FOLATE DEFICIENCY IN OBSTETRICS AND THE PROBLEM OF ITS CORRECTION
https://doi.org/10.17749/2313-7347.2015.10.1.038-048
Abstract
The article considers the reasons and the role of the folate deficiency in development of the complicated pregnancy and congenital malformations. The biological functions of folate in an organism are described, as well as the role of folate in an exchange of methionine and a hyperhomocysteinemia as one of the reasons of malformations and complications of pregnancy. The role of a genetic mutation of MTHFR as the hyperhomocysteinemia reasons at patients with deficiency of folate and the treatment of the state of the deficiency of folate are discussed.
About the Authors
V. O. Bitsadze
First Moscow State Medical Sechenov University of the Ministry of Health Russian Federation
Russian Federation
Russian Federation
MD, Professor, Department of Obstetrics and Gynecology, First Moscow State Medical Sechenov University. Address: ul. Trubetskaya, 8, str. 2, Moskva, Russia, 119048. Tel.: +7(495)7885840
N. V. Samburova
First Moscow State Medical Sechenov University of the Ministry of Health Russian Federation
Russian Federation
Russian Federation
Assistant professor, Department of Pathophysiology, First Moscow State Medical Sechenov University. Address: ul. Trubetskaya, 8, str. 2, Moskva, Russia, 119048. Tel.: +7(495)7885840
N. A. Makatsariya
First Moscow State Medical Sechenov University of the Ministry of Health Russian Federation
Russian Federation
Russian Federation
Assistant of the Department of Obstetrics and Gynecology, First Moscow State Medical Sechenov University. Address: Trubetskaya str., 8, p. 2, Moscow, Russia, 119048 Тел.: +7(903)1182433
A. L. Mishchenko
First Moscow State Medical Sechenov University of the Ministry of Health Russian Federation
Russian Federation
Russian Federation
MD, research assistance of Scientific Educational Clinical Centre «Clinical Hemostasiology», First Moscow State Medical Sechenov University. Address: ul. Trubetskaya, 8, str. 2, Moskva, Russia, 119048. Tel.: +7(495)7885840
References
1. High Risk Pregnancy. Ed. A.D. Makatsariya, F.A. Chervenak, V.O. Bitsadze. [Beremennost' vysokogo riska. Pod red. A.D. Makatsariya, F.A. Chervenaka, V.O. Bitsadze (in Russian)]. Moscow. 2015; 789-799.
2. Bitsadze V.O., Baimuradova S.M., Talalaeva I.N. Zhurnal ROAG. 2008; 2: 42-48.
3. Dobrokhotova Yu.E., Sukhikh G.T., Dzhobava E.M. i dr. Rossiiskii vestnik akusheraginekologa. 2007; 5: 8-11.
4. Makatsariya A.D., Beloborodova E.V., Baimuradova S.M., Bitsadze V.O. Hyperhomocysteinemia and pregnancy complications [Gipergomotsisteinemiya i oslozhneniya beremennosti (in Russian)]. Moscow. 2005.
5. Pustotina O.A., Akhmedova A.E. Akusherstvo i ginekologiya. 2014; 3 (35).
6. Bailey L.B., Berry R. Folic acid supplementation and the occurrence of congenital heart defects, orofacial clefts, multiple births, and miscarriage. Am. J. Clin. Nutr. 2005; 81 (5): 1213-1217.
7. Beaudin A.E., Stover P.J. Folate-mediated onecarbon metabolism and neural tube defects: balancing genome synthesis and gene expression. Birth Defects Res. C. Embryo Today. 2007; 81 (3): 183-203.
8. Bergen N.E. et al. Homocysteine and folate concentrations in early pregnancy and the risk of adverse pregnancy outcomes: the Generation R Study. BJOG. 2012; 119 (6):
9. 739-51.
10. Blencowe H., Cousens S., Modell B. et al. Folic acid to reduce neonatal mortality from neural tube disorders. Int. J. Epidemiol. 2010; 39 (1): 110-121.
11. Bodnar L.M., Himes K.P., Venkataramanan R. et al. Maternal serum folate species in early pregnancy and risk of preterm birth. Am. J. Clin. Nutr. 2010; 92 94): 864-871.
12. Bukowski R., Malone F.D., Porter F.T. et al. Preconceptional folate supplementation and the risk of spontaneous preterm birth: a cohort study. PLoS Med. 2009; 6 (5). ID 1000061.
13. Crider K.S., Yang T.P., Berry R.J. et al. Folate and DNA methylation: a review of molecular mechanisms and the evidence for folate’s role. Adv. Nutr. 2012; 3 (1): 21-38.
14. Czeizel A.E., Puho E.H., Langmar Z. et al. Possible association of folic acid supplementation during pregnancy with reduction of preterm birth: a population-based study. Eur. J. Obstet. Gynecol. Reprod. Biol. 2010; 148 (2): 135-140.
15. Daly L.E., Kirke P.N., Molloy A. et al. Folate levels and neural tube defects: implications for prevention. JAMA. 1995; 274 (21): 1698-1702.
16. Fekete K., Berti C., Trovato M. et al. Effect of folate intake on health outcomes in pregnancy: a systematic review and meta-analysis on birth weight, placental weight and length of gestation. Nutr. J. 2012; 11: 75-86.
17. Greenberg J.A., Bell S.J., Guan Y. et al. Folic acid supplementaion and pregnancy: more than just neural tube defect prevention. Rev. Obstet. Gynecol. 2011; 4 (2): 52-59.
18. Kim M.W., Hong S.C., Choi J.S. et al. Homocysteine, folate and pregnancy
19. outcomes. J. Obstet. Gynaecol. 2012; 32 (6): 520-524.
20. Lucock M. Folic acid: nutritional biochemistry, molecular biology, and role in disease processes. Mol. Genet. Metab. 2000; 71 (1-2): 121-138.
21. Micle O., Muresan M., Antal L. et al. The influence of homocysteine and oxidative stress on pregnancy outcome. J. Med. Life. 2012; 5 (1): 68-73.
22. Pietrzik K., Bailey L., Shane B. Folic acid and L-5-methyltetrahydrofolate: comparison of clinical pharmacokinetics and pharmacodynamics. Clin. Pharmacokinet. 2010; 49 (8): 535-548.
23. Prinz-Langenohl R., Brämswig S., Tobolski O. et al. (6S)-5-methyltetrahydrofolate increases plasma folate more effectively than folic acid in
24. women with the homozygous or wild-type 677C>T polymorphism of methylenetetrahydrofolate reductase. Br. J. Pharmacol. 2009; 158 (8): 2014-2021.
25. Ptikin R.M. Folate and neural tube defects. Am. J. Clin. Nutr. 2007; 85 (1): 285-288.
26. Puri M., Kaur L., Walia G.K. et al. MTHFR C677T polymorphism, folate, vitamin B12 and homocysteine in recurrent pregnancy losses: a case control study among North Indian women. J. Perinat. Med. 2013; 41 (5): 549-554.
27. Roth C. et al. Folic acid supplements in pregnancy and severe language delay in children. JAMA. 2011; 306 (14): 1566-1573.
28. Stolzenberg-Solomon R.Z., Chang S.C., Leitzmann M.F. et al. Folate intake, alcohol use, and postmenopausal breast cancer risk in the prostate, lung, colorectal, and ovarian cancer screening trial. Am. J. Clin. Nutr. 2006; 83 (4): 895-904.
29. Timmermans S., Jaddoe V.W., Hofman A. et al. Periconception folic acid supplementation, fetal growth and the risks of low birth weight and preterm birth: the Generation R Study. Br. J. Nutr. 2009; 102 (5): 777-785.
30. Van Beynum I.M., Kapusta L., Bakker M.K. et al. Protective effect of periconceptional folic acid supplements on the risk of congenital heart defects: a registry-based case-control study in the northern Netherlands. Eur. Heart J. 2010; 31 (4): 464-471.
31. Vollset S.E., Refsum H., Irgens L.M. et al. Plasma total homocysteine, pregnancy
32. complications, and adverse pregnancy outcomes: the Hordaland Homocysteine study. Am. J. Clin. Nutr. 2000; 71 (4): 962-968.
33. Williams P.J., Bulmer J.N., Innes B.A. et al. Possible roles for folic acid in the regulation of trophoblast invasion and placental development in normal early human pregnancy. Biol. Reprod. 2011; 84 (6): 1148-1153.
34. Human Vitamin and Mineral Requirements. World health organization food snd agriculture organization of the united nations, 2004 (Second Edition).
35. CDC. CDC Grand Rounds: Additional Opportunities to Prevent Neural Tube Defects with Folic Acid Fortification. MMWR. 2010; 59 (31); 980-4.
36. Nohr E.A., Olsen J., Bech B.H. et al. Periconceptional intake of vitamins and fetal death: a cohort study on multivitamins and folate. Int J Epidemiol. 2014; 43 (1): 174-84.
Review
For citations:
Bitsadze V.O., Samburova N.V., Makatsariya N.A., Mishchenko A.L. FOLATE DEFICIENCY IN OBSTETRICS AND THE PROBLEM OF ITS CORRECTION. Obstetrics, Gynecology and Reproduction. 2016;10(1):38-48. (In Russ.) https://doi.org/10.17749/2313-7347.2015.10.1.038-048
Views:
1116
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Email this article 
