THE SOCIO-MEDICAL CHARACTERISTICS OF WOMEN WITH THREATENED PRETERM LABOR
Abstract
Objective: to investigate health and social factors leading to the emergence of threatening preterm birth.
Material and methods: This study was designed to evaluate the significance of social conditions, professional and material factors, obstetric and somatic history in 191 singleton spontaneous gestations, included 117 women with threatened preterm labor (О47.0 in ICD) and 74 women with physiological pregnancy. Inclusion criteria for the main group were abdominal pain and structural changes in the cervix (maturation and shortening less than 2 cm). Medical records were also a source of information about the complications and the outcome of pregnancy. We calculated odds ratio and produced a ranking number of risk factors threatened preterm labor.
Results: average general education, signs of a threatened abortion in the second trimester, smoking during pregnancy, asymptomatic bacteriuria and the presence of immunoglobulin G (IgG) antibody to Cytomegalovirus (CMV) are the most significant risk factors for threatened preterm labor.
Conclusion. It is necessary to conduct preconception preparation of women with above mentioned poor factors, as well as measures aimed at elimination of controllable risk factors, to reduce the likelihood of threatened preterm birth.
About the Authors
A. I. Malyshkina
Federal State Budgetary Institution "Ivanovo Research Institute of Maternity and Childhood named after V.N. Gorodkov" Ministry of Health of the Russian Federation;
State Budgetary Educational Institution of higher education "Ivanovo State Medical Academy" Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
MD, Associate professor, Director, ul. Pobedy, 20, Ivanovo, 153045;
Head of the department of obstetrics and gynecology, medical genetics, Sheremet'evskii proezd, 8, Ivanovo, 153000
A. O. Nazarova
State Budgetary Educational Institution of higher education "Ivanovo State Medical Academy" Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
PhD, Associate professor of the department of obstetrics and gynecology, medical genetics,
Sheremet'evskii proezd, 8, Ivanovo, 153000
A. A. Kozyrina
Federal State Budgetary Institution "Ivanovo Research Institute of Maternity and Childhood named after V.N. Gorodkov" Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Doctoral student,
ul. Pobedy, 20, Ivanovo, 153045
Yu. N. Zholobov
Federal State Budgetary Institution "Ivanovo Research Institute of Maternity and Childhood named after V.N. Gorodkov" Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
Doctoral student,
ul. Pobedy, 20, Ivanovo, 153045
S. B. Nazarov
Federal State Budgetary Institution "Ivanovo Research Institute of Maternity and Childhood named after V.N. Gorodkov" Ministry of Health of the Russian Federation
Russian Federation
Russian Federation
MD, Professor, assistant Director on science,
ul. Pobedy, 20, Ivanovo, 153045
References
1. Baranov I.I., Skripnichenko Yu.P., Tokova Z.Z., Kuz'mich I.N. Ginekologiya. 2014; 5: 90-93.
2. Dadak K., Makacarija A.D., Blinov D.V., Zimovina U.V. Akusherstvo, ginekologiya i reproduktsiya / Obstetrics, gynecology and reproduction. 2014; 2: 69-78.
3. The Cochrane Manual. Pregnancy and childbirth. Trans. from English. Ed. GT Sukhikh [Kokranovskoe rukovodstvo. Beremennost' i rody. Per. s angl. Pod red. G.T. Sukhikh (in Russian)]. Moscow. 2010; 152-184.
4. Makarov O.V., Bakhareva I.V., Kuznetsov P.A., Romanovskaya V.V. Ros. vestnik akusherstva i ginekologii. 2007; 7: 10-15.
5. Radzinskii V.E., Kostin I.N. Akusherstvo i ginekologiya. 2009; 4: 16-19.
6. Andrews W., Goldenberg R., Mercer B. et al. The Preterm Prediction Study: Association of second-trimester genitourinary chlamydia infection with subsequent spontaneous preterm birth. American Journal of Obstetrics and Gynecology. 2000; 183 (3): 662-668.
7. Cnattingius S., Villamor E., Johansson S. et al. Maternal Obesity and Risk of Preterm Delivery. JAMA. 2013; 309 (22): 2362.
8. Cohen S., Doyle W., Baum A. Socioeconomic Status Is Associated With Stress Hormones. Psychosomatic Medicine. 2006; 68 (3): 414-420.
9. Fujiwara K., Tsukishima E., Kasai S. et al. Urinary catecholamines and salivary cortisol on workdays and days off in relation to job strain among female health care providers. Scand J Work Environ Health. 2004; 30 (2): 129-138.
10. Honest H., Bachmann L., Ngai C., Gupta J., Kleijnen J., Khan K. The accuracy of maternal anthropometry measurements as predictor for spontaneous preterm birth – a systematic review. European Journal of Obstetrics & Gynecology and Reproductive Biology. 2005; 119 (1): 11-20.
11. Katz V.L., Jenkins T., Haley L. et al. Catecholamine levels in pregnant physicians and nurses: a pilot study of stress and pregnancy. Obstet Gynecol. 1991; 77 (3): 338-342.
12. Kusanovic J., Espinoza J., Romero R. et al. Clinical significance of the pres-ence of amniotic fluid ‘sludge’ in asymptomatic patients at high risk for spontaneous preterm delivery. Ultrasound in Obstetrics and Gynecology. 2007; 30 (5): 706-714.
13. Lamont R. Infection in the prediction and antibiotics in the prevention of spontaneous preterm labour and preterm birth. BJOG: An International Journal of Obstetrics & Gynaecology. 2003; 110: 71-75.
14. Langenveld J., Jansen S., van der Post J., Wolf H., Mol B., Ganzevoort W. Recurrence Risk of a Delivery before 34 Weeks of Pregnancy Due to an Early Onset Hypertensive Disorder: A Systematic Review. Amer J Perinatol. 2010; 27 (7): 565-571.
15. Leitich H., Bodner-Adler B., Brunbauer M., Kaider A., Egarter C., Husslein P. Bacterial vaginosis as a risk factor for preterm delivery: A meta-analysis. American Journal of Obstetrics and Gynecology. 2003; 189 (1): 139-147.
16. Liu L., Johnson H., Cousens S. et al. Global, regional, and national causes of child mortality: an updated systematic analysis for 2010 with time trends since 2000. The Lancet. 2012; 379 (9832): 2151-2161. DOI:10.1016/s0140-6736(12)60560-1.
17. Romero R., Dey S., Fisher S. Preterm labor: One syndrome, many causes. Science. 2014; 345 (6198): 760-765.
18. Van der Beek A.J., Meijman T.F., Frings-Dresen M.H. et al. Lorry drivers’ work stress evaluated by catecholamines excreted in urine. Occup Environ Med. 1995; 52 (7): 464-469.
19. Van Os M., van der Ven J., Kazemier B. et al. Individualizing the risk for preterm birth: an overview of the literature. Expert Review of Obstetrics & Gynecology. 2013; 8 (5): 435-442.
For citation:
Malyshkina A.I., Nazarova A.O., Kozyrina A.A., Zholobov Y.N., Nazarov S.B. THE SOCIO-MEDICAL CHARACTERISTICS OF WOMEN WITH THREATENED PRETERM LABOR. Obstetrics, Gynecology and Reproduction. 2016;10(2):37-43. (In Russ.) https://doi.org/10.17749/2313-7347.2016.10.2.037-043
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