ENDOTHELIAL SYSTEM OF MOTHER AND FETUS DURING THE FIRST TRIMESTER OF PREGNANCY
Abstract
Aim: to study the endothelial system in women with undeveloped pregnancy and their fetuses.
Materials and methods. The study included 180 first trimester pregnant women. The main group was composed of 90 women, whom a 7-10 week miscarriage was diagnosed followed by an instrumental abortion. The control group included 90 somatic healthy pregnant women, who chose to interrupt their pregnancy by an instrumental abortion. To characterize the endothelium system, we determined the number of desquamated endothelial cells together with cytometric evaluation of cell diameter, perimeter, area, shape, and polarization. Following the instrumental abortion, morphology of the fetal chorion was studied in women of both groups. Light microscopy was used to assess the fetal blood vessels and their differentiation. By means of computed cytomorphometry we determined the primary vessel wall thickness, lumen diameter and its area, as well as the Kernogan index.
Results. The cytometric analysis of desquamated endotheliocytes in pregnant women and that of fetal chorion blood vessels showed identical morphological changes in the endothelial systems of all examined women with pathological pregnancy.
Conclusion. The endothelial dysfunction found in the first trimester pregnant women is accompanied with changes in the endothelium of the fetal chorion, which can lead to pregnancy failure.
About the Authors
A. V. Mironov
Moscow State University of Medicine and Dentistry named after A.I. Evdokimov, Health Ministry of Russian Federation; City Clinical Hospital № 13, Moscow City Health Department
Russian Federation
Russian Federation
Mironov Alexey Valentinovich – PhD, Assistant, Department of Obstetrics and Gynecology, Faculty of Dentistry MSUMD n.a. A.I. Evdokimov HM of RF. Obstetrician-gynecologist, CCH № 13 Moscow City Health Department.
20, st. 1, ul. Delegatskaya, Moscow, 127473; 1/1, Velozavodskaya ul., Moscow, 115280, +7(916)6374374
A. M. Torchinov
Moscow State University of Medicine and Dentistry named after A.I. Evdokimov, Health Ministry of Russian Federation
Russian Federation
Russian Federation
Torchinov Amirkhan Mikhaylovich – MD, Professor, Head of Department of Obstetrics and Gynecology, Faculty of Dentistry.
20, st. 1, ul. Delegatskaya, Moscow, 127473
M. M. Umakhanova
Moscow State University of Medicine and Dentistry named after A.I. Evdokimov, Health Ministry of Russian Federation
Russian Federation
Russian Federation
Umakhanova Madina Musaevna – MD, Professor, Department of Obstetrics and Gynecology, Faculty of Dentistry.
20, st. 1, ul. Delegatskaya, Moscow, 127473
O. V. Galachiev
Moscow State University of Medicine and Dentistry named after A.I. Evdokimov, Health Ministry of Russian Federation
Russian Federation
Russian Federation
Galachiev Oleg Viktorovich – Senior Assistant, Department of Obstetrics and Gynecology, Faculty of Dentistry.
20, st. 1, ul. Delegatskaya, Moscow, 127473
References
1. Sidorova I.S., Kiryushchenkov A.P., Vartanova A.O. Immunogenetic methods as criteria for predicting pregnancy and childbirth outcomes in patients with acute gestational pyelonephritis [Immunogeneticheskie metody kak kriterii prognozirovaniya iskhodov beremennosti i rodov u pacientok s ostrym gestacionnym pielonefritom]. Akusherstvo i ginekologiya. 2010; 4: 23-7 (in Russian).
2. Sidorova I.S., Nikitina N.A. Features of the pathogenesis of endotheliosis in preeclampsia [Osobennosti patogeneza endotelioza pripreehklampsii]. Akusherstvo i ginekologiya. 2015; 1: 72-8 (in Russian).
3. Jim B., Sharma S., Kebede T., Acharya A. Hypertension in pregnancy: a comprehensive update. Cardiol Rev. 2010; 18 (4): 178-89.
4. Causes and differentiated treatment of early miscarriage: a guide for doctors [Prichiny i differencirovannoe lechenie rannego nevynashivaniya beremennosti: rukovodstvo dlya vrachej (Pod red. A.P. Milovanova, O.F. Serovoj)]. Moskva: Studiya MDV. 2011: 216 s (in Russian).
5. Nevzorova I.A., Pashov A.I., Sturov V.G. Miscarriage and endothelial dysfunction [Nevynashivanie beremennosti i endotelial'naya disfunkciya]. II Mezhdunarodnyj kongress «Novye tekhnologii v akusherstve, ginekologii, perinatologii i reproduktivnoj medicine»: tezisy dokladov. Novosibirsk. 2013: 9-10 (in Russian).
6. Ambulatory-polyclinic care in obstetrics and gynecology [Ambulatorno-poliklinicheskaya pomoshch' v akusherstve i ginekologii (Pod red. I.S. Sidorovoj, T.V. Ovsyannikovoj, I.O. Makarova)]. Moskva: MEDpress-inform. 2009: 720 s (in Russian).
7. Brewer C.J., Balen A.H. The adverse effects of obesity on conception and implantation. Reproduction. 2010; 140 (3): 347-64.
8. Rachkova O.V., Kuznetsov P.A., Peretyatko L.P., Kruglova L.V. Pathomorphological differential diagnosis of the etiology of spontaneous miscarriages [Patomorfologicheskaya differencial'naya diagnostika etiologii samoproizvol'nyh vykidyshej. Problemy reprodukcii (special'nyj vypusk)]. VI Mezhdunarodnyj kongress po reproduktivnoj medicine: tezisy dokladov. Moskva. 2012: 37 (in Russian).
9. Trokhimovich O.V. Immunohistochemical features of the chorion and endometrium in women with early pregnancy loss [Immunogistohimicheskie osobennosti horiona i endometriya u zhenshchin s rannimi poteryami beremennosti]. Morphologia. 2015; 9 (1): 58-64 (in Russian).
10. Sidelnikova V.M., Sukhikh G.T. Unintention of pregnancy: a guide for practicing doctors [Nevynashivanie beremennosti: rukovodstvo dlya praktikuyushchih vrachej]. Moskva: MIA. 2010: 986 s (in Russian).
11. Bashiri A., Jordana M.F., Moshe M. Oligohydramnios associated with a long umbilical cord. IJCRI. 2011; 2 (1): 15-7.
12. Sadekova O.N., Knyazeva I.P., Yarovaya E.B. et al. The role of systemic disorders in the formation of gestational complications and their genetic component [Rol' sistemnyh narushenij v formirovanii gestacionnyh oslozhnenij i ih geneticheskaya sostavlyayushchaya]. Akusherstvo i ginekologiya. 2012; 4/2: 21-8 (in Russian).
13. Hladovec J., Prerovsky I., Stanek V., Fabian J. Circulating endothelial cells in acute myocardial infarction and angina pectoris. Klin Wochenschr. 1978; 56 (20): 1033-6.
14. Li C., Xu Y., Chen R., Deng C. An effective treatment for penile strangulation. Mol Med Rep. 2013; 8 (1): 201-4.
15. Feoktistova V.S., Vavilova T.V., Sirotkina O.V. et al. A new approach to the evaluation of endothelial dysfunction: the determination of the number of circulating endothelial cells by flow cytometry [Novyj podhod k ocenke disfunkcii endoteliya: opredelenie kolichestva cirkuliruyushchih endotelial'nyh kletok metodom protochnoj citometrii]. Klinicheskaya laboratornaya diagnostika. 2015; 60 (4): 23-7 (in Russian).
16. Fadini G.P. Pagano C., Baesso I. et al. Reduced endothelial progenitor cells and brachial artery flow-mediated dilation as evidence of endothelial dysfunction in ocular hypertension and primary open-angle glaucoma. Acta Ophthalmol. 2010; 88 (1): 135-41.
17. Lampka M., Grąbczewska Z., Jendryczka-Maćkiewicz E. Circulating endothelial cells in coronary artery disease. Kardiologia Polska. 2010; 68 (10): 1100-5.
Review
For citations:
Mironov A.V., Torchinov A.M., Umakhanova M.M., Galachiev O.V. ENDOTHELIAL SYSTEM OF MOTHER AND FETUS DURING THE FIRST TRIMESTER OF PREGNANCY. Obstetrics, Gynecology and Reproduction. 2018;12(1):34-41. (In Russ.) https://doi.org/10.17749/2313-7347.2018.12.1.034-041
Views: 456
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Email this article 
