RARE THROMBOSIS LOCALIZATION IN A CANCER PATIENT WITH COMBINED THROMBOPHILIA: A CLINICAL CASE
https://doi.org/10.17749/2313-7347.2017.11.3.088-093
Abstract
This report presents a rare case of thrombophilia – thrombosis of the ovarian vein in combination with thrombosis of the right common iliac vein. The symptoms were initially interpreted as acute appendicitis that led to the decision to perform laparoscopy. Thereafter, a different diagnosis – acute endometritis, acute salpingo-oophoritis – was proposed. As the subsequent treatment resulted in no improvement, a CT scan was performed to detect thrombi of a typical localizations and a mass in the uterus area, which turned out to be a poor-differentiated adenocarcinoma. In the patient’s medical history, multiple signs of family thrombophilia were found; further laboratory tests also pointed to the diagnosis of thrombophilia. Considering the previously performed surgery and the confirmed thrombophilia of rare localization, permanent anticoagulant therapy was recommended.
About the Authors
A. V. Vorobiev
I.M. Sechenov First Moscow State Medical University, Health Ministry of Russian Federation
Russian Federation
Russian Federation
Vorobiev Alexander Viktorovich – PhD, Associate Professor, Department of Obstetrics and Gynecology, Faculty of Preventive Medicine.
Ul. Zemlyanoi val, 62, Moscow, 109004
A. D. Makatsaria
I.M. Sechenov First Moscow State Medical University, Health Ministry of Russian Federation
Russian Federation
Russian Federation
Makatsariya Aleksander Davidovich – MD, Corresponding Member of RAS, Professor, Head of Department of Obstetrics and Gynecology, Faculty of Preventive Medicine.
Ul. Zemlyanoi val, 62, Moscow, 109004
References
1. Keeling D., Klok F.A., Le Gal G. Controversies in venous thromboembolism. 2015. Blood Rev. 2016; 30 (1): 27-33.
2. Thalin C., Blomgren B., Mobarrez F., Lundstrom A., Laska A.C., von Arbin M. et al. Trousseau's Syndrome, a Previously Unrecognized Condition in Acute Ischemic Stroke Associated With Myocardial Injury. J Investig Med High Impact Case Rep. 2014; 2 (2): 1-6.
3. Semb V.B., Tveit A. Limited malignancy screening of patients with idiopathic venous thromboembolism. Tidsskr Nor Laegeforen. 2014; 134 (4): 407-1.
4. Sebastiani G.D., Iuliano A., Cantarini L., Galeazzi M. Genetic aspects of the antiphospholipid syndrome: An update. Autoimmun Rev. 2016; 15 (5): 433-9.
5. Chen F., Wang M.J., Li J., Yan C.E., Han X.H., Wu Z.Y., Qi J. Plasma D-dimer value as a predictor of malignant lymph node involvement in operable non-small cell lung cancer. Tumour Biol. 2015; 36 (12): 9201-7.
6. Zhang M.H., Xu X.H., Wang Y., Linq Q.X., Bi Y.T., Miao X.J. et al. A prognostic biomarker for gastric cancer with lymph node metastases. Anat Rec (Hoboken).
7. Tozzoli R., D'Aurizio F., Falcomer F., Basso S.M., Lumachi F. Serum Tumor Markers in Stage I-II Breast Cancer. Med Chem. 2016; 12 (3): 285-9.
8. Martínez-Lostao L., Anel A., Pardo J. How Do Cytotoxic Lymphocytes Kill Cancer Cells? Clin Cancer Res. 2015; 21 (22): 5047-56.
9. Duffy M.J., McGowan P.M., Harbeck N., Thomssen C., Schmitt M. uPA and PAI-1 as biomarkers in breast cancer: validated for clinical use in level-of-evidence-1 studies. Breast Cancer Res. 2014; 16 (4): 428.
10. Ansari D., Ansari D., Andersson R., Andrén-Sandberg A. Pancreatic cancer and thromboembolic disease, 150 years after Trousseau. Hepatobiliary Surg Nutr. 2015; 4 (5): 325-35.
11. Couturaud F., Meyer G., Mottier D. Thrombophilia and the Risk of Recurrent Venous Thromboembolism – Reply. JAMA. 2015; 314 (18): 1976.
12. Pabinger I., Ay C., Dunkler D., Thaler J., Reitter E.M., Marosi C. et al. Factor V Leiden mutation increases the risk for venous thromboembolism in cancer patients – results from the Vienna Cancer And Thrombosis Study (CATS). J Thromb Haemost. 2015; 13 (1): 17-22.
13. Kovac M., Kovac Z., Tomasevic Z., Vucicevic S., Djordjevic V., Pruner I., Radojkovic D. Factor V Leiden mutation and high FVIII are associated with an increased risk of VTE in women with breast cancer during adjuvant tamoxifen – results from a prospective, single center, case control study. Eur J Intern Med. 2015; 26 (1): 63-7.
14. Segers O., Simioni P., Tormene D., Bulato C., Gavasso S., Rosing J., Castoldi E. Genetic modulation of the FV(Leiden)/normal FV ratio and risk of venous thrombosis in factor V Leiden heterozygotes. J Thromb Haemost. 2012; 10 (1): 73-80.
15. Cooper P.C., Rezende S.M. An overview of methods for detection of factor V Leiden and the prothrombin G20210A mutations. Int J Lab Hematol. 2007; 29 (3): 153-62.
16. White C.W., Thomason A.R., Prince V. Recurrent venous thromboembolism in a patient with heterozygous factor V Leiden mutation. Hosp Pharm. 2014; 49 (8): 748-51.
17. Zhang P., Zhang J., Sun G., Gao X., Wang H., Yan W. et al. Risk of Budd-Chiari syndrome associated with factor V Leiden and G20210A prothrombin mutation: a meta-analysis. PLoS One. 2014; 9 (4): e95719.
18. Van Cott E.M., Khor B., Zehnder J.L. Factor V Leiden. Am J Hematol. 2016; 91 (1): 46-9.
19. Naushad S.M., Reddy C.A., Kumaraswami K., Divyya S., Kotamraju S., Gottumukkala S.R., Digumarti R.R., Kutala V.K. Impact of hyperhomocysteinemia on breast cancer initiation and progression: epigenetic perspective. Cell Biochem Biophys. 2014; 68 (2): 397-406.
20. Heit J.A. Predicting the risk of venous thromboembolism recurrence. Am J Hematol. 2012; 87 (Suppl 1): S63-7.
21. Falanga A., Russo L., Milesi V. The coagulopathy of cancer. Curr Opin Hematol. 2014; 21 (5): 423-9.
22. Levi M. Cancer-related coagulopathies. Thromb Res. 2014; 133 (Suppl 2): S70-5.
23. Li N. Platelets in cancer metastasis: To help the «villain» to do evil. IntJCancer. 2016; 138 (9): 2078-87.
Review
For citations:
Vorobiev A.V., Makatsaria A.D. RARE THROMBOSIS LOCALIZATION IN A CANCER PATIENT WITH COMBINED THROMBOPHILIA: A CLINICAL CASE. Obstetrics, Gynecology and Reproduction. 2017;11(3):88-93. (In Russ.) https://doi.org/10.17749/2313-7347.2017.11.3.088-093
Views: 569
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Email this article 
