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Clinical and histological features of purely stromal cell ovarian tumors

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Aim: to identify clinical and histologic features of pure stromal ovarian tumors.

Materials and methods. We analyzed the clinical data from patients treated and followed up at the Blokhin National Medical Research Center of Oncology and the National Center of Oncology and Hematology of the Kyrgyz Republic.

Results. Data on necrobiotic changes, malignancy, stages of the disease and the survival of 14 patients with pure stromal ovarian tumors have been obtained.

Conclusion. The main factors of unfavorable prognosis in patients with ovarian tecoma are tumor necrosis, degree of malignancy and mitotic activity.

About the Authors

A. M. Beishembaev
Kyrgyz State Medical Institute of Advanced Training and Retraining named after S.B. Daniyarov, Health Ministry of Kyrgyz Republic

Almaz М. Beishembaev – PhD, Head of the Department of Oncology, Hematology, Radiation Diagnostics and Therapy, Faculty of Advanced Medical Education

144а Bokonbaev St., Bishkek 720064, Kyrgyz Republic.

K. I. Zhordania
N.N. Blokhin National Medical Research Center of Oncology, Health Ministry of Russian Federation
Russian Federation

Kirill I. Zhordania – MD, PhD, Gynecologist-Oncologist, Leading Researcher, Department of Gynecology

24 Kashirskoe Av., Moscow 115478, Russia.


1. Shvachko S.A., Gritsay A.N., Lazareva N.I. et al. Ovarian sarcomas: literature review. [Sarkomy yaichnikov: obzor literatury]. Opuholi zhenskoj reproduktivnoj sistemy. 2010;(3):88–94. (In Russ.). DOI: 10.17650/1994-4098-2010-0-3-88-94.

2. Kaprin A.D., Starinskiy V.V., Petrova G.V. The status of cancer care for the population of Russia in 2018. [Sostoyanie onkologicheskoj pomoshchi naseleniyu Rossii v 2018 godu]. Moskva: MNIOI im. P.A. Gercena – filial NMIRC MZ RF, 2019. 231 s. (In Russ.). Available at:

3. Beishembaev A.M. Clinical and morphological features of adult granulosa cell tumors of the ovaries. [Kliniko-morfologicheskie osobennosti granulezokletochnyh opuholej yaichnikov vzroslogo tipa]. Zdravoohranenie Kyrgyzstana. 2018;(3):22–5. (In Russ.).

4. Ting Y., Yang L.I., Juan Z. et al. Ovarian thecoma with massive pleural effusion in postmenopausal women: A case report. Mol Clin Oncol. 2016;4(6):1003–5. DOI: 10.3892/mco.2016.853.

5. Burandt E., Young R.H. Thecoma of the ovary: a report of 70 cases emphasizing aspects of its histopathology different from those often portrayed and its differential diagnosis. Am J Surg Pathol. 2014;38(8):1023–32. DOI: 10.1097/PAS.0000000000000252.

6. Cha M.Y., Roh H.J., You S.K. et al. Meigs’ syndrome with elevated serum CA-125 level in a case of ovarian fibrothecoma. Eur J Gynaecol Oncol. 2014;35(6):734–7.

7. Chen H., Liu Y., Shen L.F. et al. Ovarian thecoma-fibroma groups: clinical and sonographic features with pathological comparison. J Ovarian Res. 2016;22;9(1):81. DOI: 10.1186/s13048-016-0291-2.

8. Kang M., Lee K.B., Park Y.H., Cho H.Y. First reported case of intrahepatic cholangiocarcinoma metastasis to thecoma. J Obstet Gynaecol. 2019;39(3):429–431. DOI: 10.1080/01443615.2018.1504901.

9. Muronda M., Russell P. Combined ovarian serous cystadenoma and thecoma. Pathology. 2018;50(3):367–9. DOI: 10.1016/j.pathol.2017.09.026.

10. Di Lorito A., Viola P., Rosini S., Lattanzio G. Cellular fibroma in the Douglas cavity, mimicking a malignant neoplasia: fibroma, fibrosarcomaor mitotically active cellular fibroma? Pathologica. 2016;108(1):34–7.

11. Ozdemir O., Sari M.E., Sen E. et al. Primary ovarian fibrosarcoma: a case report and review of the literature. J Exp Ther Oncol. 2016;11(3):225–35.

12. Alvarado-Cabrero I., Valencia-Cedillo R., Mohs-Alfaro M., De Anda- González J. Ovarian dysgerminoma associated with fibrosarcoma: a case report. Int J Gynecol Pathol. 2011;30(5):466–9. DOI: 10.1097/PGP.0b013e318217139e.

13. Zong L., Lin M., Fan X. Mitotically active cellular fibroma of ovary should be differentiated from fibrosarcoma: a case report and review of literature. Int J Clin Exp Pathol. 2014;7(11):7578–82.

14. Wang J., Papanastasopoulos P., Savage P. et al. A unique case of extraovarian sex-cord stromal fibrosarcoma, with subsequent relapse of differentiated sex-cord tumor. Int J Gynecol Pathol. 2015;34(4):363–8. DOI: 10.1097/PGP.0000000000000151.

15. Miura M., Suzuki S., Shibata K. et al. Estrogen producing ovarian fibrosarcoma: A case report. Nagoya J Med Sci. 2019;81(1):171–6. DOI: 10.18999/nagjms.81.1.171.

16. Mizumoto T., Toyama H., Asari S. et al. A case of recurrent ovarian fibrosarcoma resected by pancreaticoduodenectomy. Gan To Kagaku Ryoho. 2016;43(12):2193–5. (In Japanese).

17. Yazdani S., Alijanpoor A., Sharbatdaran M. et al. Meigs’ syndrome with elevated serum CA-125 in a case of ovarian fibroma/thecoma. Caspian J Intern Med. 2014;5(1):43–5.


For citations:

Beishembaev A.M., Zhordania K.I. Clinical and histological features of purely stromal cell ovarian tumors. Obstetrics, Gynecology and Reproduction. 2019;13(4):289-296. (In Russ.)

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ISSN 2313-7347 (Print)
ISSN 2500-3194 (Online)