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Significance of detecting antiphospholipid antibodies and genetic mutations of hemostasis for in vitro fertilization

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A case of pregravid preparation is described for an in vitro fertilization (IVF) attempt in a woman after four previous IVF failures. Considering her personal and family aggravated medical history, including the family anamnesis, the patient underwent a hemostasis examination including a test for genetic mutations. A high titer of antiphospholipid antibodies of various types and multigene mutations associated with thrombophilia were found. For the treatment of acquired and inherited thrombophilia, vitamin-antioxidant and intravenous immunoglobulin therapy was initiated as well as a course of hirudotherapy. After starting of pregnancy throughout the gestation period, anticoagulant therapy by low molecular weight heparins, antiplatelet, and antioxidant therapy was carried out; in parallel, D-dimer, thrombin-antithrombin and platelet aggregation markers of thrombophilia were monitored. Pregnancy successfully ended by childbirth at 39 weeks.

About the Author

V. I. Linnikov
Saint Paul German Medical and Diagnostic Center

Valery I. Linnikov – MD, PhD, Professor

68/2 Novoselskogo St., Odessa 65023


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For citation:

Linnikov V.I. Significance of detecting antiphospholipid antibodies and genetic mutations of hemostasis for in vitro fertilization. Obstetrics, Gynecology and Reproduction. 2019;13(3):240-244. (In Russ.)

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ISSN 2313-7347 (Print)
ISSN 2500-3194 (Online)