The relationships between pregnancy-associated protein A levels, placental localization and fetal birth weight
https://doi.org/10.17749/2313-7347.2018.12.4.015-020
Abstract
Aim. This study was designed to determine the relationship between pregnancy-associated protein A (PAPP-A), placenta localization and fetal birth weight (FBW). Materials and methods. First trimester PAPP-A levels, second trimester placental localization and birth weights of 1145 infants were obtained through a retrospective review of the patient follow up charts in Koru Hospital. Serum PAPP-A levels were recorded as the multiple of median (MоM) values, the FBW values of infants were recorded in grams, and the placental localization was recorded under seven different pre-defined categories: 1. placenta anterior; 2. placenta posterior; 3. placenta fundal; 4. placenta fundal-anterior; 5. placenta fundal-posterior; 6. placenta lateral-right; 7. placenta lateral-left. The data were analyzed using the Statistical Package for Social Sciences (SPSS) program (SPSS Inc., Chicago, IL, USA). Results. There was no significant difference between the FBW and PAPP-A levels. The comparison of seven placental localizations shows that the anterior and posterior localizations have an impact on FBW of the infants. Conclusion. The FBW was highest in the cases where the placenta was located in the corpus uteri. We believe this finding is consistent with the fact that the corpus uteri receives the largest blood supply.
About the Authors
A. E. Güler
Lokman Hospital, Fethiye, Turkey
Turkey
MD, Gynecology and Obstetrics Department
Turkey
MD, Gynecology and Obstetrics Department
M. Atasever
Giresun University, Giresun
Turkey
Associate Professor, Faculty of Medicine, Department of Obstetrics and Gynecology
Turkey
Associate Professor, Faculty of Medicine, Department of Obstetrics and Gynecology
U. Fidan
University of Health Sciences; Keçiören-Ankara, 06010 Turkey
Turkey
Associate Professor, Gülhane Medical Faculty, Department of Obstetrics and Gynecology
Turkey
Associate Professor, Gülhane Medical Faculty, Department of Obstetrics and Gynecology
E. Artürk
Hospital Gynecology and Obstetrics, Sisli, İstanbul
Turkey
MD
Turkey
MD
M. F. Kinci
University of Health Sciences; Keçiören-Ankara, 06010 Turkey
Turkey
MD, Gülhane Medical Faculty, Department of Obstetrics and Gynecology
Turkey
MD, Gülhane Medical Faculty, Department of Obstetrics and Gynecology
S. Bodur
University of Health Sciences; Keçiören-Ankara, 06010 Turkey
Turkey
MD, Associate Professor, Gülhane Medical Faculty, Department of Obstetrics and Gynecology
Turkey
MD, Associate Professor, Gülhane Medical Faculty, Department of Obstetrics and Gynecology
References
1. Fidan U., Ulubay M., Bodur S. et al. The effect of anatomical placental location on the third stage of labor. Clinical Anatomy. 2017;3(4):508–11.
2. Sun I.Y., Overgaard M.T., Oxvig C., Giudice L.C. Pregnancy associated plasma protein A proteolytic activity is associated with the human placental trophoblast cell membrane. J Clin Endocrinol Metab. 2002;87:5235–40.
3. Giudice L.C., Conover C.A., Bale L. et al. Identification and regulation of the IGFBP-4 protease and its physiological inhibitor in human trophoblasts and endometrial stroma: evidence for paracrine regulation of IGF II bioavailability in the placental bed during human implantation. J Clin Endocrinol Metab. 2002;87:2359–66.
4. Kniss D.A., Shubert P.J., Zimmerman P.D. et al. Insulin-like growth factors. Their regulation of glucose and amino acid transport in placental trophoblasts isolated from first trimester chorionic villi. J Reprod Med. 1994;39(4):249–56.
5. Çoskun B., Kokanali D., Çoskun B. et al. Association between second trimester maternal serum markers and birthweight. J Turk Ger Gynecol Assoc. 2016;17:S313.
6. Obstetrics: normal and problem pregnancies. Eds. S.G. Gabbe, J.R. Niebyl, J.L. Simpson. 5th edition. Churchill Livingstone, 2007. 1416 p.
7. Gonser M., Tillack N., Pfeiffer K.H., Mielke G. Placental location and incidence of preeclampsia. Ultraschall Med. 1996;17(5):236–8.
8. Newton E.R., Barass V., Cetrulo C.L. The epidemiology and clinical history of asymptomatic midtrimester placenta previa. Am J Obstet Gynecol. 1984;148(6):743–8.
9. Canini S., Prefumo F., Pastorino D. et al. Association between birth weight and first-trimester free β-human chorionic gonadotropin and pregnancy-associated plasma protein A. Fertil Steril. 2008:89(1):174–8.
10. Leung T.Y., Chan L.W., Leung T.N. et al. First-trimester maternal serum levels of placental hormones are independent predictors of second-trimester fetal growth parameters. Ultrasound Obstet Gynecol. 2006;27(2):156–61.
11. Devarajan K., Kives S., Ray J.G. Placental location and newborn weight. J Obstet Gynaecol Can. 2012;34(4):325–9.
12. Torricelli M., Vannuccini S., Moncini I. et al. Anterior placental location influences onset and progress of labor and postpartum outcome. Placenta. 2015;36(4):463–6.
13. Osmundson S.S., Wong A.E., Gerber S.E. Second-trimester placental location and postpartum hemorrhage. J Ultrasound Med. 2013;32(4):631–6.
14. Magann E.F., Doherty D.A., Turner K. et al. Second trimester placental location as a predictor of an adverse pregnancy outcome. J Perinatol. 2007;27(1):9–14.
15. Kalem M.N., Yildirim S., Onaran Y. et al. Low birth weight and perinatal risk factors. Yeni Tıp Dergisi. 2015;32:152–6.
Review
For citations:
Güler A.E., Atasever M., Fidan U., Artürk E., Kinci M.F., Bodur S. The relationships between pregnancy-associated protein A levels, placental localization and fetal birth weight. Obstetrics, Gynecology and Reproduction. 2018;12(4):15-20. https://doi.org/10.17749/2313-7347.2018.12.4.015-020
Views:
921
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Email this article 
