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Laboratory monitoring of COVID-19 patients and importance of coagulopathy markers

https://doi.org/10.17749/2313-7347.141

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Abstract

The pandemic of a novel coronavirus infection COVID-19 has become a real challenge to the mankind and medical community and has raised a number of medical and social issues. Based on the currently available information on COVID-19 clinical cases, it follows that COVID-19 patients in critical condition exhibit a clinical picture of disseminated intravascular coagulation (DIC), septic shock with developing multiple organ failure, which justifies use of anticoagulant therapy in COVID-19 patients. In addition to isolating virus RNA from biological material and polymerase chain reaction diagnostics, use of simple and easily accessible laboratory blood markers is necessary for management of COVID-19 patients. If the activation of coagulation processes is sufficient enough, consumption of platelets and blood clotting factors can be diagnosed by laboratory methods as prolongation of routine blood clotting tests and increasing thrombocytopenia. Hyperfibrinogenemia, increased D-dimer level, prolonged prothrombin time, thrombocytopenia, lymphopenia, leukocytopenia, increased concentration of interleukin-6 and ferritin are observed in most COVID19 patients. The degree of increase in these changes correlates with severity of the inflammatory process and serves as a prognostically unfavorable sign. Here we discuss value of laboratory monitoring playing an essential role in such pathological crisis that contributes to patient screening, diagnosis as well as further monitoring, treatment and rehabilitation.

About the Authors

J. H. Khizroeva
Sechenov University
Russian Federation

Jamilya H. Khizroeva – MD, Dr Sci Med, Professor, Department of Obstetrics and Gynecology of Institute of Children's Health

62 Str. Zemlyanoi Val, Moscow 109004

Researcher ID: F-8384-2017 
Scopus Author ID: 57194547147 
eLibrary SPIN: 8225-4976

 



A. D. Makatsariya
Sechenov University
Russian Federation

Alexander D. Makatsariya, MD, Dr Sci Med, Academician of the Russian Academy of Sciences, Professor, Head of the Department of Obstetrics and Gynecology of Institute of Children's Health

62 Str. Zemlyanoi Val, Moscow 109004

Researcher ID: M-5660-2016. 
Scopus Author ID: 6602363216 
eLibrary SPIN: 7538-2966

 



V. O. Bitsadze
Sechenov University
Russian Federation

Victoria O. Bitsadze, MD, Dr Sci Med, Professor of the Russian Academy of Sciences, Professor of Obstetrics and Gynecology Department, Institute of Children's Health

62 Str. Zemlyanoi Val, Moscow 109004

Researcher ID: F-8409-2017
Scopus Author ID: 6506003478
eLibrary SPIN: 5930-0859

 



M. V. Tretyakova
«Medical Center» LLC
Russian Federation

Maria V. Tretyakova – MD, PhD, Obstetrician-Gynecologist, Department of Gynecology

15/1 Timura Frunze St., 119021, Moscow



E. V. Slukhanchuk
Petrovsky National Research Centre of Surgery
Russian Federation

Ekaterina V. Slukhanchuk – Head of the gynecological Department

2 Abrikosovsky pereulok, Moscow, 119991



I. Elalamy
Sechenov University; Medicine Sorbonne University; University of Montpellier
France

Ismail Elalamy – MD, Dr Sci Med, Professor, Department of Obstetrics and Gynecology, N. F. Filatov Clinical Institute of Children’s Health, Sechenov University; Professor, Medicine Sorbonne University; Director of Hematology, Department of Thrombosis Center, Hospital Tenon

62 Str. Zemlyanoi Val, Moscow 109004, 

12 Rue de l’École de Médecine, 75006 Paris, 

4 Rue de la Chine, 75020 Paris

Scopus Author ID: 7003652413
Researcher ID: AAC-9695-2019

 



J.-C. Gris
Sechenov University; Université de Montpellier
France

Jean-Christophe Gris – MD, Dr Sci Med, Professor, Department of Obstetrics and Gynecology, N. F. Filatov Clinical Institute of Children’s Health, Sechenov University; University of Montpellier

62 Str. Zemlyanoi Val, Moscow 109004, 

Paris

8Researcher ID: AAA-2923-2019



L. S. Radetskaya
Sechenov University
Russian Federation

Liudmila S. Radetskaya – MD, PhD, Associate Professor, Department of Obstetrics and Gynecology, N. F. Filatov Clinical Institute of Children’s Health

62 Str. Zemlyanoi Val, Moscow 109004



N. A. Makatsariya
Sechenov University
Russian Federation

Nataliya A. Makatsariya – MD, PhD, Associate Professor, Department of Obstetrics and Gynecology, N. F. Filatov Clinical Institute of Children’s Health

62 Str. Zemlyanoi Val, Moscow 109004



Ya. Yu. Sulina
Sechenov University
Russian Federation

Yana Yu. Sulina – MD, Assistant, Department of Obstetrics and Gynecology, N. F. Filatov Clinical Institute of Children’s Health

62 Str. Zemlyanoi Val, Moscow 109004

Scopus Author ID: 57194140583
ResearcherID: S-9569-2018

 



V. I. Tsibizova
Almazov National Medical Research Centre
Russian Federation

Valentina I. Tsibizova – MD, Departments of Functional and Ultrasound Diagnostics

2 Akkuratova Str., Saint Petersburg 197341



A. S. Shkoda
City Clinical Hospital No 67 named after L.A. Vorokhobov
Russian Federation

Andrey S. Shkoda – MD, Dr Sci Med, Professor, Chief Physician

2/44 Salyama Adilya St., Moscow 123423



D. V. Blinov
Institute for Preventive and Social Medicine; Lapino Clinic Hospital, MD Medical Group; Moscow Haass Medical – Social Institute
Russian Federation

Dmitry V. Blinov – MD, PhD, MBA, Head of Medical and Scientific Affairs, Institute of Preventive and Social Medicine; Neurologist, Lapino Clinic Hospital, MD Medical Group; Faculty Member, Department of Neurology, Psychiatry and Narcology, Moscow Haass Medical–Social Institute

4–10 Sadovaya-Triumfalnaya Str., Moscow 127006, 

1st Uspenskoye Highway, 111, Moscow Region, Odintsovo District, Lapino 143081, 

5, 1–1a 2nd Brestskaya Str., Moscow 123056

Researcher ID: E-8906-2017

 



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For citation:


Khizroeva J.H., Makatsariya A.D., Bitsadze V.O., Tretyakova M.V., Slukhanchuk E.V., Elalamy I., Gris J., Radetskaya L.S., Makatsariya N.A., Sulina Y.Yu., Tsibizova V.I., Shkoda A.S., Blinov D.V. Laboratory monitoring of COVID-19 patients and importance of coagulopathy markers. Obstetrics, Gynecology and Reproduction. 2020;14(2):132-147. https://doi.org/10.17749/2313-7347.141

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ISSN 2313-7347 (Print)
ISSN 2500-3194 (Online)