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Genetic thrombophilia is a risk factor for both thromboembolic and obstetric complications. Patients with a family history of thrombotic and obstetric complications should be examined for the presence of thrombophilia. If a hemostasis problem is confirmed, antithrombotic therapy is recommended to be initiated at early stages of pregnancy. Moreover, this therapy is better to be started at the stage of preparation for pregnancy and continued throughout the pregnancy and during the postpartum period to avoid thromboembolic and obstetrical complications.

About the Authors

D. L. Kapanadze
Center of Pathology of Pregnancy and Hemostasis.
Russian Federation

Kapanadze Daredzhan Levanovna – PhD, Head of Center of Pathology of Pregnancy and Hemostasis.

ul. Uznadze, 78, Tbilisi, Georgia, 0179.  

T. A. Diakonidze
Ivane Javakhishvili Tbilisi State University.
Russian Federation

Diakonidze Tamara Avtandilovna – Postgraduate student, Department of Obstetrics and Gynecology.

ul. I. Chavchavadze, 1, Tbilisi, Georgia, 0128.  

V. B. Zubenko
Stavropol Regional Clinical Perinatal Center № 1.
Russian Federation

Zubenko Vladislav Borisovich – Head of Obstetric Department.

ul. Semashko, 3/1, Stavropol, 355029. 


1. Akinshina S.V., Makatsaria A.D., Bitsadze V.O., Andreeva M.D. Clinic, diagnosis and prevention of venous thromboembolic complications during pregnancy [Klinika, diagnostika i profilaktika venoznyh tromboembolicheskih oslozhnenij vo vremya beremennosti]. Akusherstvo, ginekologiya i reprodukciya. 2014; 8 (4): 27-36 (in Russian).

2. Nicolaides A.N., Fareed J., Kakkar A.K. et al. Prevention and treatment of venous thromboembolism – International Consensus statement. Int Angiol. 2013; 32 (2): 111-260.

3. Koniari I., Siminelakis S.N., Baikoussis N.G. et al. Antiphospholipid syndrome: its implication in cardiovascular diseases: a review. J Cardiothorac Surg. 2010; 5 (1): 101-10. DOI: 10.1186/1749-8090-5-101.

4. Brill-Edwards P., Ginsberg J.S., Gent M. et al. Safety of withholding heparin in pregnant women with a history of venous thromboembolism. Recurrence of Clot in This Pregnancy Study Group. N Engl J Med. 2000; 343 (20): 1439-44.

5. Bezgin T., Kaymaz C., Akbal O. et al. Thrombophilic Gene Mutations in Relation to Different Manifestations of Venous Thromboembolism: A Single Tertiary Center Study. Clin Appl Thromb Hemost. 2016. URL: [Assessed: 16.01.2018]. DOI: 10.1177/1076029616672585.

6. Aznar J., Vaya A., Estelles A. et al. Risk of venous thrombosis in carriers of the prothrombin G20210A variant and factor V Leiden and their interaction with oral contraceptives. Haematologica. 2000; 85 (12): 1271-6.

7. Gerhardt A., Scharf R.E., Greer I.A., Zotz R.B. Hereditary risk factors for thrombophilia and probability of venous thromboembolism during pregnancy and the puerperium. Blood. 2016; 128 (19): 2343-9. DOI: 10.1182/blood-2016-03-703728.

8. Gillis D., Wong R.C.W. Rarer clinical associations of antiphospholipid antibodies. Semin Thromb Hemost. 2012; 38 (4): 328-32.

9. Atabayeva Kh.L. Basic principles of preparation for pregnancy and its management in pregnant women with pre-eclampsia against the background of detected thrombophilia [Osnovnye principy podgotovki k beremennosti i ee vedenie u beremennyh s preeklampsiej na fone vyyavlennoj trombofilii]. Akusherstvo, ginekologiya i reprodukciya. 2016; 10 (4): 30-8 (in Russian).


For citations:

Kapanadze D.L., Diakonidze T.A., Zubenko V.B. ROLE OF GENETIC THROMBOPHILIA IN THE DEVELOPMENT OF THROMBOEMBOLIC AND OBSTETRIC COMPLICATIONS. Obstetrics, Gynecology and Reproduction. 2017;11(4):68-71. (In Russ.)

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ISSN 2313-7347 (Print)
ISSN 2500-3194 (Online)