Preview

Obstetrics, Gynecology and Reproduction

Advanced search

Efficacy of dequalinium chloride vaginal tablets in treatment of bacterial vaginosis

https://doi.org/10.17749/2313-7347.2018.12.3.029-034

Full Text:

Abstract

Aim: to evaluate the efficacy and duration of the therapeutic effect of dequalinium chloride (in comparison with clindamycin) in treatment of vaginal dysbiosis. Materials and methods. A total of 73 fertile-aged women (18-35 years old) with abnormal vaginal microbiota were examined. The patients were randomized into two groups: Group 1 (main) included 37 women receiving dequalinium chloride; Group 2 (control) included 36 women under clindamycin therapy. The efficacy was assessed by analyzing patients’ complaints, by gynecological examinations, pH values of the vaginal fluid, the Amsel criteria, the microscopy results and the polymerase chain reaction (PCR). Results. Before the treatment, the Amsel criteria were positive in 36 patients (97.29%) in the main group and in 31 patients (93.93%) in the control group; all patients showed an increase in the pH values of the vaginal fluid by more than 4.5 units. The state of vaginal microbiocenosis as evaluated with RT-PCR diagnostics (Femoflor 16 analysis) identified a variety of gram-positive and gram-negative bacteria with a marked decrease in the number of Lactobacilli. During the treatment period, there were no complaints of adverse events; pH values were normal in all patients; the Femoflor 16 analysis showed a significant decrease in the amounts of pathogenic microorganisms. As assessed in 1 month after the treatment, the therapeutic effect persisted. Conclusion. The dequalinium chloride has antibacterial effect on bacterial vaginosis. The results of the study showed that dequalinium chloride had the efficacy comparable with that of clindamycin.

About the Authors

A. B. Khuraseva
Kursk State Medical University, Health Ministry of Russian Federation
Russian Federation
Khuraseva Anna Borisovna – MD, Professor, Department of Obstetrics and Gynecology, Faculty of Postgraduate Education, KSMU HM of RF;
3, ul. Karla Marksa, Kursk, 305041, Russia


T. V. Reminnaya
Kursk State Medical University, Health Ministry of Russian Federation
Russian Federation
Reminnaya Tatyana Viktorovna – Postgraduate Student, Department of Obstetrics and Gynecology, Faculty of Postgraduate Education, KSMU HM of RF;
3, ul. Karla Marksa, Kursk, 305041, Russia


References

1. Menard J.P., Bretelle F. How can the treatment of bacterial vaginosis be improved to reduce the rust of preterm delivery? Women”s Health. 2012; 8: 5: 491-3.

2. Manukhin I.B. Treat it immediately! [Lechite eto nemedlenno!]. StatusPraesens. 2013; 2: 46-50 (in Russian).

3. Ya W., Reifer C., Miller L.E. Efficacy of vaginal probiotic capsules for recurrent bacterial vaginosis: a double-blind, randomized, placebocontrolled study. Am J Obstet Gynecol. 2010; 203 (2): 120. е121-е126.

4. Obstetrics. Clinical lectures. [Akusherstvo. Klinicheskie lekcii (Pod red. O.V. Makarova)]. Moskva: GEOTAR-Media. 2007: 640 s (in Russian).

5. Diseases of the cervix, vagina and vulva. Clinical lectures. [Zabolevaniya shejki matki, vlagalishcha i vul'vy. Klinicheskie lekcii (Pod red. V.N. Prilepskoj)]. Moskva: MEDpress-inform. 2005: 432 s (in Russian).

6. Safonova O.P., Zakaryan L.M., Kalutskiy P.V., Huraseva A.B. Features of vaginal biocenosis in women using hormonal contraception. 66 Interuniversity research and practice conference of students and young scientists «Actual problems of medicine and pharmacy»: abstracts. [Osobennosti vlagalishchnogo biocenoza u zhenshchin, ispol'zuyushchih gormonal'nuyu kontracepciyu. 66 mezhvuzovskaya nauchno-prakticheskaya konferenciya studentov i molodyh uchenyh «Aktual'nye problemy mediciny i farmacii»: tezisy dokladov]. Kursk: Izdatel'stvo KGMU. 2001: 299-300. URL: https://kurskmed.com/ upload/departments/library/files/bibliography/ Sborniki_KGMU-2000-2015.pdf (in Russian).

7. Kudryavtseva L.V. Bacterial vaginosis (guide for doctors). [Bakterial'nyj vaginoz (posobie dlya vrachej)]. Moskva. 2005: 48 s (in Russian).

8. Della Casa V., Noll H., Gonser S. et al. Antimicrobial activity of dequalinium chloride against leading germs of vaginal infection. Arzneimittelforschung. 2002; 52: 699-705.

9. Aksenova O.A. Modern aspects of the clinic, diagnosis and treatment of bacterial vaginosis in women of reproductive age. [Sovremennye aspekty kliniki, diagnostiki i lecheniya bakterial'nogo vaginoza u zhenshchin reproduktivnogo vozrasta]. Avtoref. dis. kand. med. nauk. Moskva. 2005: 20 s (in Russian).

10. Bacterial vaginosis. [Bakterial'nyj vaginoz (Pod red. E.F. Kira)]. SPb.: Neva-Lyuks. 2001: 364 s (in Russian).

11. Dmitriev G.A., Glazko I.I. Bacterial vaginosis. [Bakterial'nyj vaginoz]. Moskva: BINOM. 2008: 192 s (in Russian).

12. Krasnopolskiy V.I., Serova OF.F., Tumanova V.A. et al. The influence of infections on the reproductive system of women. [Vliyanie infekcij na reproduktivnuyu sistemu zhenshchin]. Rossijskij vestnik akushera-ginekologa. 2004; 4: 5: 26-9 (in Russian).


For citation:


Khuraseva A.B., Reminnaya T.V. Efficacy of dequalinium chloride vaginal tablets in treatment of bacterial vaginosis. Obstetrics, Gynecology and Reproduction. 2018;12(3):29-34. (In Russ.) https://doi.org/10.17749/2313-7347.2018.12.3.029-034

Views: 50


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 2313-7347 (Print)
ISSN 2500-3194 (Online)