EFFECT OF ETHYLMETHYLHYDROXYPYRIDINE MALATE ON THE ABSOLUTE NUMBERS OF ERYTHROBLASTIC ISLETS IN RATS EXPOSED TO SULFUR-CONTANING GAS AT DIFFERENT STAGES OF POSTNATAL ONTOGENESIS
Abstract
Objective. To study the effect of the protective agent ethylmethylhydroxypyridine malate on the numbers of erythroblastic islets in rats exposed to sulfur-containing gases. Materials and methods. Natural sulfur-containing gas mixtures from the Astrakhan gas-condensate field were used to model the gas-polluted environment. Male rats of various ages simulated different stages of postnatal human ontogenesis. Results. The obtained results indicate that at all stages of ontogenesis ethylmethylhydroxypyridine malate protected erythroblastic islets from intoxication by gaseous sulfur pollutants and led to partial normalization of proliferation and maturation of eryth rob lasts. Conclusion. The protective action of ethylmethylhydroxypyridine malate may be used for neutralizing the biological damage caused by toxic air pollutants at different stages of ontogenesis.
About the Authors
O. A. Ovsyannikova
Astrakhan State Medical University, Health Ministry of Russian Federation
Russian Federation
Russian Federation
Ovsyannikova Olga Alexandrovna - PhD, Assistant Professor, Department of Pathological Physiology
Address: ul. Bakinskaya, 121, Astrakhan, Russia, 414000.
D. V. Karpeeva
Astrakhan State Medical University, Health Ministry of Russian Federation
Russian Federation
Russian Federation
Karpeeva Daria Vladimirovna - PhD, research assistant, Department of Pathological Physiology
Address: ul. Bakinskaya, 121, Astrakhan, Russia, 414000.
M. D. Osipenko
Astrakhan State Medical University, Health Ministry of Russian Federation
Russian Federation
Russian Federation
Osipenko Marina Dmitrievna - PhD, research assistant, Department of Pathological Physiology
Address: ul. Bakinskaya, 121, Astrakhan, Russia, 414000.
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For citation:
Ovsyannikova O.A., Karpeeva D.V., Osipenko M.D. EFFECT OF ETHYLMETHYLHYDROXYPYRIDINE MALATE ON THE ABSOLUTE NUMBERS OF ERYTHROBLASTIC ISLETS IN RATS EXPOSED TO SULFUR-CONTANING GAS AT DIFFERENT STAGES OF POSTNATAL ONTOGENESIS. Obstetrics, Gynecology and Reproduction. 2017;11(2):23-28. (In Russ.) https://doi.org/10.17749/2313-7347.2017.11.2.023-028
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