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A MODERN APPROACH TO THE TREATMENT OF COMPLICATED ECTOPIA OF THE CERVIX

https://doi.org/10.17749/2313-7347.2016.10.2.024-031

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Abstract

Objective. The research objective is the development of effective method for the treatment of complicated ectopia of the cervix, allowing to reduce the frequency of relapses.

Materials and methods. A comprehensive examination of 86 women with complicated ectopia of the cervix has been undertaken. In the main group (n=45) our proposed method of treatment of ectopia of the cervix has been applied, which, in addition to the performance of coagulation, involves two successive stages: preparing for coagulation and treatment in the postoperative period including Galavit (patent for invention № 2568768). In the comparison group (n=41) coagulation ectopia of uterine cervix was preceded by empirical antibiotic and antiviral therapy. Diagnostic measures included bacteriological and cytological examination, HPV testing, extended colposcopy, PCR diagnostic and ELISA blood test for the detection of causative agents of urogenital infections.

Results. The analysis of the postoperative period and control the colposcopy showed that in the majority of cases in the main group the reparative process ended by the end of the 3rd week (62.2%), the full impact of all the patients was recorded at the 5th week after the treatment (100%), the relapse has not been revealed within 2 years. In the comparison group the slowing down of terms of epithelialization of the wound surface of the uterus after coagulation has been noted, the lack of treatment effect has been found in 9.8% of patients, and the relapse within 2 years and 17.1% of women has been stated.

Conclusion. The developed method allows to increase the efficiency of treatment by sequential combined effects on cause and effect of pathological changes on the cervix: the elimination of etiopathogenetic factors ectopia of the cervix, coagulation of the pathological section, stimulation of the immune system and reparative processes.

About the Authors

Y. V. Mikheeva
Saratov state medical university named after V.I. Razumovsky
Russian Federation

postgraduate student of the Department of Obstetrics and Gynecology, faculty of Pediatrics,

ul. Bolshaya Kazachya, 112, Saratov, 410012



N. F. Khvorostukhina
Saratov state medical university named after V.I. Razumovsky
Russian Federation

PhD, associate professor, head of the Department of Obstetrics and Gynecology, Faculty of Pediatrics,

ul. Bolshaya Kazachya, 112, Saratov, 410012



D. A. Novichkov
Saratov state medical university named after V.I. Razumovsky
Russian Federation

candidate of medical sciences, associate professor of the Department of Obstetrics and Gynecology, Faculty of Pediatrics,

ul. Bolshaya Kazachya, 112, Saratov, 410012



References

1. Badretdinova F.F., Kortunova V.V. Akusherstvo, ginekologiya i reproduktsiya / Obstetrics, gynecology and reproduction. 2015; 1: 54-58.

2. Basova T.A. Evaluation of the clinical and laboratory diagnosis and quality treatment of chronic cervicitis in women of reproductive age in the outpatient. Dr. diss. [Ocenka jeffektivnosti kliniko-laboratornoj diagnostiki i povyshenie kachestva lechenija hronicheskogo cervicita u zhenshhin reproduktivnogo vozrasta v ambulatorno-poliklinicheskih uslovijah. Avtoref. Diss. … kand. med. nauk (in Russian)]. Saratov. 2012.

3. Burtushkina N.K., Kupert A.F. Sibirskij medicinskij zhurnal. 2011; 2: 74-76.

4. Vaganova S.E. Akusherstvo i ginekologija. 2010; 5: 116-120.

5. Vishnjakova S.V. Cervical condition after destructive treatments. Articles XIV All-Russian Scientific Forum "Mother and Child" [Materialy HIV Vserossijskogo nauchnogo foruma «Mat' i ditja» (in Russian)]. Moscow. 2013; 271-272.

6. Kozachenko V.P. Cancers: a guide for physicians [Onkoginekologija: rukovodstvo dlja vrachej (in Russian)]. Moscow. 2006.

7. Loginova E.O., Ajzikovich I.V., Trejvish L.S. i dr. Vestnik Novosibirskogo gosudarstvennogo universiteta. Serija: Biologija, klinicheskaja medicina. 2010; 8 (4): 201-202.

8. Minkina G.N., Rusakevich P.S. Cervical Disease [Zabolevanija shejki matki (in Russian)]. Minsk, 2000.

9. Ogrizko I.N., Semenov D.M. Vestnik Vitebskogo gosudarstvennogo medicinskogo universiteta. 2013; 12 (3): 72-77.

10. Ogrizko I.N. Ohrana materinstva i detstva. 2014; 2 (24): 43-47.

11. Panchenko V.V., Brjuhina E.V., Kazachkov E.L. Vestnik Juzhno-Ural'skogo gosudarstvennogo universiteta. Serija: Obrazovanie, zdravoohranenie, fizicheskaja kul'tura. 2014; 14 (1): 102-107.

12. Pat. 2568768 Russian Federation, MPK A 61 V 17/42, A 61 K 31/502, A 61 K 35/74, A 61 R 15/00. A method of treating cervical ectopia. Khvorostukhina NF, Novichkov DA, Mikheev YV, Stoljarova UV, Stepanova NN; the applicant and the patentee Saratov State. Number 2014145405/14; appl. 11/11/2014; publ. 20.11.2015, Bull. Number 32. [Sposob lechenija jektopii shejki matki. Hvorostuhina N.F., Novichkov D.A., Miheeva Ju.V., Stoljarova U.V., Stepanova N.N.; zajavitel' i patentoobladatel' Saratovskij GMU. № 2014145405/14; zajavl. 11.11.2014; opubl. 20.11.2015, Bjul. № 32 (in Russian)].

13. Prilepskaja V.N. Cervical Pathology and genital infections [Patologija shejki matki i genital'nye infekcii (in Russian)]. Moscow. 2008.

14. Rogovskaja S.I., Miheeva I.V., Shipulina O.Ju. Jepidemiologija i vakcinoprofilaktika. 2012; 1 (62): 25-33.

15. Rogovskaja S.I., Terebnjova L.A., Podzolkova N.M. Akusherstvo i ginekologija. 2014; 10: 95-103.

16. Rogovskaja S.I. Consilium Medicum. 2014; 16 (6): 51-55.

17. Firichenko S.V., Manuhin I.B., Minkina G.N. i dr. Ginekologija. 2013; 15 (4): 39-44.

18. Hajridinova D., Husainova M.B., Habirova S.Z. Vestnik poslediplomnogo obrazovanija v sfere zdravoohranenija. 2011; 3: 35-37.

19. Hvorostuhina N.F., Miheeva Ju.V., Novichkov D.A. i dr. Fundamental'nye issledovanija. 2014; 10 (3): 562-566.

20. Hvorostuhina N.F., Miheeva Ju.V., Novichkov D.A. Mezhdunarodnyj zhurnal prikladnyh i fundamental'nyh issledovanij. 2014; 5 (1): 155-156.

21. Churuksaeva O.N., Kolomiec L.A. Sibirskij onkologicheskij zhurnal. 2011; 3 (45): 11-15.

22. Hwang L.Y., Ma Y., Shiboski S.C. et al. Active squamous metaplasia of the cervical epithelium is associated with subsequent acquisition of human papillomavirus 16 infection among healthy young women. J. Infect. Dis. 2012; 206 (4): 504-11.

23. Petersen E.E, Genet M, Caserini M, Palmieri R. Efficacy of vitamin C vaginal tablets in the treatment of bacterial vaginosis: a randomised, double blind, placebo controlled study. Arzneimit-telforschung. 2011; 61 (4): 260-5.

24. Vanrompay D., Hoang T.Q., De Vos L. et al. Specific-pathogen-free pigs as an animal model for studying Chlamydia trachomatis genital infection. Infect. Immunol. 2005; 73 (12): 8317–21.

25. Walker P. et al. International terminology of colposcopy: an updated report from the International Federation for cervical pathology and colposcopy. Obstet. and Gynecol. 2003; 101 (1): 1775-1777.


For citation:


Mikheeva Y.V., Khvorostukhina N.F., Novichkov D.A. A MODERN APPROACH TO THE TREATMENT OF COMPLICATED ECTOPIA OF THE CERVIX. Obstetrics, Gynecology and Reproduction. 2016;10(2):24-31. (In Russ.) https://doi.org/10.17749/2313-7347.2016.10.2.024-031

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ISSN 2313-7347 (Print)
ISSN 2500-3194 (Online)