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ASSOCIATION BETWEEN POLYMORPHIC GENES OF FOLATE METABOLISM AND EARLY PREGNANCY LOSSES

https://doi.org/10.17749/2313-7347.2018.12.1.042-052

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Abstract

Aim: to analyze the polymorphic genes of folate metabolism in women with history of non-developing pregnancy and in their embryos/fetuses in order to relate the genetic polymorphism with the risk of early pregnancy loss.

Materials and methods. The main group consisted of 117 women with non-developing 1st trimester pregnancy; the comparison group included 117 women with no history of miscarriage, with physiological 1st trimester pregnancy and a normal fetal karyotype. By polymerase chain reaction in real time using DT-96 machine («DNA-technology», Russia) all women and embryos were analyzed for the following polymorphic variants: MTHFR 677 C>T, MTHFR 1298 A>C, MTRR 66 A>G, MTR 2756 A>G.

Results. The women with non-developing pregnancy and chromosomal abnormalities of the fetus had a significantly higher occurrence of the MTR 2756G allele in comparison with women with non-developing pregnancy and a normal karyotype of the fetus.

Conclusion. The 2756G allele of the polymorphic MTR 2756 A>G gene in women with non-developing pregnancy is associated with a chromosomal imbalance of their fetuses.

About the Authors

T. B. Tretyakova
Urals Scientific Research Institute for Maternal and Child Care, Health Ministry of Russian Federation
Russian Federation

Tretyakova Tatyana Borisovna – PhD, Associate Professor, Senior Researcher, Head of Laboratory of Genetics.

1, ul. Repina, Yekaterinburg, 620028, +7(912)2467716



N. S. Demchenko
Urals Scientific Research Institute for Maternal and Child Care, Health Ministry of Russian Federation
Russian Federation

Demchenko Nadezhda Sergeevna – PhD, Geneticist, Laboratory of Genetics.

1, ul. Repina, Yekaterinburg, 620028, +7(904)5405056



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For citation:


Tretyakova T.B., Demchenko N.S. ASSOCIATION BETWEEN POLYMORPHIC GENES OF FOLATE METABOLISM AND EARLY PREGNANCY LOSSES. Obstetrics, Gynecology and Reproduction. 2018;12(1):42-52. (In Russ.) https://doi.org/10.17749/2313-7347.2018.12.1.042-052

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ISSN 2313-7347 (Print)
ISSN 2500-3194 (Online)