Preview

Obstetrics, Gynecology and Reproduction

Advanced search

Coronavirus disease (COVID-19) and disseminated intravascular coagulation syndrome

https://doi.org/10.17749/2313-7347.132

Full Text:

Abstract

COVID-19 is an infectious disease caused by the beta coronavirus SARS-CoV-2, which became widespread worldwide in 2020. In most severe patients, the clinical picture begins with respiratory failure, then progressing to polyorgan failure. The most adverse prognostic sign is the development of coagulopathy. Based on the analysis of clinical data available to date, 71.4% of those who died and 0.6% of those who survived showed signs of explicit disseminated intravascular coagulation syndrome (DIC-syndrome). Monitoring of D-dimer, prothrombin time (PT), platelet and fibrinogen count are important for determining treatment and indications for hospitalization among patients with COVID-19. If these parameters deteriorate, more "aggressive" intensive care should be performed. Lowmolecular weight heparin (LMWH) should be administered to all patients with diagnosed COVID-19 infection (including non-critical patients) who require hospitalization if these patients have no contraindications for LMWH.

About the Authors

A. D. Makatsariya
Sechenov University
Russian Federation

MD, Dr Sci Med, Professor, Academician of RAS, Head of the Department of Obstetrics and Gynecology, Institute of Children’s Health 

Scopus Author ID: 6602363216

Researcher ID: M-5660-2016

62 St. Zemlyanoi Val, Moscow 109004, Russia



K. N. Grigoreva
Sechenov University
Russian Federation
6th year Student, Faculty of Pediatrics

62 St. Zemlyanoi Val, Moscow 109004, Russia



M. A. Mingalimov
Sechenov University
Russian Federation
6th year Student, Institute of Children’s Health

62 St. Zemlyanoi Val, Moscow 109004, Russia



V. O. Bitsadze
Sechenov University
Russian Federation

MD, Dr Sci Med, Professor, Department of Obstetrics and Gynecology, Institute of Children’s Health

Scopus Author ID: 6506003478

Researcher ID: F-8409-2017

62 St. Zemlyanoi Val, Moscow 109004, Russia



J. Kh. Khizroeva
Sechenov University
Russian Federation
MD, Dr Sci Med, Professor, Department of Obstetrics and Gynecology, Institute of Children’s Health

62 St. Zemlyanoi Val, Moscow 109004, Russia



M. V. Tretyakova
«Medical Center» LLC
Russian Federation
PhD, Obstetrician-Gynecologist, Department of Gynecology

15/1 Timura Frunze St., Moscow 119021, Russia



I. Elalamy
Sechenov University; Medicine Sorbonne University; Hospital Tenon
Russian Federation

MD, PhD, Professor, Department of Obstetrics and Gynecology, Institute of Children’s Health; Professor; Director of
Hematology, Department of Thrombosis Center

Scopus Author ID: 7003652413

Researcher ID: AAC-9695-2019

62 St. Zemlyanoi Val, Moscow 109004, Russia

12 Rue de l’École de Médecine, 75006 Paris, France;

4 Rue de la Chine, 75020 Paris, France



A. S. Shkoda
City Clinical Hospital № 67 named after L.A. Vorokhobov, Moscow Healthcare Department;
Russian Federation
MD, PhD, Professor, Chief Physician

2/44 Salyama Adilya St., Moscow 123423, Russia



V. B. Nemirovskiy
City Clinical Hospital № 67 named after L.A. Vorokhobov, Moscow Healthcare Department;
Russian Federation

Head, Maternity Hospital #1, subdivision

2/44 Salyama Adilya St., Moscow 123423, Russia





D. V. Blinov
Institute for Preventive and Social Medicine, Lapino Clinic Hospital, MD Medical Group, Moscow Haass Medical – Social Institute
Russian Federation

MD, PhD, MBA, Head of Medical and Scientific Affairs; Neurologist; Faculty Member, Department of Neurology,
Psychiatry and Narcology

Researcher ID: E-8906-2017

RSCI: 9779-8290

4-10 Sadovaya-Triumfalnaya Str., Moscow 127006, Russia

1st Uspenskoye Highway, 111, Moscow Region, Odintsovo District, Lapino 143081, Russia

5 p. 1-1a 2nd Brestskaya Str., Moscow 123056, Russia



D. V. Mitryuk
State Medical and Pharmaceutical University «Nicolae Testemitanu» Republic of Moldova
Moldova, Republic of
 Аssistant, Department of Obstetrics and Gynecology

165, bul. Shtefan chel Mare, Kishinev, Republic of Moldova



References

1. World Health Organization. Novel Coronavirus — China. January 12, 2020 (https://www.who.int/csr/don/12-january-2020-novel-cor...).

2. Zhu N, Zhang D, Wang W, et al. A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med 2020;382:727-733.

3. Li Q, Guan X, Wu P, et al. Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia. N Engl J Med. 2020;NEJMoa2001316.4. Chan JF-W, Yuan S, Kok K-H, et al. A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating per-son-to-person transmission: a study of a family cluster. Lancet. 2020;395(10223):514-52

4. Levi M, van der Poll T. A short contemporary history of disseminated intravascular coagulation. Semin Thromb Hemost. 2014;40(8):874-880.

5. Boral B, Williams D, Boral L. Disseminated Intravascular Coagulation. Am J Clin Pathol. 2016;146(6):670-680.

6. Vaught A. Critical Care for the Obstetrician and Gynecologist: Obstetric Hemorrhage and Disseminated Intravascular Coagulopathy. Obstet Gynecol Clin North Am. 2016;43(4):611-622.

7. Levi M. Pathogenesis and diagnosis of disseminated intravascular coagulation. Int J Lab Hematol. 2018;40(Suppl 1):15-20.

8. Moellering R.C., Abbott G.F., Ferraro M.J. Case records of the Massachussets General Hospital Case 2-2011. A 30-year-old woman with shock after treatment for a furuncle. N Engl J Med. 2011;364(3):266–75. DOI: 10.1056/NEJMcpc1003886.

9. Russell J.A. Management of sepsis. N Engl J Med. 2006;355(16):1699–713. DOI: 10.1056/NEJMra043632.

10. Huang C, Wang Y, Li X, et al. Clinical features of patients in-fected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395(10223):497-506.

11. Guan WJ, Ni ZY, Hu Y, Liang WH, Ou CQ, He JX, et al China Medical Treatment Expert Group for COVID-19. Clinical Characteristics of Coronavirus Disease 2019 in China. N Engl J Med. 2020 Feb 28. doi: 10.1056/NEJMoa2002032.

12. Tang N, Li D, Wang X, Sun Z. Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia. J Thromb Haemost. 2020 epublished

13. Brun-Buisson C. et al. Incidence, risk factors, and outcome of severe sepsis and septic shock in adults: a multicenter prospective study in intensive care units. French ICU Group for Severe Sepsis . J.A.M.A. – 1995. – Vol. 274. – P. 968 – 974.

14. Vanderschueren S. et al. Thrombocytopenia and prognosis in intensive care .Crit. Care Med. – 2000. – Vol. 28. – P 1871 -1876.

15. Lippi G, Plebani M, Michael Henry B.Thrombocytopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: A meta-analysis. Clin Chim Acta. 2020 Mar 13. pii: S0009-8981(20)30124-8.

16. Wada H, Thachil J, Di Nisio M, Mathew P, Kurosawa S, Gando S, et al. Guidance for diagnosis and treatment of DIC from harmonization of the recommendations from three guidelines. The Scientific StandardizationCommittee on DIC of the International Society on Thrombosis Haemostasis. J Thromb Haemost. 2013 Feb 4. doi: 10.1111/jth.12155.

17. Taylor FB, Toh CH, Hoots WK, Wada H, Levi M. Towards definition, clinical and laboratory criteria, and a scoring system for disseminated intravascular coagulation. Thromb Haemost 2001; 86:1327– 30.

18. Levi M, Toh CH, Thachil J, Watson HG. Guidelines for the diagnosis and management of disseminated intravascular coagulation. British Committee for Standards in Haematology. Br J Haematol 2009; 145: 24– 33.

19. di Nisio M, Baudo F, Cosmi B, D'Angelo A, de Gasperi A, Malato A, et al, on behalf of the Italian Society for Thrombosis and Haemostasis. Diagnosis and treatment of disseminated intravascular coagulation: Guidelines of the Italian Society for Haemostasis and Thrombosis (SISET). Thromb Res 2012; 129: e177– 84

20. Gando S, Levi M, Toh C-H. Disseminated intravascular coagulation. Nat Rev Dis Prim. 2016;2(1):16037.

21. Ito T. PAMPs and DAMPs as triggers for DIC. J Intensive Care. 2014;2(1):65

22. Tang N. et al. Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy //Journal of Thrombosis and Haemostasis. – 2020. https://doi.org/10.1111/jth.14817

23. Iba T, Nisio MD, Levy JH, Kitamura N, Thachil J. New criteria for sepsisinduced coagulopathy (SIC) following the revised sepsis definition: a retrospective analysis of a nationwide survey. BMJ Open. 2017 Sep 27;7(9):e017046.

24. Poterucha TJ, Libby P, Goldhaber SZ. More than an anticoagulant: Do heparins have direct antiinflammatory effects? Thromb Haemost. 2017 Feb 28;117(3):437-444.


For citation:


Makatsariya A.D., Grigoreva K.N., Mingalimov M.A., Bitsadze V.O., Khizroeva J.K., Tretyakova M.V., Elalamy I., Shkoda A.S., Nemirovskiy V.B., Blinov D.V., Mitryuk D.V. Coronavirus disease (COVID-19) and disseminated intravascular coagulation syndrome. Obstetrics, Gynecology and Reproduction. 0;. (In Russ.) https://doi.org/10.17749/2313-7347.132

Views: 2502


ISSN 2313-7347 (Print)
ISSN 2500-3194 (Online)