АНТИФОСФОЛИПИДНЫЙ СИНДРОМ И РАННИЕ РЕПРОДУКТИВНЫЕ ПОТЕРИ
https://doi.org/10.17749/2313-7347.2016.10.4.114-122
Аннотация
Антифосфолипидные антитела (АФА) многосторонне влияют на процессы формирования и развития трофобласта с момента установления маточно-плацентарного кровотока, когда начинается активный контакт с плазмой матери, содержащей циркулирующие АФА. Открытым и широко обсуждаемым остается вопрос о влиянии АФА на развитие более ранних репродуктивных потерь, то есть на этапе имплантации и инвазии эмбриона, что клинически может проявляться бесплодием неясной этиологии, многократными неудачами экстракорпорального оплодотворения или доклиническими потерями беременности (биохимическими беременностями). Возможными патогенетическими вариантами может быть нарушение процессов ангиогенеза в эндометрии под действием антифосфолипидных антител, повышение активности NK-клеток, усиление протромботических механизмов и десинхронизация процессов фибринолиза и фибринообразования, а также негативное влияние АФА на развитие эмбриона.
Об авторах
М. И. Кривонос
ФГБНУ «НИИ акушерства гинекологии и репродуктологии имени Д.О. Отта»
Россия
Россия
аспирант,
Менделеевская линия, д. 3, Санкт-Петербург, 199034
М. С. Зайнулина
ФГБОУ ВО «Первый Санкт-Петербургский государственный медицинский университет имени академика И.П. Павлова» Минздрава России;
Санкт-Петербургское учреждение здравоохранения «Родильный дом №6 им. проф. В.Ф. Снегирева»
Россия
Россия
д.м.н., профессор кафедры акушерства и гинекологии, ул. Льва Толстого, д. 6-8, Санкт-Петербург, 197022;
главный врач, ул. Маяковского д. 5, Санкт-Петербург, 191014
С. А. Сельков
ФГБНУ «НИИ акушерства гинекологии и репродуктологии имени Д.О. Отта»
Россия
Россия
д.м.н., профессор, руководитель отдела иммунологии и межклеточных взаимодействий, заслуженный деятель науки РФ,
Менделеевская линия, д. 3, Санкт-Петербург, 199034
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Рецензия
Для цитирования:
Кривонос М.И., Зайнулина М.С., Сельков С.А. АНТИФОСФОЛИПИДНЫЙ СИНДРОМ И РАННИЕ РЕПРОДУКТИВНЫЕ ПОТЕРИ. Акушерство, Гинекология и Репродукция. 2016;10(4):114-122. https://doi.org/10.17749/2313-7347.2016.10.4.114-122
For citation:
Krivonos M.I., Zainulina M.S., Selkov S.A. ANTIPHOSPHOLIPID SYNDROME AND EARLY REPRODUCTIVE FAILURE. Obstetrics, Gynecology and Reproduction. 2016;10(4):114-122. (In Russ.) https://doi.org/10.17749/2313-7347.2016.10.4.114-122
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