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Pregnancy and Zika virus

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Zika virus (ZIKV) is an arthropod-borne virus (arbovirus) in the genus Flavivirus and the Flaviviridae family. In 1947 and 1948 ZIKV was first isolated from a nonhuman primate as well as from mosquitoes in Africa, respectively. For half a century, ZIKV infections in human were sporadic prior to 2015–2016 pandemic spreading. Transmission of ZIKV from mother to fetus can occur in any trimester of pregnancy, even if mother was an asymptomatic carrier. The clinical signs of ZIKV infection are nonspecific and can be misdiagnosed as some other infectious diseases, especially those caused by arboviruses such as Dengue and Chikungunya. ZIKV infection was solely associated with mild illness prior to the large French Polynesian and Brazil outbreaks, when severe neurological complications, Guillain–Barre syndrome and dramatically increased rate of severe congenital malformations (including microcephaly) were reported. The adaptation of ZIKV to an urban cycle in endemic areas suggests that the incidence of ZIKV infections may be underestimated. The pandemic of novel coronavirus infection (COVID-19) demonstrates that lessons from ZIKV pandemic propagation has not been learned properly.

About the Authors

T. V. Startseva
Sechenov University
Russian Federation

Tatiana V. Startseva – 6th year Student, Faculty of Pediatrics

62 Str. Zemlyanoi Val, Moscow 109004

N. N. Kanshina
Sechenov University
Russian Federation

Nina N. Kanshina – MD, PhD, Associate Professor, Department of Infectious Diseases

62 Str. Zemlyanoi Val, Moscow 109004

M. V. Tretyakova
«Medical Center» LLC
Russian Federation

Maria V. Tretyakova – MD, PhD, Obstetrician-Gynecologist, Department of Gynecology

15/1 Timura Frunze Str., Moscow 119021

V. O. Bitsadze
Sechenov University
Russian Federation

Viktoria O. Bitsadze – MD, Dr Sci Med, Professor of RAS, Professor, Department of Obstetrics and Gynecology, N.F. Filatov Clinical Institute of Children’s Health

62 Str. Zemlyanoi Val, Moscow 109004

Scopus Author ID: 6506003478

Researcher ID: F-8409-2017

J. Kh. Khizroeva
Sechenov University
Russian Federation

Jamilya Kh. Khizroeva – MD, Dr Sci Med, Professor, Department of Obstetrics and Gynecology, N.F. Filatov Clinical Institute of Children’s Health

62 Str. Zemlyanoi Val, Moscow 109004

Scopus Author ID: 57194547147

Researcher ID: F-8384-2017


L. S. Radetskaya
Sechenov University
Russian Federation

Liudmila S. Radetskaya – MD, PhD, Associate Professor, Department of Obstetrics and Gynecology, N.F. Filatov Clinical Institute of Children’s Health

62 Str. Zemlyanoi Val, Moscow 109004

N. S. Stuleva
Sechenov University
Russian Federation

Nadezhda S. Stuleva – MD, PhD, Associate Professor, Department of Obstetrics and Gynecology, N.F. Filatov Clinical Institute of Children’s Health

62 Str. Zemlyanoi Val, Moscow 109004

Researcher ID: F-8694-2017


V. I. Tsibizova
Almazov National Medical Research Centre, Health Ministry of Russian Federation
Russian Federation

Valentina I. Tsibizova – MD, Department of Functional and Ultrasound Diagnostics

2 Akkuratova Str., Saint Petersburg 197341

A. S. Shkoda
City Clinical Hospital № 67 named after L.A. Vorokhobov, Moscow Healthcare Department
Russian Federation

Andrey S. Shkoda – MD, Dr Sci Med, Professor, Chief Physician

2/44 Salyama Adilya Str., Moscow 123423

D. V. Blinov
Institute for Preventive and Social Medicine; Lapino Clinic Hospital, MD Medical Group; Moscow Haass Medical – Social Institute
Russian Federation

Dmitry V. Blinov – MD, PhD, MBA, Head of Medical and Scientific Affairs, Institute of Preventive and Social Medicine; Neurologist, Lapino Clinic Hospital, MD Medical Group; Faculty Member, Department of Neurology, Psychiatry and Narcology, Moscow Haass Medical–Social Institute

4–10 Sadovaya-Triumfalnaya Str., Moscow 127006,
1st Uspenskoye Highway, 111, Moscow Region, Odintsovo District, Lapino 143081,
5, 1–1a 2nd Brestskaya Str., Moscow 123056

Researcher ID: E-8906-2017

RSCI: 9779-8290

A. D. Makatsariya
Sechenov University
Russian Federation

Alexander D. Makatsariya – MD, Dr Sci Med, Professor, Academician of RAS, Head of the Department of Obstetrics and Gynecology, N.F. Filatov Clinical Institute of Children’s Health

62 Str. Zemlyanoi Val, Moscow 109004

Scopus Author ID: 6602363216

Researcher ID: M-5660-2016


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For citation:

Startseva T.V., Kanshina N.N., Tretyakova M.V., Bitsadze V.O., Khizroeva J.K., Radetskaya L.S., Stuleva N.S., Tsibizova V.I., Shkoda A.S., Blinov D.V., Makatsariya A.D. Pregnancy and Zika virus. Obstetrics, Gynecology and Reproduction. 2020;14(2):229-238. (In Russ.)

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