PERINATAL BRAIN INJURY: CURRENT ISSUES OF EPIDEMIOLOGY AND APPROACHES TO CLASSIFICATION
https://doi.org/10.17749/2313-7347.2016.10.4.084-093
Abstract
Perinatal brain ingury including hypoxic-ischemic encephalopathy (HIE) is serious problem of healthcare. Data on HIE prevalence in Russia is quite heterogeneous. Generally, prevalence in Russia is higher than in developed countries. The article presents the existing data on the prevalence of HIE in Russia, modern approaches to definition and classification. Large-scale studies and register could be helpful for further verification of the prevalence, incidence, outcomes and other measures. It is also important to further systematization of criteria for the diagnosis of perinatal CNS lesions. The usage of common approaches in routine practice, such as the RASPM classification, Sarnat classification, Levene classification would be helpful for epidemiological studies and for unifying approaches to the management of patients in order to prevent over-diagnosis and ensure proper choise of treatment.
About the Author
D. V. Blinov
FSBE HE N.I. Pirogov RNRMU MOH Russia
Russian Federation
Russian Federation
PhD,
ul. Ostrovitianova, 1, Moscow, 117997
References
1. Antonova O.M. Neuron specific enolase and its role in the mechanisms of the antibody into the brain aggression. PhD diss. [Neirospetsificheskaya enolaza i ee rol' v mekhanizmakh antitel'noi agressii v mozg. Diss. …kand. med. nauk (in Russian)]. Moscow. 1997; 121 s.
2. Barashnev Yu.I., Kulakov V.I. Infants at high risk. New diagnostic and therapeutic technologies [Novorozhdennye vysokogo riska. Novye diagnosticheskie i lechebnye tekhnologii (in Russian)]. Moscow. 2006; 528 s.
3. Volodin N.N. Perinatologiya. Perinatology. Milestones. Development prospects. Acts referred to in SMU [Istoricheskie vekhi. Perspektivy razvitiya. Aktovaya rech' v RGMU (in Russian)]. Moscow. 2006; 48 s.
4. Gannushkina I.V. The pathophysiology of disorders of cerebral circulation. Bk. Brain: theoretical and clinical aspects. Ed. Pokrovsky VI [Patofiziologiya narushenii mozgovogo krovoobrashcheniya. Kn. Mozg: teoreticheskie i klinicheskie aspekty. Pod red. Pokrovskogo V.I. (in Russian)]. Moscow. 2003; 463-489.
5. Degtyareva M.G. Dynamic control of the functional state of the CNS in children with perinatal posthypoxic brain damage in the first year of life. PhD diss. [Dinamicheskii kontrol' funktsional'nogo sostoyaniya TsNS u detei s perinatal'nymi postgipoksicheskimi porazheniyami golovnogo mozga na pervom godu zhizni. Diss. …kand. med. nauk. (in Russian)]. Moscow. 2002; 254 s.
6. Zhurba L.T., Mastyukova E.M. Neurodevelopmental impairment in infants [Narushenie psikhomotornogo razvitiya detei pervogo goda zhizni (in Russian)]. Moscow. 1981; 272 s.
7. Kaz'min A.M., Daikhina L.V., Ozerova O.E. Zhurnal materinstvo i detstvo. 1992; 37 (4-5): 8-13.
8. Classification of perinatal lesions of the nervous system in newborns. Guidelines [Klassifikatsiya perinatal'nykh porazhenii nervnoi sistemy u novorozhdennykh. Metodicheskie rekomendatsii (in Russian)]. Moscow. 2000; 40 s.
9. The classification of the consequences of perinatal lesions of the nervous system in newborns. Guidelines [Klassifikatsiya posledstvii perinatal'nykh porazhenii nervnoi sistemy u novorozhdennykh. Metodicheskie rekomendatsii (in Russian)]. Moscow. 2005; 40 s.
10. Classification of perinatal lesions of the nervous system and their consequences for children of the first year of life (guidelines). Questions of Practical Pediatrics [Klassifikatsiya perinatal'nykh porazhenii nervnoi sistemy i ikh posledstvii u detei pervogo goda zhizni (metodicheskie rekomendatsii). Voprosy Prakticheskoi Pediatrii (in Russian)]. 2006; 1: 5-32.
11. International Statistical Classification of Diseases and Related Health. Tenth revision. In 2 volumes. World Health Organization. Geneva [Mezhdunarodnaya statisticheskaya klassifikatsiya boleznei i problem, svyazannykh so zdorov'em. Desyatyi peresmotr. V 2 tomakh. Vsemirnaya organizatsiya zdravookhraneniya (in Russian)]. Geneva. 1995.
12. Mukhtarova S.N. Meditsinskie Novosti Gruzii. 2010; 4 (181): 49-54.
13. New approaches to the diagnosis of perinatal lesions of the nervous system in infants and their classification. Group of authors. Pediatrics [Novye podkhody k diagnostike perinatal'nykh porazhenii nervnoi sistemy u detei pervogo goda zhizni i ikh klassifikatsiya. Kollektiv avtorov. Pediatriya. (in Russian)]. 2004; 1: 1-5.
14. Pal'chik A.B., Shabalov N.P. Hypoxic-ischemic encephalopathy newborns [Gipoksicheski-ishemicheskaya entsefalopatiya novorozhdennykh (in Russian)]. Moscow. 2013; 288 s.
15. Order of the Ministry of Health and Social Development of the Russian Federation of December 27, 2011 N 1687n "On the medical criteria of birth, form of the birth and the order of issuance" [Prikaz Ministerstva zdravookhraneniya i sotsial'nogo razvitiya Rossiiskoi Federatsii ot 27 dekabrya 2011 g. N 1687n «O meditsinskikh kriteriyakh rozhdeniya, forme dokumenta o rozhdenii i poryadke ego vydachi» (in Russian)].
16. Order of the RF Ministry of Health on January 16, 2013 N 7N "On Amendments to the Annex N 1 and N 3 to the Order of the Russian Federation of Health and Social development, Ministry of December 27, 2011 N 1687n" On the medical criteria of birth, document form birth order and its delivery" [Prikaz Ministerstva zdravookhraneniya RF ot 16 yanvarya 2013 g. N 7n «O vnesenii izmenenii v prilozheniya N 1 i N 3 k prikazu Ministerstva zdravookhraneniya i sotsial'nogo razvitiya Rossiiskoi Federatsii ot 27 dekabrya 2011 g. N 1687n «O meditsinskikh kriteriyakh rozhdeniya, forme dokumenta o rozhdenii i poryadke ego vydachi» (in Russian)].
17. Rogatkin S.O. Diagnosis, prevention and treatment of perinatal posthypoxic lesions of the central nervous system in newborns and young children. PhD diss. [Diagnostika, profilaktika i lechenie perinatal'nykh postgipoksicheskikh porazhenii tsentral'noi nervnoi sistemy u novorozhdennykh i detei rannego vozrasta. Diss. …dokt. med. nauk (in Russian)]. Moscow. 2012; 284 s.
18. Tsybelova E.M. Sibirskii Meditsinskii zhurnal. 2007; 6: 27-31.
19. Chekhonin V.P., Dmitrieva T.B., Zhirkov Yu.A. Imunochemical analysis of antigens neurospecifical [Immunokhimicheskii analiz neirospetsificheskikh antigenov (in Russian)]. Moscow. 2000; 416 s.
20. Yakunin Yu.A., Yampol'skaya E.I., Kipnis S.L., Sysoeva I.M. Diseases of the nervous system in infants and young children [Bolezni nervnoi sistemy u novorozhdennykh i detei rannego vozrasta (in Russian)]. Moscow. 1979; 280 s.
21. Yakunin Yu.A., Perminov V.S. Ros. Vest. perinat. i ped. 1993; 38 (2): 20-24.
22. Antonucci R., Porcella A., Pilloni M.D. Perinatal asphyxia in the term newborn. Journal of Pediatric and Neonatal Individualized Medicine. 2014; 3 (2): e030269. DOI: 10.7363/030269.
23. Basys V., Drazdiene N., Vezbergiene N., Isakova J. Perinatal injury of the central nervous system in Lithuania from 1997 to 2014. Acta Medica Lituanica. 2016; 23 (4): 199-205.
24. Berger R., Garnier Y., Pathophysiology of perinatal brain damage. Brain. Res. Rew. 1999; 30: 107-134.
25. de Haan M., Wyatt J.S, Roth S., VarghaKhadem F., Gadian D., Mishkin M. Brain and cognitive-behavioural development after asphyxia at term birth. Dev Sci. 2006; 9: 350-8.
26. de Vries L., Jongmans M. Long-term outcome after neonatal hypoxic ischaemic encephalopathy. Arch Dis Child Fetal Neonatal Ed. 2010; 95: F220–4.
27. Eng L.F., Ghirnikar R.S., Lee Y.L. Glial fibrillary acidic protein: GFAP-thirty-one years (1969-2000). Neurochem. Res. 2000; 9-10: 1439-1451.
28. Glass H.C. et al. Clinical Neonatal Seizures are Independently Associated with Outcome in Infants at Risk for Hypoxic-Ischemic Brain Injury. J. Pediatr. 2009; 155: 318-323.
29. Gluckman P.D., Wyatt J.S., Azzopardi D. et al. Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: multicenter randomized trial. Lancet. 2005; 365: 663-670.
30. Greishen G. Ischaemia of the preterm brain. Biol. Neonate. 1992; 62: 243-247.
31. Haataja L., Mercuri E., Regev R., Cowan F., Rutherford M., Dubowitz V., Dubowitz L. Optimality score for the neurologic examination of the infant at 12 and 18 months of age. J. Pediatr. 1999; 135 (2 Pt 1): 153-161.
32. Huppi P.S., Warfield S., Kikinis R., Barnes P.D., Zientara G.P., Jolesz F.A., Tsuji M.K., Volpe J.J. Quantitative magnetic resonance imaging of brain development in premature and mature newborns. Ann. Neurol. 1998; 43 (2): 224-35.
33. Lawn J.E., Cousens S., Zupan J. and for the Lancet Survival Steering team. 4 million neonatal deaths: when? Where? Why? Lancet. 2005; 365: 891-900.
34. Levene M. Role of excitatory amino acid antagonists in the management of birth asphyxia. Biol Neonate. 1992; 62: 248-251.
35. Levene M.I. The asphyxiated newborn infant. In: Levene MI, Lilford RJ. Fetal and neonatal neurology and neuro-surgary. Edinburgh: Churchil Livingstone. 1995: 405-426.
36. Palmer C. Neurobiology of perinatal asphyxia. Penn. State Coll. Med. 2001; 1: 1-18.
37. Pin T.W., Eldridge B., Galea M.P. A review of developmental outcomes of term infants with post-asphyxia neonatal encephalopathy. Eur. J. Paediatr. Neurol. 2009; 13 (3): 224-234.
38. Relation between perinatal factors and neurological outcome. In: Guidelines for Perinatal Care. 3rd ed. Elk Grove Village, Ill: American Academy of Pediatrics. 1992; 221-234.
39. Ronen G.M. et al. The epidemiology of clinical neonatal seizures in Newfoundland: a
40. population-based study. J. Pediatr. 1999; 134: 71-75.
41. Sarnat H.B., Sarnat M.S. Neonatal encephalopathy following fetal distress. Arch Neurol. 1976; 33: 698-705.
42. Shankaran S., Laptook A.R., Ehrenkranz R.A. et al. Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy. N. Engl. J. Med. 2005; 353 (15): 1574-1584.
43. van Handel M., Swaab H., de Vries L. S., Jongmans M. J. Long-term cognitive and behavioral consequences of neonatal encephalopathy following perinatal asphyxia: a review. Eur. J. Pediatr. 2007; 166 (7): 645-654.
44. Vasudevan C., Levene M. Epidemiology and aetiology of neonatal seizures. Semin. Fetal Neonatal Med. 2013; 18: 185-191.
45. Volpe J.J. Neurology of the Newborn. Saunders Elsevier. 2008; p. 1120.
46. Volpe J.J. Perinatal brain injury: from pathogenesis to neuroprotection. Ment. Retard. Dev. Disabil. Res. Rev. 2001; 7 (1): 56-64.
47. Zanelli S.A, Stanley D. P., Kaufman D. Hypoxic-ischemic encephalopathy. 2012.
Review
For citations:
Blinov D.V. PERINATAL BRAIN INJURY: CURRENT ISSUES OF EPIDEMIOLOGY AND APPROACHES TO CLASSIFICATION. Obstetrics, Gynecology and Reproduction. 2016;10(4):84-93. (In Russ.) https://doi.org/10.17749/2313-7347.2016.10.4.084-093
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