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Coronavirus disease (COVID-19) and disseminated intravascular coagulation syndrome

https://doi.org/10.17749/2313-7347.132

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Abstract

COVID-19 is an infectious disease caused by the beta-coronavirus SARS-CoV-2 that in 2020 has spread worldwide. In most severe patients, the clinical picture begins with respiratory failure further deteriorating up to multiple organ failure. Development of coagulopathy is the most adverse prognostic. Analyzing currently available clinical data revealed that 71.4 % and 0.6 % of survivors and fatal cases, respectively, demonstrated signs of overt disseminated intravascular coagulation (DIC). Monitoring D-dimer level, prothrombin time, platelet count and fibrinogen content is important for determining indications for treatment and hospitalization in COVID-19 patients. In case such parameters deteriorate, a more pro-active “aggressive” intensive care should be applied. Low molecular weight heparin (LMWH) should be administered to all patients with diagnosed COVID-19 infection (including non-critical patients) requiring hospitalization, but having no contraindications to LMWH.



About the Authors

A. D. Makatsariya
Sechenov University
Russian Federation

Alexander D. Makatsariya – MD, Dr Sci Med, Professor, Academician of RAS, Head of the Department of Obstetrics and Gynecology, N. F. Filatov Clinical Institute of Children’s Health

62 St. Zemlyanoi Val, Moscow 109004

 Scopus Author ID: 6602363216

Researcher ID: M-5660-2016




K. N. Grigoreva
Sechenov University
Russian Federation

Kristina N. Grigoreva – 6th year Student, Faculty of Pediatrics

62 St. Zemlyanoi Val, Moscow 109004



M. A. Mingalimov
Sechenov University
Russian Federation

Marat A. Mingalimov – 6th year Student, N.F. Filatov Clinical Institute of Children’s Health

62 St. Zemlyanoi Val, Moscow 109004



V. O. Bitsadze
Sechenov University
Russian Federation

Victoria O. Bitsadze – MD, Dr Sci Med, Professor of RAS, Professor, Department of Obstetrics and Gynecology, N. F. Filatov Clinical Institute of Children’s Health

62 St. Zemlyanoi Val, Moscow 109004

Scopus Author ID: 6506003478

Researcher ID: F-8409-2017




J. Kh. Khizroeva
Sechenov University
Russian Federation

Jamilya Kh. Khizroeva – MD, Dr Sci Med, Professor, Department of Obstetrics and Gynecology, N. F. Filatov Clinical Institute of Children’s Health

62 St. Zemlyanoi Val, Moscow 109004



M. V. Tretyakova
«Medical Center» LLC
Russian Federation

Maria V. Tretyakova – MD, PhD, Obstetrician-Gynecologist, Department of Gynecology

15/1 Timura Frunze St., Moscow 119021



I. Elalamy
Sechenov University; Medicine Sorbonne University; Hospital Tenon
Russian Federation

Ismail Elalamy – MD, Dr Sci Med, Professor, Department of Obstetrics and Gynecology, N. F. Filatov Clinical Institute of Children’s Health, Sechenov University; Professor, Medicine Sorbonne University; Director of Hematology, Department of Thrombosis Center, Hospital Tenon

62 St. Zemlyanoi Val, Moscow 109004, 

12 Rue de l’École de Médecine, 75006 Paris, 

4 Rue de la Chine, 75020 Paris

Scopus Author ID: 7003652413

Researcher ID: AAC-9695-2019


 



A. S. Shkoda
City Clinical Hospital № 67 named after L.A. Vorokhobov, Moscow Healthcare Department;
Russian Federation

Andrey S. Shkoda – MD, Dr Sci Med, Professor, Chief Physician

2/44 Salyama Adilya St., Moscow 123423



V. B. Nemirovskiy
City Clinical Hospital № 67 named after L.A. Vorokhobov, Moscow Healthcare Department
Russian Federation

Vyacheslav B. Nemirovskiy – MD, PhD, Head of Maternity Hospital № 1, branch

2/44 Salyama Adilya St., Moscow 123423





D. V. Blinov
Institute for Preventive and Social Medicine; Lapino Clinic Hospital, MD Medical Group; Moscow Haass Medical – Social Institute
Russian Federation

Dmitry V. Blinov – MD, PhD, MBA, Head of Medical and Scientific Affairs, Institute of Preventive and Social Medicine; Neurologist, Lapino Clinic Hospital, MD Medical Group; Faculty Member, Department of Neurology, Psychiatry and Narcology, Moscow Haass Medical–Social Institute

4-10 Sadovaya-Triumfalnaya Str., Moscow 127006, 

1st Uspenskoye Highway, 111, Moscow Region, Odintsovo District, Lapino 143081, 

5 p. 1-1a 2nd Brestskaya Str., Moscow 123056

Researcher ID: E-8906-2017

RSCI: 9779-8290


 



D. V. Mitryuk
State Medical and Pharmaceutical University «Nicolae Testemitanu» Republic of Moldova
Moldova, Republic of

Diana V. Mitryuk – MD, Assistant, Department of Obstetrics and Gynecology

165 Вlvd. Stefan cel Mare, Kishinev MD 2004





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For citation:


Makatsariya A.D., Grigoreva K.N., Mingalimov M.A., Bitsadze V.O., Khizroeva J.K., Tretyakova M.V., Elalamy I., Shkoda A.S., Nemirovskiy V.B., Blinov D.V., Mitryuk D.V. Coronavirus disease (COVID-19) and disseminated intravascular coagulation syndrome. Obstetrics, Gynecology and Reproduction. 2020;14(2):123-131. (In Russ.) https://doi.org/10.17749/2313-7347.132

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ISSN 2313-7347 (Print)
ISSN 2500-3194 (Online)