Coronavirus disease (COVID-19) and disseminated intravascular coagulation syndrome
https://doi.org/10.17749/2313-7347.132
Abstract
COVID-19 is an infectious disease caused by the beta-coronavirus SARS-CoV-2 that in 2020 has spread worldwide. In most severe patients, the clinical picture begins with respiratory failure further deteriorating up to multiple organ failure. Development of coagulopathy is the most adverse prognostic. Analyzing currently available clinical data revealed that 71.4 % and 0.6 % of survivors and fatal cases, respectively, demonstrated signs of overt disseminated intravascular coagulation (DIC). Monitoring D-dimer level, prothrombin time, platelet count and fibrinogen content is important for determining indications for treatment and hospitalization in COVID-19 patients. In case such parameters deteriorate, a more pro-active “aggressive” intensive care should be applied. Low molecular weight heparin (LMWH) should be administered to all patients with diagnosed COVID-19 infection (including non-critical patients) requiring hospitalization, but having no contraindications to LMWH.
About the Authors
A. D. MakatsariyaRussian Federation
Alexander D. Makatsariya – MD, Dr Sci Med, Professor, Academician of RAS, Head of the Department of Obstetrics and Gynecology, N. F. Filatov Clinical Institute of Children’s Health
62 St. Zemlyanoi Val, Moscow 109004
Scopus Author ID: 6602363216
Researcher ID: M-5660-2016
K. N. Grigoreva
Russian Federation
Kristina N. Grigoreva – 6th year Student, Faculty of Pediatrics
62 St. Zemlyanoi Val, Moscow 109004M. A. Mingalimov
Russian Federation
Marat A. Mingalimov – 6th year Student, N.F. Filatov Clinical Institute of Children’s Health
62 St. Zemlyanoi Val, Moscow 109004V. O. Bitsadze
Russian Federation
Victoria O. Bitsadze – MD, Dr Sci Med, Professor of RAS, Professor, Department of Obstetrics and Gynecology, N. F. Filatov Clinical Institute of Children’s Health
62 St. Zemlyanoi Val, Moscow 109004
Scopus Author ID: 6506003478
Researcher ID: F-8409-2017
J. Kh. Khizroeva
Russian Federation
Jamilya Kh. Khizroeva – MD, Dr Sci Med, Professor, Department of Obstetrics and Gynecology, N. F. Filatov Clinical Institute of Children’s Health
62 St. Zemlyanoi Val, Moscow 109004M. V. Tretyakova
Russian Federation
Maria V. Tretyakova – MD, PhD, Obstetrician-Gynecologist, Department of Gynecology
15/1 Timura Frunze St., Moscow 119021I. Elalamy
Russian Federation
Ismail Elalamy – MD, Dr Sci Med, Professor, Department of Obstetrics and Gynecology, N. F. Filatov Clinical Institute of Children’s Health, Sechenov University; Professor, Medicine Sorbonne University; Director of Hematology, Department of Thrombosis Center, Hospital Tenon
62 St. Zemlyanoi Val, Moscow 109004,
12 Rue de l’École de Médecine, 75006 Paris,
4 Rue de la Chine, 75020 Paris
Scopus Author ID: 7003652413
Researcher ID: AAC-9695-2019
A. S. Shkoda
Russian Federation
Andrey S. Shkoda – MD, Dr Sci Med, Professor, Chief Physician
2/44 Salyama Adilya St., Moscow 123423V. B. Nemirovskiy
Russian Federation
Vyacheslav B. Nemirovskiy – MD, PhD, Head of Maternity Hospital № 1, branch
2/44 Salyama Adilya St., Moscow 123423
D. V. Blinov
Russian Federation
Dmitry V. Blinov – MD, PhD, MBA, Head of Medical and Scientific Affairs, Institute of Preventive and Social Medicine; Neurologist, Lapino Clinic Hospital, MD Medical Group; Faculty Member, Department of Neurology, Psychiatry and Narcology, Moscow Haass Medical–Social Institute
4-10 Sadovaya-Triumfalnaya Str., Moscow 127006,
1st Uspenskoye Highway, 111, Moscow Region, Odintsovo District, Lapino 143081,
5 p. 1-1a 2nd Brestskaya Str., Moscow 123056
Researcher ID: E-8906-2017
RSCI: 9779-8290
D. V. Mitryuk
Moldova, Republic of
Diana V. Mitryuk – MD, Assistant, Department of Obstetrics and Gynecology
165 Вlvd. Stefan cel Mare, Kishinev MD 2004
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Review
For citations:
Makatsariya A.D., Grigoreva K.N., Mingalimov M.A., Bitsadze V.O., Khizroeva J.Kh., Tretyakova M.V., Elalamy I., Shkoda A.S., Nemirovskiy V.B., Blinov D.V., Mitryuk D.V. Coronavirus disease (COVID-19) and disseminated intravascular coagulation syndrome. Obstetrics, Gynecology and Reproduction. 2020;14(2):123-131. https://doi.org/10.17749/2313-7347.132
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