EXPERIENCE OF CONDUCTING PREGNANCY AT THE SENSITIZATION TO THE HORIONICHESKY GONADOTROPHIN OF THE PERSON
https://doi.org/10.17749/2313-7347.2016.10.2.018-023
Abstract
Objective. Studying of a role of circulation of antibodies to HG during gestational process at pregnant women about pregnancy not incubation was the purpose. Materials and Methods. Selection was made by 40 women with a sensibilization to HG and pregnancy not incubation threat (the main group), and 20 pregnant women with lack of antibodies to HG, but with a similar clinical picture (group of comparison) aged from 19 till 39 years. Except the researches regulated by Orders of the Ministry of Health of Ukraine from individual consent of the woman research at 35 patients (21 women of the main group and 14 women from group of comparison) the maintenance of pro-inflammatory cytokines (IL-6 and ТNF-α), and also the level of lymphocytes with a phenotype of CD56+16+ and CD19+5 + in blood serum by IFA method is in addition conducted. Results. Reliable correlation communication between presence of the increased level of antibodies to HG and episodes of formation of hematomas behind a horion in І-st pregnancy trimester, a hypercoagulative syndrome, the IL-6 levels and TNF-α is revealed. Thus it is proved that existence of the circulating antibodies to HG leads to thrombosis changes that major factors of risk of development of complications of a gestation and thromboembolic complications. Conclusion. It is confirmed that symptomatic therapy in the course of the pregnancy complicated by threat of an abortion isn't pathogenetic reasonable and effective. An important point is influence on an immune component at a stage of preconception. It explains need of individualization of therapeutic approaches to maintaining women with habitual not incubation of pregnancy which will consider the immunological reasons of not incubation of pregnancy.
About the Authors
Z. M. Dubossarskaya
Dnepropetrovsk Medical Academy of the Ministry of Health of Ukraine, Dnepropetrovsk
Ukraine
Ukraine
Dubossarskaya Zinaida Mikhailovna – MD, professor of the Department of Obstetrics, Gynecology and perinatology, Faculty of postdegree formation of Public institution.
Address: ul. Dzerzhinskogo, 9, Dnipropetrovsk, Ukraine, 49044
Y. M. Duka
Dnepropetrovsk Medical Academy of the Ministry of Health of Ukraine, Dnepropetrovsk
Russian Federation
Russian Federation
Duka Yuliya Mikhailovna – MD, associate professor of the Department of Obstetrics, Gynecology and perinatology, Faculty of postdegree formation of Public institution.
Corresponding author Address: ul. Dzerzhinskogo, 9,Dnepropetrovsk, Ukraina, 49044. E-mail: rduka@ukr.net (Duka Y.M.).
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Review
For citations:
Dubossarskaya Z.M., Duka Y.M. EXPERIENCE OF CONDUCTING PREGNANCY AT THE SENSITIZATION TO THE HORIONICHESKY GONADOTROPHIN OF THE PERSON. Obstetrics, Gynecology and Reproduction. 2016;10(3):18-23. (In Russ.) https://doi.org/10.17749/2313-7347.2016.10.2.018-023
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