CURRENT CONCEPTS IN THE PATHOGENESIS OF PRE-ECLAMPSIA. HEPATOBILIARY SYSTEM FUNCTIONAL DISORDERS IN PREGNANT WOMEN
Abstract
Today pre-eclampsia remains one of the most urgent problems in obstetrics. This condition is associated with a high incidence of maternal and perinatal deaths, which ranges from 12.1 to 23.2%. This pathological condition occurs in 7-23% of pregnancies and it does not tend to decrease. In this review article, we present and analyze the current concepts on the etiology and pathogenesis of pre-eclampsia. The issues concerning functional disorders of the hepatobiliary system in pregnant women are also discussed.
About the Authors
V. B. Tskhai
Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky
Russian Federation
Russian Federation
MD., prof., Head of the Department of Perinatology, Obstetrics and Gynecology Medical Faculty, Krasnoyarsk State Medical University nam. prof. V.F. Voyno-Yasenetsky. Address: ul. Partizana Zheleznyaka, 1, Krasnoyarsk, Russia, 660022. Tel.: +7(495)7885840
N. M. Yametova
Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky
Russian Federation
Russian Federation
the assistant to of the Department of Perinatology, Obstetrics and Gynecology Medical Faculty, Krasnoyarsk State Medical University nam. prof. V.F. Voyno-Yasenetsky. Address: ul. Partizana Zheleznyaka, 1, Krasnoyarsk, Russia, 660022. Tel.: +7(495)7885840
M. Ya. Domracheva
Krasnoyarsk State Medical University named after Professor V.F. Voino-Yasenetsky
Russian Federation
Russian Federation
Candidates of Medical Science., associate professor of Perinatology, Obstetrics and Gynecology Medical Faculty, Krasnoyarsk State Medical University nam. prof. V.F. Voyno-Yasenetsky. Address: l. Partizana Zheleznyaka, 1, Krasnoyarsk, Russia, 660022. Tel.: +7(495)7885840
References
1. Bitsadze V.O., Makatsariya A.D., Khizroeva D.Н, Makatsriya N.A., Yashenin E.V. Thrombophilia as the most important link of the pathogenesis of pregnancy complications. Prakticheskaya meditsina. 2012; 5 (60): 22-29.
2. Kulakov V.I. Clinical guedlines. Obstetrics and gynecology [Klinicheskie rekomendatsii. Akusherstvo i ginekologiya (in Russian)]. Moscow. 2008; 560.
3. Makatsariya A.D. A new look at the causes and structure of maternal mortality. Zhurnal ROAG. 2008; 1: 3-10.
4. Saveleva G.M., Shalina R.I., Kurtser M.A., Shtabnitskiy A.M., Kurtenok N.V., Konovalova O.V. Eclampsia in modern obstetrics. Akusherstvo i ginekologiya. 2010; 6: 56-59.
5. Ghulmiyyah L., Sibai B. Maternal mortality from preeclampsia/eclampsia. Semin Perinatol. 2012; 36(1): 56-59.
6. Kulakov V.I. Clinical guedlines. Obstetrics and gynecology [Klinicheskie rekomendatsii. Akusherstvo i ginekologiya (in Russian)]. Moscow. 2005; 497.
7. Murashko L.Ye., Ilinskiy I.M., Moysyuk Ya.G. The morphology of the kidney after suffering preeclampsia. Problemy beremennosti. 2001; 4: 39-42.
8. Serov V.N., Pasman N.M., Borodin Yu.I., Burukhina A.N. Preeclampsia – a disease of adaptation [Gestoz – bolezn adaptatsii (in Russian)]. Novosibirsk. 2001; 208 s.
9. Mozgovaya E.V. Endothelial dysfunction in preeclampsia. The pathogenesis, genetic predisposition, diagnosis and prevention. Methodical recommendations. [Endotelialnaya disfunktsiya pri gestoze. Patogenez,geneticheskaya predraspolozhennost, diagnostika i profilaktika. Metodicheskie rekomendatsii. (in Russian)]. Saint-Petersburg. 2003; 32 s.
10. Jaana T.M., Heiskanen M.M., Pirskanen M.J. et al. Insertiondeletion polymorphism
11. in the gene for angiotensin-converting enzyme is associated with obstetric cholestasis but not with preeclampsia. Am J Obstet Gynecol. 2001; 185: 600-603.
12. English F.A., Kenny L.C., McCarthy F.P. Risk factors and effective management of preeclampsia. Integr Blood Press Control. 2015; 3 (8): 7-12.
13. Poon L.C., Nicolaides K.H. Early prediction of preeclampsia. Obstet Gynecol Int. 2014; 2014: 297-397.
14. Maltseva L.I., Pavlova T.V. The genetic aspects of preeclampsia. Prakticheskaya meditsina. 2011; 6(54): 7-11.
15. Pecherina V.L., Mozgovaja E.V. Prevention of late gestosis. Russkiy meditsinskiy zhurnal. 2000; 3: 52-56.
16. Saftlas A.F., Olson D.R., Franks A.L. et al. Epidemiology of preeclampsia and eclampsia. Am J Obstetr Gynecol. 1998; 163: 460-465.
17. Huang S.J., Zenclussen A.C., Chen C.P., Basar M., Yang H., Arcuri F. et al. The implication of aberrant GM-CSF expression in decidual cells in the pathogenesis of preeclampsia. Am J Pathol. 2010; 177(5): 2472-2482.
18. Williams M.A., Sanchez S.E. et al. Methylene tetrahydrofolate redyctase 677 C – T polymorphism and plasma folate in in relation to preeclampsia risk among Peruvian women. Matern Fetal Neonatal Med. 2004; 15: 337-344.
19. Ookif T.K., Akashi M. et al. Am J Reprod Immunal. 2008; 60: 75-84.
20. Perederyaeva E.B., Pshenichnikova T.B., Makatsariya A.D. The role of thrombophilia in the pathogenesis of pregnancy complications in women with metabolic syndrome. Prakticheskaya meditsina. 2013; 7 (76): 32-41.
21. Ivanets T.U., Alekseeva M.L., Loginova N.S. The placental growth factor anf fms- similar tyrosine kinase-1 as markers of preeclampsy in dynamics of pregnancy. Klinicheskaya laboratornaya diagnostika. 2013; 8: 14-17.
22. Schiessl B., Innes B.A., Bulmer J.N., Otun H.A., Chadwick T.J., Robson S.C. et al. Localization of angiogenic growth factors and their receptors in the human placental bed throughout normal human pregnancy. Placenta. 2009; 30: 79-87.
23. Steegers E.A., von Dadelszen P., Duvekot J.J, Pijnenborg R. Pre-eclampsia. Lancet. 2010; 376 (9741): 631-44.
24. Stepan H., Unversucht A., Wessel N., Faber R. Predictive value of maternal angiogenic factors in second trimester pregnancies with abnormal uterine perfusion. Hypertension. 2007; 49: 818-824.
25. Kiseleva N.I. Endothelia dysfunction in preeclampsia: pathogenesis, diagnostics, treatment. Okhrana materinstva i detstva. 2011; 1 (7): 49-56.
26. Vikhlyaeva E.M. Preclinical implications of systemic disturbances, clinical outcomes and remote consequences of a preemclampsia. Akusherstvo i ginekologiya. 2009; 1: 3-6.
27. Kayumova L.H. Hemostasis at physiological pregnancy, complicated with gestosis. Meditsinskiy almanakh. 2009; 4 (9): 64-66.
28. Kiseleva N.I., Zanko S.N., Zhukova N.P., Arestova I.M., Randarenko I.G., Mamas A.N., Shepilo T.F., Pulyarova A.A. Gestoz. Intensive therapy of medical emergencies in obstetrics and gynecology. Benefit for doctors. [Gestoz. Intensivnaya terapiya neotlozhnykh sostoyaniy v akusherstve i ginekologii. Posobie dlya vrachey (in Russian)]. Minsk. 2011; 91 s.
29. Aylamazyan E.K., Stepanova O.I., Selkov S.A. Cells of immune system of mother and trophoblast cells: constructive cooperation for the sake o achievement of the joint purpose. Vestnik RAMN. 2013; 11: 12-21.
30. Klimov V.A. The endothelium of the fetoplacental complex in physiological and pathological pregnancy. Akusherstvo i ginekologiya. 2008; 2: 7-10.
31. Kulikov A.V., Shifman Ye.M., Spirin A.V. The hepatic pathology in obstetrics. Rossiyskiy meditsinskiy zhurnal. 2014; 2: 37-44.
32. Sarakhova D.H. Features of metabolic disorders of the liver in pregnant women with preeclampsia. Diss. ... kand. med. nauk. Moscow. 2009; 132 s.
33. Makarov I.O., Borovkova E.I., Kazakov R.D. Akusherstvo, ginekologiya i reproduktsiya / Obstetrics, gynecology and reproduction. 2012; 6 (4): 18-21.
34. Ivashkin V.T., Drapkina O.M., Maev I.V., Trukhmanov A.S., Blinov D.V., Pal'gova L.K., Tsukanov V.V., Ushakova T.I. RZhGGK. 2015; 6: 31-41
35. Tsukanov V.V., Yurkina A.S., Ushakova T.A., Blinov D.V. FARMAKOEKONOMIKA. Sovremennaya farmakoekonomika i farmakoepidemiologiya / PHARMACOECONOMICS. Modern pharmacoeconomics and pharmacoepidemiology. 2016; 9 (2): 17-27. DOI:10.17749/2070-4909.2016.9.2.017-027.
36. Kalimullina D.Kh., Yurkina A.S., Ushakova T.I., Blinov D.V. FARMAKOEKONOMIKA. Sovremennaya farmakoekonomika i farmakoepidemiologiya / PHARMACOECONOMICS. Modern pharmacoeconomics and pharmacoepidemiology. 2016; 9 (4): 14-23. DOI:10.17749/2070-4909.2016.9.4.014-023.
37. Fatkullina I.B. Difficulties of differential diagnostics and therapy of HELLP- syndrome. Billyuten VSNTs SO RAMN. 2007; 5 (57): 171-172.
38. Ch'ng C.L., Morgan M., Hainsworth I., Kingham J.G. Prospective study of liver dysfunction in pregnancy in Southwest Wales. Gut. 2002; 51: 876-880.
39. Popov A.V. Causes of unsatisfactory results of surgical treatment of gallstone disease, its prevention and correction. MD diss. [Prichiny neudovletvoritel'nykh rezul'tatov khirurgicheskogo lecheniya zhelchnokamennoi bolezni, sposoby ikh profilaktiki i korrektsii. Avtoref. dis. …dokt med. Nauk (in Russian)]. Perm. 2005; 42 s.
40. Trubin E.V., Grebenkin B.E., Cheremiskin V.P., Sadykova G.K. Disturbance in hepatic blood circulayion in pregnant women with gestosis as prognostic criterion of post-natal bleeding volume. Meditsinskiy almanakh. 2009; 4 (9): 69-70.
41. Kakhramanova V.A., Torchinov A.M., Maev I.V. Functional changes of the liver in women with a history of gestosis: a clinicolaboratory substantion of choosing a method of correction. Voprosy ginekologii, aksherstva i perinatologii. 2007; 6 (4): 43-47.
42. Aylamazyan E.K., Kulakov V.I., Radzinskiy V.E., Saveleva G.M. Obstetrics: national leadership [Akusherstvo: natsionalnoe rukovodstvo (in Russian)]. Moscow. 2007; 1200 s.
43. Strizhakov A.N., Davydov A.I. Clinical lectures on obstetrics and gynecology. [Klinicheskie lektsii po akusherstvu i ginekologii (in Russian)]. Moscow. 2004; V.2; 440 s.
Review
For citations:
Tskhai V.B., Yametova N.M., Domracheva M.Y. CURRENT CONCEPTS IN THE PATHOGENESIS OF PRE-ECLAMPSIA. HEPATOBILIARY SYSTEM FUNCTIONAL DISORDERS IN PREGNANT WOMEN. Obstetrics, Gynecology and Reproduction. 2017;11(1):49-55. (In Russ.) https://doi.org/10.17749/2313-7347.2017.11.1.049-055
Views: 779
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Email this article 
