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Therapeutic significance of vitamin D and calcium in reducing the risk of preeclampsia

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Aim: to study the possibility of reducing the incidence of preeclampsia (PE) by giving vitamin D and calcium (Ca) to pregnant women with a high PE risk starting from the second trimester of pregnancy.

Materials and methods. A total of 101 patients from the PE high risk group were examined on weeks 14–16 of pregnancy followed by treatment with vitamin D and Ca; then, the course of pregnancy and labor was analyzed. Serum 25-hydroxycholecalciferol, vitamin D binding protein, endothelin 1-38, and ionized Ca were determined using enzyme immunoassays.

Results. In the examined women at high risk of PE, severe serum deficiency of vitamin D and Ca was detected. In patients treated with vitamin D and Ca, a two-fold decrease in the incidence of PE, a three-fold decrease in the incidence of intrauterine growth retardation syndrome, and a decrease in the number of urgent surgery-assisted deliveries were found.

Conclusion. Therapy with vitamin D and Ca from the second trimester of pregnancy increases the availability of vitamin D, leads to a more favorable course of pregnancy, and prevents the development of severe forms and early onset of PE in patients at high risk.

About the Authors

E. N. Vasilyeva
Chuvash State University named after I.N. Ulyanov
Russian Federation
Elvira N. Vasilyeva – PhD, Associate Professor, Department of Obstetrics and Gynecology

L. I. Maltseva
Kazan State Medical Academy – Branch Campus of Russian Medical Academy of Continuous Professional Education, Health Ministry of Russian Federation
Russian Federation
Larisa I. Maltseva – MD, PhD, Professor, Department of Obstetrics and Gynecology

T. G. Denisova
Chuvash State University named after I.N. Ulyanov; Postgraduate Doctors’ Training Institute, Health Ministry of the Chuvash Republic
Russian Federation

Tamara G. Denisova – MD, PhD, Professor, Department of Obstetrics and Gynecology

Vice-Rector for Research and Informatics

L. I. Gerasimova
Postgraduate Doctors’ Training Institute, Health Ministry of the Chuvash Republic
Russian Federation
Ludmila I. Gerasimova – MD, PhD, Professor, Head of Department of Public Health and Healthcare


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For citation:

Vasilyeva E.N., Maltseva L.I., Denisova T.G., Gerasimova L.I. Therapeutic significance of vitamin D and calcium in reducing the risk of preeclampsia. Obstetrics, Gynecology and Reproduction. 2019;13(2):103-110.

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