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ASSISTED REPRODUCTIVE TECHNOLOGY AND ANTIPHOSPHOLIPID SYNDROME

Abstract

The antiphospholipid antibodies (APA) exert multiple effects on the hemostasis system causing damage to all of its protective components including the endothelial barrier, natural anticoagulant function and endogenous fibrinolysis and activating the platelet phase of hemostasis, which is associated with numerous obstetrical complications and
infertility. The question is, what is the frequency of circulating APA in women who underwent IVF failure and whether there is a relationship between the presence of APA and poor reproduction outcome? This study aimed at elucidating the effect of the presence of APA on the outcomes of assisted reproductive technology (ART). A total of 267 women diagnosed with infertility and planning to get pregnant using the assisted reproductive technology (ART) have been examined. The results of examination demonstrated a high prevalence of circulating APA in a group of women who underwent IVF failure. High titers of APA were found in 42.1% of female patients who had undergone IVF failure. The fraction of women in whom fertility treatment using ART succeeded was 19.1%.

About the Authors

J. Kh. Khizroeva
Chair of Obstetrics and Gynaecology of Medical Prophylaxis Faculty of I.M. Sechenov First Moscow State Medical University
Russian Federation


T. M. Mashkova
Chair of Obstetrics and Gynaecology of Medical Prophylaxis Faculty of I.M. Sechenov First Moscow State Medical University
Russian Federation


References

1. Azem F., Many A., Yovel I., Amit A., Lessing J.B., Kupferminc M.J. Increased rates of thrombophilia in women with repeated IVF failures. Hum. Reprod. 2004; 19 (2): 368-70.

2. Chan W.S., Dixon M.E. The “ART” of thromboembolism: a review of assisted reproductive technology and thromboembolic complications. Thromb. Res. 2008; 121 (6): 713-26.

3. Di Simone N., Meroni P.L., del Papa N., Raschi E., Caliandro D., De Carolis C.S., Khamashta M.A., Atsumi T., Hughes G.R., Balestrieri G. et al. Antiphospholipid antibodies affect trophoblast gonadotrophin secretion and invasiveness by binding directly and through adhered beta2-glycoprotein I. Arthritis Rheum. 2000; 43: 140-150.

4. Di Simone N., Ferrazzani S., Castellani R., De Carolis S., Manscuso S. and Caruso A. Heparin and low dose aspirin restore placental human chorionic gonadotrophin secretion abolished by antiphospholipid antibody containing sera. Hum. Reprod., 1997; 12: 2061-2065.

5. Fleischer K., Von Vliet H.A., Rosendaal F.R, Rosing J., Tschaikivski S., Helmerhorst F.M. Effects of the contraceptive patch, the vaginal ring and an oral contraceptive on APC resistance and SHBG: a cross-over study. Thromb Res. 2009; 123 (3): 429-435.

6. Franklin R.D., Kutteh W.H. Antiphospholipid antibodies (APA) and recurrent pregnancy loss: treating a unique APA positive population. Hum. Reprod. 2002; 17: 2981-2985.

7. Kodama H., Fukuda H., Matsui T., Tanaka T. Status of the coagulation and fibrinolytic systems in ovarian hyperstimulation syndrome, Fertil Steril. 1996 Sep; 66 (3): 417-24.

8. Marcello de Nisio, Anne WS Rutjes, Noemi Ferrante, Gian Mario Tiboni, Franco Cuccurullo, Ettore Porreca. Thromophilia and outcomes of assisted reproduction technologies: a systematic review and meta-analysis. Blood. June 2011; 2670-78.

9. Nelson Sm. Venous thrombosis during assisted reproduction: novel risk reduction strategies. Thromb Res. 2013; 131 (1): 1-3.

10. Nelson S.M., Greer I.A. The potential role of heparin in assisted conception. Hum Reprod. Update. 2008 Nov-Dec; 14 (6): 623-45.

11. Qublan H.S., Eid S.S., Ababneh H.A., Amarin Z.O., Smadi A.Z., Al-Khafaji F.F., Khader Y.S. Acquired and inherited thrombophilia: implication in recurrent IVF and embryo transfer failure. Hum Reprod. 2006 Oct; 21 (10): 2694-8.


Review

For citations:


Khizroeva J.Kh., Mashkova T.M. ASSISTED REPRODUCTIVE TECHNOLOGY AND ANTIPHOSPHOLIPID SYNDROME. Obstetrics, Gynecology and Reproduction. 2014;8(1):26-30. (In Russ.)

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ISSN 2313-7347 (Print)
ISSN 2500-3194 (Online)