The effect of diet therapy on the anthropometric and metabolic parameters in women with infertility and obesity

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Aim: to monitor the anthropometric, hormonal and metabolic parameters in women of reproductive age with infertility and grade I gluteofemoral obesity during treatment with a balanced hypocaloric diet.

Materials and methods. The study included 23 infertile women of reproductive age. All patients were prescribed a balanced, low-calorie diet (1200 kcal/day), exercise, and behavioral therapy. The anthropometric, metabolic and hormonal parameters were determined before and 12 months after the treatment. We measured the levels of leptin, total cholesterol, triglycerides, triglycerides, high-density and low-density lipoprotein cholesterol (HDL cholesterol and LDL cholesterol), fasting glycose. Following the measurements, the atherogenic and insulin resistance indices were calculated. In addition, the plasma concentrations of luteinizing hormone, follicle-stimulating hormone, prolactin, estrone, estradiol, testosterone, progesterone, and immunoreactive insulin were measured.

Results. Twenty patients completed the study. A decrease in body weight (by average of 10.58 ± 5.70 kg) was found in 87 % of patients; in parallel, the body mass index decreased from 32.53 ± 1.40 to 28.55 ± 2.50 kg/m2 (p < 0.001). The decrease in body weight was accompanied by a statistically significant decrease in the levels of leptin (p < 0.001), estrone (p = 0.049), estradiol (p = 0.032), total cholesterol (p < 0.001), triglycerides (p = 0.004), LDL cholesterol (p = 0.001), fasting glycose (p < 0.001), insulin resistance index (p = 0.002), atherogenic index (p < 0.001) and an increase in the level of progesterone (p = 0.030). The ovulatory menstrual cycle was restored in all women (p = 0.007); within one year, wanted pregnancy occurred in 1 woman.

Conclusion. The use of a low-calorie diet for 12 months in infertile women with grade I gluteofemoral obesity leads to normalization of metabolic parameters, weight loss and, the restoration of the ovulatory menstrual cycle in 100 % of cases.

About the Authors

N. V. Artymuk
Kemerovo State Medical University, Health Ministry of Russian Federation
Russian Federation

Natalia V. Artymuk - MD, Dr Sci Med, Professor, Head of Department of Obstetrics and Gynecology named after Professor G.A. Ushakova.

22а Voroshilova St., Kemerovo 650056

O. A. Tachkova
Kemerovo State Medical University, Health Ministry of Russian Federation
Russian Federation

Olga A. Tachkova - PhD, Associate Professor, Department of Internal Medicine and Clinical Pharmacology.

22а Voroshilova St., Kemerovo 650056

N. A. Sukhova
Kemerovo State Medical University, Health Ministry of Russian Federation
Russian Federation

Natalia A. Sukhova - PhD, Associate Professor, Department of Internal Medicine and Clinical Pharmacology.

22а Voroshilova St., Kemerovo 650056


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For citations:

Artymuk N.V., Tachkova O.A., Sukhova N.A. The effect of diet therapy on the anthropometric and metabolic parameters in women with infertility and obesity. Obstetrics, Gynecology and Reproduction. 2020;14(1):7-14. (In Russ.)

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