zhu J. Clinicopathologic features of ovarian Sertoli-Leydig cell tumors. Int J Clin Exp Pathol. 2014;7(10):6956–64.

14. Zamurovic M., Soldo V., Cutura N. Bilateral poorly differentiated Sertoli-Leydig ovarian tumor associated with dysgerminoma: case report. Eur J Gynaecol Oncol. 2013;34(6):575–6.

15. Jang N. R., Lee D. H., Jang E. J. et al. Ovarian gynandroblastoma with a juvenile granulosa cell tumor component in a postmenopausal woman: a case report and literature review. J Pathol Transl Med. 2018;52(5):344–8.

16. McCluggage W.G., Young R. H. Ovarian sertoli-leydig cell tumors with pseudoendometrioid tubules (pseudoendometrioid sertoli-leydig cell tumors). Am J Surg Pathol. 2007;31(4):592–7.

17. Momin Y. A., Kulkarni M. P., Pandav A. B., Sulhyan K. R. Non Peutz- Jegher syndrome associated malignant sex cord stromal tumor with annular tubules. Int J Appl Basic Med Res. 2013;3(2):126–8.

18. Farinola M. A., Gown A. M., Judson K. et al. Estrogen receptor alpha and progesterone receptor expression in ovarian adult granulosa cell tumors and Sertoli-Leydig cell tumors. Int J Gynecol Pathol. 2007;26(4):375–82.

For citation:

Beishembaev A.М., Zhordania K.I. Clinical and histological criteria for sex cord ovarian stromal tumors. Obstetrics, Gynecology and Reproduction. 2020;14(3):261-268. (In Russ.)

Views: 99

ISSN 2313-7347 (Print)
ISSN 2500-3194 (Online)