Preview

Obstetrics, Gynecology and Reproduction

Advanced search

THROMBOPHILIA AS A FACTOR OF ETHIOLOGY AND PATHOGENESYS OF DISORDERS IN THE SYSTEM “WOMAN – FETUS – NEWBORN”

https://doi.org/10.17749/2313-7347.2016.10.4.021-029

Full Text:

Abstract

Objective: the assessment of a condition of health of women with antiphospholipid syndrome (APS) and hereditary thrombophilia (HT) and a condition of health their newborn children.

Materials and Methods. We examine clinically and by laboratorial and special exams (coagulogram, polymerase chain reaction diagnostics of genetics of hemostasis, ultrasonography of fetus at I, II, III trimester of pregnancy, doppler ultrasonography of blood flow in umbilical arteries, cardiotocography) 92 women with thrombophilia and their 92 newborn children (neurosonography, fundoscopy, abdominal ultrasound, nephrosonography, ultrasonography of hip joint).

Results. The somatic anamnesis was more often burdened by vegetative dystonia syndrome (82.61%) at women with APS and by prolapse of the mitral valve (30.43%) and myopia (28.26%) at women with HT. In high percentage of cases fetoplacental insufficiency (60.78% at women with APS and 67.39% at women with HT), threatened miscarriage (50,00% at women with APS and 65.22% at women with HT) and cervical erosion (23.91% at women with APS and 45,65% at women with HT) was peculiarity of obstetric and gynecology anamnesis at all women with thrombophilia. Hypoxic-ischemic encephalopathy (78.26%), conjugation jaundice (56.52%) and morphofunctional dismaturity (45.65%) was diagnosed more often at children who was born to the women with APS and hypoxic-ischemic encephalopathy (65.96%) and intrauterine growth restriction (34.04%) was diagnosed at children who was born to the women with HT.

Conclusion. Rather high percentage of diseases at women with thrombophilia and at their newborn children claim further development the therapy algorithm in the system “woman – fetus – newborn” with the case of decrease of the morbidity and improvement of social adaptation of newborn children in the future.

About the Authors

A. Ya. Il'ina
Pirogov Russian National Research Medical University
Russian Federation

MD, Professor of the Department of Hospital Pediatrics named after Academician VA Tabolin,

ul. Ostrovityanova, 1, Moscow, 117997



P. V. Shumilov
Pirogov Russian National Research Medical University
Russian Federation

MD, Head of the Department of Hospital Pediatrics named after Academician VA Tabolin, 

ul. Ostrovityanova, 1, Moscow, 117997



A. L. Mishchenko
First Moscow State Medical Sechenov University of the Ministry of Health Russian Federation
Russian Federation

MD, Leading Researcher of the Research Center "Clinical Hemostasis", 

ul. Trubetskaya, 8, str. 2, Moscow, 119048



A. S. Barinova
Pirogov Russian National Research Medical University
Russian Federation

intern of the Department of Hospital Pediatrics named after Academician VA Tabolin, 

ul. Ostrovityanova, 1, Moscow, 117997



I. Yu. Kokaya
City Clinical Hospital №52 of the Department of Health of Moscow – branch
Russian Federation

Candidate of Medicine, the deputy chief physician at the medical unit, obstetrician-gynecologist of the highest qualification category,

ul. Sosnovaya, 11, Moscow, 123182



V. N. Kashin
City Clinical Hospital №52 of the Department of Health of Moscow – branch
Russian Federation

Candidate of Medicine, Head of I obstetric physiological department, obstetrician-gynecologist of the highest qualification category,

ul. Sosnovaya, 11, Moscow, 123182



O. S. Pobedinskaya
First Moscow State Medical Sechenov University of the Ministry of Health Russian Federation
Russian Federation

Candidate of Medicine, obstetrician-gynecologist of the Clinic of Obstetrics and Gynecology named after VF Snegirev, 

ul. Elanskogo, 2-1, Moscow, 119435



I. V. Solov'eva
City Clinical Hospital №52 of the Department of Health of Moscow – branch
Russian Federation

Head of neonatal department, neonatologist of the highest qualification category,

ul. Sosnovaya, 11, Moscow, 123182



T. S. Kharlamova
City Clinical Hospital №52 of the Department of Health of Moscow – branch
Russian Federation

neonatologist of the second qualification category of neonatal department,

ul. Sosnovaya, 11, Moscow, 123182



A. V. Budancev
City Clinical Hospital №52 of the Department of Health of Moscow – branch
Russian Federation

head of emergency department for newborns, anaesthesiologist resuscitator of the high qualification category,

ul. Sosnovaya, 11, Moscow, 123182



E. A. Akhalova
Pirogov Russian National Research Medical University
Russian Federation

intern of the Department of Hospital Pediatrics named after Academician VA Tabolin, 

ul. Ostrovityanova, 1, Moscow, 117997



References

1. Akin'shina S.V., Makatsariya A.D., Bitsadze V.O., Andreeva M.D. Akusherstvo, ginekologiya i reproduktsiya/ Obstetrics, gynecology and reproduction. 2014; 4: 27-36.

2. Vashukova E.S., Glotov A.S., Bikmullina D.R., Zainulina M.S., Baranov V.S. Meditsinskaya genetika. 2010; 11: 39-45

3. Gubar' T.K., Alekseeva L.L., Sturov V.G. Vestnik Buryatskogo Gosudarstvennogo Universiteta. 2015; 12: 107-109.

4. Il'inaA.Ya. Modern problems of the health of the early neonatal period, infants born to women with cardiovascular pathology, APS and violation antiendotoxic immunity. MD diss. [Sovremennye problem sostoyaniya zdorov'ya novorozhdennykh rannego neonatal'nogo perioda, rodivshikhsya u zhenshchin s kardiovaskulyarnoi patologiei, AFS i narusheniem antiendotoksinovogo immuniteta. Diss. …dokt. med. nauk (in Russian)]. Moscow. 2004.

5. Il'ina A.Ya., Shumilov P.V., Turkina T.I., Kirillova N.I., Barinova A.S., Kuzin I.I., Mishchenko A.L., Kokaya I.Yu., Kashin V.N., Pobedinskaya O.S. «Pediatriya» zhurnalim. G.N. Speranskogo. 2016; 74-84.

6. Kovtun O.P., Baranov D.A., Kuznetsov N.N., Plaksina A.N. Vestnik Ural'skoi meditsinskoi akademicheskoi nauki. 2011; 4: 131-136.

7. Makatsariya A.D., Bitsadze V.O., Baimuratova S.M., Dolgushina N.V., Yudaeva L.S., Khirzoeva D.Kh., Akin'shina S.V. Antiphospholipid syndrome – immune thrombophilia in obstetrics and gynecology [Antifosolipidnyi sindrom – immunnaya trombofiliya v akusherstve i ginekologii (in Russian)]. Moscow. 2013.

8. Makatsariya A.D., Chervenak F.A., Bitsadze V.O. High Risk Pregnancy [Beremennost' vysokogoriska (in Russian)]. Moscow. 2015.

9. Sostojanie zdorov'ja beremennyh, rozhenic, rodil'nic i novorozhdennyh (Dannye Minzdrava Rossii, raschet Rosstata), Obnovleno 25.11.2016. http://www.gks.ru/. Accessed: 28.11.16.

10. Statistical Bulletin. The natural movement of the population of the Russian Federation for 2015.Federal State Statistics Service [Statisticheskii byulleten'. Estestvennoe dvizhenie naseleniya Rossiiskoi Federatsii za 2015 god. Federal'naya sluzhba gosudarstvennoi statistiki (in Russian)]. Moscow. 2016.

11. Sukhikh G.T. Mat' i Ditya. 2015; 2: 1-3.

12. Shumilov P.V., Il'inaA. Ya., Kokaya I.Yu., Kashin V.N., Barinova A.S., Kirillova N.I., Chugunova E.A., Tseloeva Kh.I., Shifrin Yu.A. Rossiiskii vestnik perinatologyii i pediatrii. 2015; 60: 165.

13. Shumilov P.V., Il'inaA.Ya., Mishchenko A.L., Kirillova N.I., Naumenko M.G., Aleshcheva A.S. «Pediatriya» zhurnalim. G.N. Speranskogo. 2014; 93 (1): 10-16.


For citation:


Il'ina A.Y., Shumilov P.V., Mishchenko A.L., Barinova A.S., Kokaya I.Y., Kashin V.N., Pobedinskaya O.S., Solov'eva I.V., Kharlamova T.S., Budancev A.V., Akhalova E.A. THROMBOPHILIA AS A FACTOR OF ETHIOLOGY AND PATHOGENESYS OF DISORDERS IN THE SYSTEM “WOMAN – FETUS – NEWBORN”. Obstetrics, Gynecology and Reproduction. 2016;10(4):21-29. (In Russ.) https://doi.org/10.17749/2313-7347.2016.10.4.021-029

Views: 180


ISSN 2313-7347 (Print)
ISSN 2500-3194 (Online)