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In spite of existing standards of hemorrhages prophylaxis maternal death from massive obstetric bleeding remains the main cause of maternal mortality in developing countries and even occurs in developed countries. The main risk factors of obstetrical bleedings are well known: placental abruption, placenta previa, uterus hypotonia, uterine rupture, amniotic fluid embolism, preeclampsia. However, these are only the tip of the iceberg. What is really assumed as a basis of majority of massive obstetric hemorrhages? From our view genetic thrombophilia, APS and hyperhomocysteinemia may be the etiopathogenetic risk factors of placental abruption, preeclampsia and respectively can be the cause of not only thromboembolic but hemorrhagic complications as well.

About the Authors

A. D. Makatsariya
First Moscow State Medical Sechenov University of the Ministry of Health Russian Federation
Russian Federation

V. O. Bitsadze
First Moscow State Medical Sechenov University of the Ministry of Health Russian Federation
Russian Federation

A. L. Mishenko
First Moscow State Medical Sechenov University of the Ministry of Health Russian Federation
Russian Federation


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For citation:

Makatsariya A.D., Bitsadze V.O., Mishenko A.L. HEMOSTASIS ABNORMALITIES AND MASSIVE OBSTETRIC BLEEDING. Obstetrics, Gynecology and Reproduction. 2014;8(2):17-26. (In Russ.)

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