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The role of thrombophilia in the premature detachment of a normally located placenta

https://doi.org/10.17749/2313-7347.2019.13.1.029-034

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Abstract

Aim: to study the association between hereditary/acquired thrombophilia and premature detachment of normally located placenta. Materials and methods. The participating women were divided into 2 groups: the main group (n = 38) and the control group (n = 43). The main group included women, whose pregnancy or delivery was complicated by premature detachment of normally located placenta. The control group included women without previous obstetric or thrombotic complications, who gave birth to full-term live babies with an Apgar score of 8-10. The key coagulogram parameters, the presence of hyperhomocysteinemia, antiphospholipide syndrome, and polymorphisms of the hemostasis genes (by real-time polymerase chain reaction) were determined. Results. A statistically significant increase in the concentration of fibrinogen and D-dimer was found in patients of the main group. In addition, allele A of the G1691A polymorphic locus of the factor V gene and allele 4G of the 5G/4G 675 polymorphic locus of the PAI-1 gene are risk factors of placental detachment development. Conclusion. Hereditary and acquired thrombophilia are significant factors in the development of premature detachment of the normally located placenta.

About the Authors

N. M. Pasman
National Research Novosibirsk State University; Professor Pasman clinic
Russian Federation

Natalya M. Pasman - MD, PhD, Professor, Obstetrician-gynecologist, Head of the Department of Obstetrics and Gynecology, NNRSU; Director of «Professor Pasman clinic» LLC. 

2 Pirogova St., Novosibirsk 630090; 1/1 Dzerzhinsky Avenue, Novosibirsk 630112.

Tel.: +7(913)9162591.



O. V. Chumanova
National Research Novosibirsk State University
Russian Federation

Olga V. Chumanova - Medical Resident, NNRSU.

2 Pirogova St., Novosibirsk 630090.

Tel.: +7(951)3642757.



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For citation:


Pasman N.M., Chumanova O.V. The role of thrombophilia in the premature detachment of a normally located placenta. Obstetrics, Gynecology and Reproduction. 2019;13(1):29-34. (In Russ.) https://doi.org/10.17749/2313-7347.2019.13.1.029-034

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ISSN 2313-7347 (Print)
ISSN 2500-3194 (Online)