FOLATE DEFICIENCY IN OBSTETRICS AND THE PROBLEM OF ITS CORRECTION
Abstract
The article considers the reasons and the role of the folate deficiency in development of the complicated pregnancy and congenital malformations. The biological functions of folate in an organism are described, as well as the role of folate in an exchange of methionine and a hyperhomocysteinemia as one of the reasons of malformations and complications of pregnancy. The role of a genetic mutation of MTHFR as the hyperhomocysteinemia reasons at patients with deficiency of folate and the treatment of the state of the deficiency of folate are discussed.
About the Authors
V. O. Bitsadze
First Moscow State Medical Sechenov University of the Ministry of Health Russian Federation
Russian Federation
Russian Federation
MD, Professor, Department of Obstetrics and Gynecology, First Moscow State Medical Sechenov University. Address: ul. Trubetskaya, 8, str. 2, Moskva, Russia, 119048. Tel.: +7(495)7885840
N. V. Samburova
First Moscow State Medical Sechenov University of the Ministry of Health Russian Federation
Russian Federation
Russian Federation
Assistant professor, Department of Pathophysiology, First Moscow State Medical Sechenov University. Address: ul. Trubetskaya, 8, str. 2, Moskva, Russia, 119048. Tel.: +7(495)7885840
N. A. Makatsariya
First Moscow State Medical Sechenov University of the Ministry of Health Russian Federation
Russian Federation
Russian Federation
Assistant of the Department of Obstetrics and Gynecology, First Moscow State Medical Sechenov University. Address: Trubetskaya str., 8, p. 2, Moscow, Russia, 119048 Тел.: +7(903)1182433
A. L. Mishchenko
First Moscow State Medical Sechenov University of the Ministry of Health Russian Federation
Russian Federation
Russian Federation
MD, research assistance of Scientific Educational Clinical Centre «Clinical Hemostasiology», First Moscow State Medical Sechenov University. Address: ul. Trubetskaya, 8, str. 2, Moskva, Russia, 119048. Tel.: +7(495)7885840
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Review
For citations:
Bitsadze V.O., Samburova N.V., Makatsariya N.A., Mishchenko A.L. FOLATE DEFICIENCY IN OBSTETRICS AND THE PROBLEM OF ITS CORRECTION. Obstetrics, Gynecology and Reproduction. 2016;10(1):38-48. (In Russ.) https://doi.org/10.17749/2313-7347.2015.10.1.038-048
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