Preview

Obstetrics, Gynecology and Reproduction

Advanced search

THE ROLE OF CIRCULATING ANTIPHOSPHOLIPID ANTIBODIES IN THE FETAL LOSS SYNDROME DEVELOPMENT

Abstract

The article describes the examination data of pregnant women with fetal loss syndrome in anamnesis which were analyzed for the circulated antiphospholipid antibodies. Reviewed approaches to prevention of obstetrics complication and antithrombotic prophylaxis with LMWH.

About the Author

M. S. Selkhadzhieva
The State Education Institution of Higher Professional Training The First Sechenov Moscow State Medical University under Ministry of Health of the Russian Federation
Russian Federation


References

1. Bicadze V.O. Patogenez, principy diagnostiki i profilaktiki oslozhnenij beremennosti, obuslovlennyh trombofiliej. Diss. …dokt. med. nauk. M. 2004; 271 s.

2. Gromyko G.L. Rol' antifosfolipidnogo sindroma v razvitii akusherskih oslozhnenij. Problemy reprodukcii. 1997; 4: 13-18.

3. Makacarija A.D. Antifosfolipidnyj sindrom M. 2000; 373 s.

4. Makacarija A.D., Bicadze V.O. Trombofilii i protivotromboticheskaja terapija v akusherskoj praktike. M. 2003; 904 s.

5. Matveeva T.E. Voprosy patogeneza i profilaktiki sindroma poteri ploda u beremennyh s trombofiliej. Diss. ...kand. med. nauk. M. 2002; 131 s.

6. Suhih G.L., Ponomareva I.V., Gorodnicheva Zh.A., Van'ko L.V. Spektr antifosfolipidnyh antitel u beremennyh s gestozom. Akusherstvo i ginekologija. 1998; 5: 22-26.

7. Amergual O., Atsumi T., Khamashta M.A, Tinohones F., Hughes G.R.V. Autoantibodies against oxidazed low density lipoprotein in antiphospholipid syndrome. Br. J. Rheumatol. 1997; 36: 964-968.

8. Backos M., Rai R., Baxter N., Chilcott I.T, Cohen H., Regan L. Pregnancy complications in women with recurrent miscarriage associated with antiphospholipid antibodies treated with low-dose aspirin and heparin. Br. Obstet Gynaecol. 1999; 106: 102-7.

9. Bates S.M., Greer I.A., Pabinger I., Sofaer S., Hirsh J. Venous Thromboembolism, Thrombophilia, Antithrombotic Therapy, and Pregnancy: Evidence-Based Clinical Practice Guidelines American College of Chest Physicians (8th Edition). Chest. 2008; 133; 844-886.

10. Botet F., Romera G., Montagut P., Figueras J., Carmona J., Balasch J. Neonatal outcome in women treated for the antiphospholipid syndrome during pregnancy. J. Perinat. Med. 1997; 25: 192-196.

11. Cowchock S. Antibodies and pregnancy loss. The New Eng. Journal of Medicine. July 17, 1997; 197-198.

12. de Laat B., Mertens K., de Groot Ph. Mechanisms of disease: antiphospholipid antibodies -from clinical association to pathologic mechanism nature clinical practice / B. de Laat, K. Mertens, Ph. de Groot. Rheumatology. 2008; 4 (4): 192-199.

13. Empson M., Lassere M., Craig J.C., Scott J.R. Recurrent pregnancy loss with antiphospholipid antibody: a systematic review of therapeutic trials. Obstet. Gynecol. 2002; 99:135-44.

14. Farquharson R.G., Quenby S., Greaves M. Antiphospholipid syndrome in pregnancy: a randomized, controlled trial of treatment. Obstet. Gynecol. 2002; l00: 408-13.

15. Gandra M.J., Fraga M., Saraiva J.P., Andrade J. Anticardiolipin antibodies and high risk pregnancy. 16th Congress on thromb and haemost. Porto. 2000; abstr. p. 160.

16. Genievskaya M., Makatsaria A. Low molecular weight heparin (Fraxiparine) as long-term single agent therapy in pregnant with antiphospholipid syndrome. 16th Congress oh thrombosis and haemostasis. Porto. 2000, abstr. p. 161.

17. Granger K.A., Farquharson R.G., Obstetric outcome in antiphosholipid syndrome. Lupus. 1997; 6: 509-513.

18. Honig A. Pregnancy-triggered antiphospholipid syndrome in a patient with multiple late miscarriages / A. Honig et al. Hum. Reprod. 2010; 25 (11): 2753-2754.

19. Levy R.A., Avvad E., Olivera J., Porto L.C. Placental pathology in antiphospholipid syndrome. Lupus. 1998; 7 (2): 81-85.

20. Lyden T.W., Vogt E., Ng A.K., Johnson P.M., Rote N.S. Monoclonal antiphospholipid antibody reactivity against human placental trophoblast. Reprod Immunol. 1992; 22: 1-14.

21. Zeev Blumenfeld, Benjamin Brenner. Thrombophilia-associated pregnancy wastage. Fertility and sterility. Nov. 1999; 72 (5): 765-774.

22.

23.


Review

For citations:


Selkhadzhieva M.S. THE ROLE OF CIRCULATING ANTIPHOSPHOLIPID ANTIBODIES IN THE FETAL LOSS SYNDROME DEVELOPMENT. Obstetrics, Gynecology and Reproduction. 2014;8(1):31-33. (In Russ.)

Views: 400


ISSN 2313-7347 (Print)
ISSN 2500-3194 (Online)