Clinical and hemostatic characteristics of women with menopausal syndrome receiving the «Extra youth» dietary supplement
Abstract
Aim: to study the clinical and hemostatic changes in women with menopausal syndrome (MS), receiving the dietary supplement Doctor sea «Extra youth» (EY), containing hydrolyzed caviar of sea urchins, calcium alginate and rosehip extract. Materials and methods. The study involved 60 women with MS aged 45–55 years. The patients were divided into 2 groups: the main group consisted of 30 women who received the EY supplement, the comparison group – 30 women who received no EY. During the study, women in the main group received two EY capsules twice a day for 1 month. The severity of the menopausal symptoms and the characteristics of hemostasis before and after taking the EY were evaluated. Results. After 1 month on the EY, the menopausal symptoms (hot flashes, sweating, heart palpitations, nervousness, fatigue) alleviated, general well-being improved, and a better hemostatic performance occurred (chronometric and structural hypercoagulation, a decrease in platelet aggregation and the D-dimer level). Conclusion. The dietary supplement EY can be recommended for use in general clinical practice as a means to improve the well-being of women in pre- and post-menopausal period and also to prevent thrombotic complications.
About the Authors
J. Kh. Khizroeva
I.M. Sechenov First Moscow State Medical Universit
Russian Federation
Russian Federation
MD, PhD, Professor, Department of Obstetrics and Gynecology, Faculty of Preventive Medicine
62 St. Zemlyanoi Val, Moscow 109004, Russia
V. O. Bitsadze
I.M. Sechenov First Moscow State Medical Universit
Russian Federation
Russian Federation
MD, PhD, Professor, Department of Obstetrics and Gynecology, Faculty of Preventive Medicine
62 St. Zemlyanoi Val, Moscow 109004, Russia
N. A. Makatsariya
I.M. Sechenov First Moscow State Medical Universit
Russian Federation
Russian Federation
PhD, Assistant, Department of Obstetrics and Gynecology № 2,
62 St. Zemlyanoi Val, Moscow 109004, Russia
E. S. Egorova
I.M. Sechenov First Moscow State Medical Universit
Russian Federation
Russian Federation
PhD, Associate Professor, Department of Obstetrics and Gynecology, Faculty of Medical and Preventive Medicine
62 St. Zemlyanoi Val, Moscow 109004, Russia
N. N. Babaeva
I.M. Sechenov First Moscow State Medical Universit
Russian Federation
Russian Federation
Obstetrician-Gynecologist, Postgraduate Student, Department of Obstetrics and Gynecology, Faculty of Clinical and Preventive Medicine
62 St. Zemlyanoi Val, Moscow 109004, Russia
References
1. Kovalev N.N., Kryzhanovsky S.P., Kuznetsova T.A., Kostetsky E.Y., Besednova N.N. Sea urchins: biomedical aspects of practical application. [Morskie ezhi: biomedicinskie aspekty prakticheskogo primeneniya]. Vladivostok: Dal'nauka, 2016. 128 p (in Russ.).
2. Ebert T.A., Southon J.R. Red sea urchins (Strongylocentrotus franciscanus) can live over 100 years. Fish Bull. 2003;101(4):915–22.
3. Yuriev M.I., Viktorovskaya G.I., Akulin V.N. Lipids composition of the sea urchin gonad Strongylocentrotus pallidus from the Sea of Japan. [Sostav lipidov gonad morskogo ezha Strongylocentrotus pallidus iz Yaponskogo morya]. Izvestiya TINRO. 2000;127(1–2):483–9 (in Russ.).
4. Mishenko N.P., Fedoreev S.A., Gusev E.I. The influennce of histochrome on the dynamics of neurological disorders and MRI pictures in experimental hemorrhagic stroke. [Vliyanie gistohroma na dinamiku nevrologicheskih narushenij i MRT-kartiny pri eksperimental'nom gemorragicheskom insul'te]. Zhurnal nevrologii i psihoterapii. Insul't. 2005;(15):61–6 (in Russ.).
5. Menshikova E.B., Lankin V.Z., Zenkov N.K. et al. Oxidative stress. Prooxidants and antioxidants. [Okislitel'nyj stresc. Prooksidanty i antioksidanty]. Moskva: Slovo, 2006. 556 p (in Russ.).
6. Lebedev A.V., Levitskaya E.L., Tikhonova E.V. Antioxidant properties, auto-oxidation and mutagenic activity of echinochrome A in comparison with its structural analogues. [Antioksidantnye svojstva, avtookislenie i mutagennaya aktivnost' ehinohroma A v sravnenii s ego strukturnymi analogami]. Biohimiya. 2001;66:885–93 (in Russ.).
7. Makarova N.V., Zyuzina A.V. Investigation of antioxidant activity of juice production semis with DPPH method. [Issledovanie antioksidantnoj aktivnosti po metodu DPPH polufabrikatov proizvodstva sokov]. Tekhnika i tekhnologiya pishchevyh proizvodstv. 2011;(3) 14–9 (in Russ.).
8. Artyukov A.A. Development of biotechnological bases for the production of some biologically active substances from oceanic raw materials. [Razrabotka biotekhnologicheskih osnov polucheniya nekotoryh biologicheski aktivnyh veshchestv iz okeanicheskogo syr'ya]. Avtoref. dis. dokt. biol. nauk. Vladivostok, 2012. 54 p (in Russ.).
9. Kuwahara R., Yuki T., Murata H., Tanaka R., Hama Y. Antioxidant property of polyhydroxylated naphthoquinone pigments from shells of purple sea urchin Anthocidaris crassispina. LWT–Food Sci Technol. 2009;42(7):1296–300.
10. Krivoshapko O.N. Experimental studies of the biological activity of various compounds from marine hydrobionts. [Eksperimental'nye issledovaniya biologicheskoj aktivnosti razlichnyh soedinenij iz morskih gidrobiontov]. Avtoref. dis. kand. biol. nauk. Vladivostok, 2012. 26 p (in Russ.).
11. Yurieva M.I., Lisakovskaya O.V., Akulin V.N. Sea urchin gonads are a source for creating drugs that stimulate sexual behavior. [Gonady morskih ezhej – istochnik dlya sozdaniya preparatov, stimuliruyushchih polovoe povedenie]. Biologiya morya. 2003;29(3):213–6 (in Russ.).
For citation:
Khizroeva J.Kh., Bitsadze V.O., Makatsariya N.A., Egorova E.S., Babaeva N.N. Clinical and hemostatic characteristics of women with menopausal syndrome receiving the «Extra youth» dietary supplement. Obstetrics, Gynecology and Reproduction. 2018;12(4):85-91. (In Russ.)
Views: 229
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Email this article 
