Систематический анализ исследований по D-маннозе и перспективы ее применения при рецидивирующих инфекциях мочеполовых путей у женщин репродуктивного возраста

Цистит и другие инфекции мочеполовых путей (ИМП) у женщин репродуктивного возраста могут приводить к бесплодию, существенно осложняют течение беременности и вызывают многочисленные патологии плода. Антибиотикотерапия во время беременности – крайняя мера, поскольку сопряжена с высоким риском пороков развития плода. Эффективным и безопасным направлением терапии цистита и других ИМП, особенно во время беременности, является использование D-маннозы. Систематический анализ 32111 исследований указал на важность D-маннозы для гликозилирования белков протеома человека, поддержки функций иммунной, сердечно-сосудистой, мочевыводящей и других систем. Блокируя взаимодействие бактериальных фимбрий с эндотелием, D-манноза предотвращает адсорбцию различных бактерий (уропатогенных штаммов Escherichia coli, Pseudomonas aeruginosa, шигелл, лейшманий, микобактерий и др.) на поверхности тканей, что способствует профилактике рецидивирующих ИМП. Клинические исследования подтвердили высокую эффективность и безопасность использования D-маннозы и веществ-синергистов (антоцианины клюквы и др.) для терапии цистита и других ИМП.

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