HEMOSTASIS ABNORMALITIES AND MASSIVE OBSTETRIC BLEEDING
Abstract
In spite of existing standards of hemorrhages prophylaxis maternal death from massive obstetric bleeding remains the main cause of maternal mortality in developing countries and even occurs in developed countries. The main risk factors of obstetrical bleedings are well known: placental abruption, placenta previa, uterus hypotonia, uterine rupture, amniotic fluid embolism, preeclampsia. However, these are only the tip of the iceberg. What is really assumed as a basis of majority of massive obstetric hemorrhages? From our view genetic thrombophilia, APS and hyperhomocysteinemia may be the etiopathogenetic risk factors of placental abruption, preeclampsia and respectively can be the cause of not only thromboembolic but hemorrhagic complications as well.
About the Authors
A. D. Makatsariya
First Moscow State Medical Sechenov University of the Ministry of Health Russian Federation
Russian Federation
Russian Federation
V. O. Bitsadze
First Moscow State Medical Sechenov University of the Ministry of Health Russian Federation
Russian Federation
Russian Federation
A. L. Mishenko
First Moscow State Medical Sechenov University of the Ministry of Health Russian Federation
Russian Federation
Russian Federation
References
1. Serov V.N., Sukhikh G.T., Baranov N.I. Emergency conditions in obstetrics [Neotlozhnye sostoyaniya v akusherstve]. Moscow. 2011; 784 s.
2. Thrombohemorrhagic complications in obstetric practice: A Guide for Physicians / Ed. AD Makatsaria [Trombogemorragicheskie oslozhneniya v akushersko-ginekologicheskoi praktike: Rukovodstvo dlya vrachei / Pod red. A.D. Makatsariya]. Moscow. 2011; 1056 s.
3. Thrombotic and hemorrhagic complications in obstetrics. VN Serov, AD Makatsaria [Tromboticheskie i gemorragicheskie oslozhneniya v akusherstve. Serov V.N., A.D. Makatsariya]. Moscow. 1987; 288 s.
4. Bonnar J. Massive obstetric haemorrhage. Baillieres Best Pract. Res. Clin. Obstet. Gynaecol. 2000; 14: 1-18.
5. Bouwmeester F.W., Jonkhoff A.R., Verheijen R.H., van Geijn H.P. Successful treatment of life-threatening postpartum hemorrhage with recombinant activated factor VII. Obstet. Gynecol. 2003; 101: 1174-6.
6. Conklin K., Backus A. Physiological changes of pregnancy. In: Chestnut D.H., ed. Obstetric Anesthesia: Principles and Practice, 2nd Edn. St Louis: Mosby. 1999; 17-42.
7. El-Rafaey H., Rodeck C. Post-partum hemorrhage: definitions, medical and surgical management. A time for change. Br. Med. Bull. 2003; 67: 205-17.
8. James A.H., McLintock C., Lockhart E. Postpartum hemorrhage: when uterotonics and sutures fail. Am. J. Hematol. 2012; 87 (1): 16.
9. Joint statement of International Confederation of Midwives and International Federation of Gynecology and Obstetrics. Management of the third stage of labour to prevent postpartum hemorrhage. 2003. http://www.figo.org/content/PDF/PPHJointStatement.pdf
10. Kadir R.A., Kingman C.E., Chi C. et al. Is primary postpartum haemorrhage a good predictor of inherited bleeding disorders? Haemophilia. 2007; 13: 178.
11. McCormick M.L., Sanghvi H.C.G., Kinzie B., McIntosh N. Preventing postpartum hemorrhage in low-resource settings. International. Journal of Gynecology & Obstetrics. 2002; 77: 267-275.
12. Mousa H.A., Alfirevic Z. The Cochrane Library, Issue 3. Oxford: Update Software. Treatment for primary postpartum hemorrhage (Cochrane review). 2003.
13. Myers B., Pavord S., Kean L. et al. Pregnancy outcome in Factor XI deficiency: incidence of miscarriage, antenatal and postnatal haemorrhage in 33 women with Factor XI deficiency. BJOG. 2007; 114: 643.
14. Nichols W.L., Hultin M.B., James A.H. et al. von Willebrand disease (VWD): evidence-based diagnosis and management guidelines, the National Heart, Lung, and Blood Institute (NHLBI) Expert Panel report (USA). Haemophilia. 2008; 14: 171.
15. Prata N., Gerdts C. Measurement of postpartum blood loss. BMJ. 2010; 340: 555.
16. Rizvi F., Mackey R., Barrett T., McKenna P., Geary M. Successful reduction of massive postpartum haemorrhage by use of guidelines and staff education. Br. J. Obstet. Gynecol. 2004; 111: 495-8.
17. Thorsteinsson V.T., Kempers R.D. Delayed postpartum bleeding. Am. J. Obstet. Gynecol. 1970; 107: 565.
18. Tsu V.D., Langer A., Aldrich T. Postpartum hemorrhage in developing countries: is the public health community using the right tools? Int. J. Gynaecol. Obstet. 2004; 85 (1): 42-51.
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For citation:
Makatsariya A.D., Bitsadze V.O., Mishenko A.L. HEMOSTASIS ABNORMALITIES AND MASSIVE OBSTETRIC BLEEDING. Obstetrics, Gynecology and Reproduction. 2014;8(2):17-26. (In Russ.)
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