INFLUENCE OF BACTERIAL FACTORS ON DETERIORATION OF UTEROPLACENTAL PERFUSION
https://doi.org/10.17749/2313-7347.2016.10.2.005-014
Abstract
Objective: to make analysis of isolated deterioration of blood flow in the pool of uterine arteries in low-risk pregnancy after 18-week gestation, to detect connection of blood flow deterioration with infection processes of different location in the organism of pregnant women.
Methods. Doppler screening research was made as well as analysis of spectrograms of uteroplacental and fetal blood flow of 357 pregnant women.
Results. Low-risk pregnancy was accompanied by high frequency of hyperdynamic deterioration in the system of "mother-placenta-fetus" (14%), most frequently was detected the reduction of perfusion data of uteroplacental blood flow (67,9%) with almost absolute dominance (prevalence) of one-sided deterioration; high correlation dependence was revealed between reduction of uteroplacental blood flow and existence of extragenital chronic infection foci (71,4%); asymptomatic bacteriuria and infection-and-inflammatory disease of laryngological organs; causal treatment improved hemodynamic rates, with idiopathic forms of uteroplacental perfusion deterioration, pathogenic treatment is recommended, dipyridamol – 75 mg daily (25 mg three times a day) is a chosen medicine.
Conclusion. Isolated one-sided deterioration of uteroplacental blood flow during low-risk pregnancy may be considered as the mark of chronic infection foci in the body of a pregnant woman; well-timed diagnostics and causal treatment allow to avoid progressive deterioration of hemodynamic rate.
About the Authors
V. A. Kaptilnyy
First Moscow State Medical Sechenov University of the Ministry of Health Russian Federation
Russian Federation
Russian Federation
PhD, leading researcher, assistant of the Department of Obstetrics and Gynecology, Medical Faculty №1,
ul. Trubeckaja, 8-2, Moscow, 119991
M. V. Berishvili
First Moscow State Medical Sechenov University of the Ministry of Health Russian Federation
Russian Federation
Russian Federation
PhD, docent of the Department of Obstetrics and Gynecology, Medical Faculty №1,
ul. Trubeckaja, 8-2, Moscow, 119991
I. M. Krasilshhikov
First Moscow State Medical Sechenov University of the Ministry of Health Russian Federation
Russian Federation
Russian Federation
4th year student, Medical Faculty №1,
ul. Trubeckaja, 8-2, Moscow, 119991
D. V. Lyscev
First Moscow State Medical Sechenov University of the Ministry of Health Russian Federation
Russian Federation
Russian Federation
4th year student, Medical Faculty №1,
ul. Trubeckaja, 8-2, Moscow, 119991
References
1. Ageeva M.I. Doppler studies in obstetric practice [Dopplerometricheskie issledovanija v akusherskoj praktike]. Moscow. 2000; 112 s.
2. Antonov V.F., Chernysh A.M., Kozlova E.K. Medical and biological physics [Medicinskaja i biologicheskaja fizika]. Moscow. 2013; 648 s.
3. Blinov D.V., Sandukovskaja S.I. Epilepsiya i paroksizmal'nye sostoyaniya / Epilepsy and paroxysmal conditions. 2010; 4: 12-22.
4. Gudmundsson S. Ul'traz. diag. v akush., ginekol. i pediatr. 1994; 1: 15-25.
5. Demidov B.S., Voronkova M.A. Ul'trazvuk. diagnost. v akush., ginek. i pediatr. 1994; 3: 48-53.
6. Dzhobava Je.M., Nekrasova K.R., Artizanova D.P., Hejdar L.A., Sudakova G.Ju., Daneljan S. Zh., Blinov D.V., Dobrohotova Ju.Je. Akusherstvo, ginekologiya i reproduktsiya / Obstetrics, gynecology and reproduction. 2013; 1: 45-53.
7. Дижевская Е.В. Akusherstvo, ginekologiya i reproduktsiya / Obstetrics, gynecology and reproduction. 2015; 3: 68-85.
8. Zaharova E.I., Brill' G.E. Jeksperimental'naja i klinicheskaja farmakologija. 1998; 4; 54-56. 9. Zelenjuk B.I., Adamjan L.V., Murvatov K.D., Obel'chak I.S. Zemskij vrach. 2012; 6 (17): 24-26.
9. Kac Ja.A., Parhonjuk E.V., Akimova N.S. Fundamental'nye issledovanija. 2013; 5 (1): 189-195.
10. Korotjaev A.I. Babichev S.A. Medical microbiology, immunology and virology. 5th
11. ed. [Medicinskaja mikrobiologija, immunologija i virusologija. 5-e izd]. Moscow. 2012. 760 s.
12. Makarov O.V., Volkova E.V., Lysjuk E.Ju., Kopylova Ju.V. Akusherstvo, ginekologiya i reproduktsiya / Obstetrics, gynecology and reproduction. 2013; 3: 13-19.
13. Medvedev M.V., Kur'jak A., Judina E.V. Doppler in obstetrics. A Practical Guide [Dopplerografija v akusherstve. Prakticheskoe rukovodstvo]. Moscow. 1999; 160 s.
14. Medvedev M.V. Doppler examination uteroplacental and fetal circulation [Dopplerograficheskoe issledovanie matochnoplacentarnogo i plodovogo krovotoka].
15. Moscow. 1996; II: 256-279.
16. Mit'kov V.V. Clinical guidelines for ultrasound diagnostics [Klinicheskoe rukovodstvo po ul'trazvukovoj diagnostike]. T. 2. 1996; 257-275.
17. New features assess arterial stiffness – an early marker of cardiovascular diseases. Proceedings of the symposium [Novye vozmozhnosti ocenki arterial'noj rigidnosti – rannego markera razvitija serdechno-sosudistyh zabolevanij. Materialy simpoziuma]. Moscow. 2007; 48s.
18. Ohapkin M.B. i soavt. Ul'trazvuk. diagn. v akush., ginek. i pediatrii. 1993; 1: 42-45.
19. Perederjaeva E.B., Pshenichnikova T.B., Andreeva M.D., Makacarija A.D. Akusherstvo, ginekologiya i reproduktsiya / Obstetrics, gynecology and reproduction. 2015; 3: 54-65.
20. Rozenfel'd B.E. Ul'trazvuk. diagnostika. 1995; 3: 21-26.
21. Sidorova I.S. i soavt. Rossijskij vestnik perinatologii i pediatrii. 1995; 4: 14-18.
22. Sidorova I.S., Unanjan A.L., Nikitina N.A., Rzaeva A.A., Kinjakin V.V. Akusherstvo, ginekologiya i reproduktsiya / Obstetrics, gynecology and reproduction. 2012; 4: 29-32.
23. Sterin Dzh. Vest. Secrets of Rheumatology [Sekrety revmatologii]. Moscow. 1999; 758 s.
24. Strizhakov A.N. Akush. i ginek. 1993; 3: 12-14.
25. Basic and clinical physiology. Ed. A. Kamkina and Kamenskii [Fundamental'naja i klinicheskaja fiziologija. Pod red. A. Kamkina i A. Kamenskogo]. Moscow. 2004; 1080 s.
26. Shal'kevich L.V., L'vova O.A., Dron' A.N. Epilepsiya i paroksizmal'nye sostoyaniya / Epilepsy and paroxysmal conditions. 2014; 3: 30-37.
27. Albu A., Anca A., Horhoianu V., Horhoianu I. Predictive factors for intrauterine growth restriction. J Med Life. 2014 Jun 15; 7 (2): 165-171. Epub 2014 Jun 25.
28. Barati M., Shahbazian N., Ahmadi L., Masihi S. Diagnostic evaluation of uterine artery Doppler sonography for the prediction of adverse pregnancy outcos. J Res Med Sci. 2014. Jun; 19 (6): 515-9.
29. Bissell D.M., Friedman S.L., Maher J.J., Roll F.J. Connective fissue biology and hepatic fibrosis: Report of a conference. Hepatology. 1990; 11 (3): 488-498.
30. Crovetto F., Figueras F., Triunfo S., Crispi F., Rodriguez-Sureda V., Dominguez C., Llurba E., Gratacós E. First trimester screening for early and late preeclampsia based on maternal characteristics, biophysical parameters, and angiogenic factors. Prenat Diagn. 2014 Oct 24; doi: 10.1002.
31. Ebrashy A., Ibrahim M., Marzook A., Yousef D. Usefulness of aspirin therapy in high-risk pregnant women with abnormal uterine artery Doppler ultrasound at 14-16 weeks pregnancy: randomized controlled clinical trial. Croat Med J. 2005 Oct; 46 (5): 826-31.
32. First-trimester uterine artery Doppler and adverse pregnancy outcome: a meta-analysis involving 55,974 women. Ultrasound Obstet Gynecol. 2014 May; 43 (5): 500-7. doi: 10.1002/uog.13275. Epub 2014 Apr 4.
33. Li N., Ghosh G., Gudmundsson S. Uterine artery Doppler in high-risk pregnancies at 23-24 gestational weeks is of value in predicting adverse outcome of pregnancy and selecting cases for more intense surveillance. Acta Obstet Gynecol Scand. 2014 Dec; 93 (12): 1276-81. doi: 10.1111/ aogs.12488. Epub 2014 Sep 21.
34. Nicolaides K., Rizzo G., Hecher K., Ximenes R. Doppler in Obstetrics 2002 by The Metal Medicine Foundation. URL: https://fetalmedicine.org/var/uploads/Doppler-in-Obstetrics.pdf. Epub 2014 Sep 21.
35. Talari H., Mesdaghinia E., Abedzadeh Kalahroudi M. Aspirin and preeclampsia prevention in patients with abnormal uterine artery blood flow. Iran Red Crescent Med J. 2014 Aug; 16 (8): e17175. doi: 10.5812/ ircmj.17175. Epub 2014 Aug 5.
Review
For citations:
Kaptilnyy V.A., Berishvili M.V., Krasilshhikov I.M., Lyscev D.V. INFLUENCE OF BACTERIAL FACTORS ON DETERIORATION OF UTEROPLACENTAL PERFUSION. Obstetrics, Gynecology and Reproduction. 2016;10(2):5-14. (In Russ.) https://doi.org/10.17749/2313-7347.2016.10.2.005-014
Views: 580
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
Email this article 
