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Disseminated intravascular coagulation in perinatal medicine

https://doi.org/10.17749/2313-7347.2020.14.1.56-68

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Abstract

Introduction. Disseminated intravascular coagulation (DIC) is an acquired syndrome characterized by intravascular activation of blood clotting without specific localization and arising from various causes. DIC is the most complex and high-priority problem in contemporary clinical medicine including obstetrics and perinatology. DIC significance is related to its peak perinatal mortality, as well as a large rate of complications during childbirth and postpartum period.

Aim: to conduct comprehensive data assessment related to DIC pathogenesis and management in pregnant women and newborns.

Materials and methods. A search for DIC-related publications within the past 10 years was conducted in international research databases: Scientific Electronic Library Online eLibrary, Google Scholar, ScienceDirect, Cochrane Library, PubMed/Medline. The data regarding DIC diagnostic criteria and markers, as well as current approach to its treatment are presented.

Results. DIC may be considered as one of the causes resulting in massive obstetric bleeding. The majority of pregnancy-related complications is manifested as preeclampsia, premature detachment of normally situated placenta and anaphylactoid syndrome of pregnancy. Any massive bleeding should be perceived as hemorrhage resulting from the DIC progression.

Conclusion. Knowledge of the DIC pathogenetic mechanisms is necessary for conducting a differential diagnosis and applying timely treatment.

About the Authors

M. A. Mingalimov
Sechenov University
Russian Federation

Marat A. Mingalimov - 6th year Student.

62 St. Zemlyanoi Val, Moscow 109004



K. N. Grigorieva
Sechenov University
Russian Federation

Kristina N. Grigoreva - 6th year Student, Faculty of Pediatrics.

62 St. Zemlyanoi Val, Moscow 109004



M. V. Tretyakova
Medical Center, LLC
Russian Federation

Maria V. Tretyakova - PhD, Obstetrician-Gynecologist, Department of Gynecology.

15/1 Timura Frunze St., Moscow 119021



I. Elalamy
Sechenov University; Medicine Sorbonne University; HospitaI Tenon
France

Ismail Elalamy - MD, PhD, Professor, Department of Obstetrics and Gynecology, Institute of Children's Health, SU; Professor, MSU; Director of Hematology, Department of Thrombosis Center, Hospital Tenon, Scopus Author ID: 7003652413, Researcher ID: AAC-9695-2019.



Kh. G. Sultangadzhieva
Sechenov University
Russian Federation

Khadizhat G. Sultangadzhieva - Postgraduate Student, Department of Obstetrics and Gynecology, Institute of Children's Health.

62 St. Zemlyanoi Val, Moscow 109004



V. O. Bitsadze
Sechenov University
Russian Federation

Victoria O. Bitsadze - MD, Dr Sci Med, Professor, Department of Obstetrics and Gynecology, Institute of Children's Health, Scopus Author ID: 6506003478, Researcher ID: F-8409-2017.

62 St. Zemlyanoi Val, Moscow 109004



J. Kh. Khizroeva
Sechenov University
Russian Federation

Jamilya Kh. Khizroeva - MD, Dr Sci Med, Professor, Department of Obstetrics and Gynecology, Institute of Children's Health.

62 St. Zemlyanoi Val, Moscow 109004



A. D. Makatsariya
Sechenov University
Russian Federation

Alexander D. Makatsariya - MD, Dr Sci Med, Professor, Academician of RAS, Head of the Department of Obstetrics and Gynecology, Institute of Children's Health, Scopus Author ID: 6602363216, Researcher ID: M-5660-2016.

62 St. Zemlyanoi Val, Moscow 109004



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For citation:


Mingalimov M.A., Grigorieva K.N., Tretyakova M.V., Elalamy I., Sultangadzhieva K.G., Bitsadze V.O., Khizroeva J.K., Makatsariya A.D. Disseminated intravascular coagulation in perinatal medicine. Obstetrics, Gynecology and Reproduction. 2020;14(1):56-68. (In Russ.) https://doi.org/10.17749/2313-7347.2020.14.1.56-68

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ISSN 2313-7347 (Print)
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