Microflora of the urinary tract and intestines in patients without and with chronic endometritis

Abstract

Inflammation is considered a typical response to tissue injury. At present, we see an increasing number of patients with chronic inflammation, where the damaging factor is unclear. Specifically, the pathogenetic factors of chronic endometritis (СЕ) need to be studied both in the gynecological and somatic aspects of the disease, including the functional state of other organs and systems. Aim: to analyse the microflora of the urinary tract and the intestines in patients with СЕ and various somatic conditions. Materials and methods. The intestinal and urinary tract microflora were assayed using microscopic, microbiological and molecular biological methods. To prevent false positive results and minimize sample contamination, we used our own modification. Results. The intestinal microbiota in patients with СЕ significantly differed from that in relatively healthy controls. We found a relationship between the abnormal colon microflora and the diseases of the upper and lower gastrointestinal tract, in particular, chronic cholecystitis, gastritis, and functional disorders of the intestine. These findings may become important for compbined therapy. Conclusion. The results indicate the need to individualize the pharmacol therapeutic treatment of patients with СЕ, especially those with impaired fertility. The treatment strategy should be based on minimizing the adverse drug effects, and considering the concomitant diseases.