Personalized medicine in gynecology and obstetrics: new diagnostic and therapeutic strategies
https://doi.org/10.17749/2313-7347/ob.gyn.rep.2025.637
Abstract
This journal issue presents studies in the field of obstetrics, gynecology and reproductive medicine. The original articles consider the genetic aspects of preeclampsia, including the role of NOS3 gene rs1799983 polymorphism, modern approaches for predicting uterine fibroids using neural network technologies, and vasopressin value as a marker of premature birth. Particular attention is paid to personalized methods of treating coagulopathic bleeding based on thromboelastometry and pregnancy management in chronic kidney pathology. The review articles analyze the pharmacological properties of iron fumarate, the role of the ARID1A gene in gynecological oncology, microbiome impact on the effectiveness of assisted reproductive technologies and the pathogenesis of fetal inflammatory syndrome. Clinical observation describes a rare case of spontaneous uterine rupture, and a historical analysis of forgotten obstetric techniques is presented.
Keywords
preeclampsia,
NOS3 gene polymorphism,
venous thrombosis,
uterine fibroids,
neural network analysis,
premature birth,
vasopressin,
chronic kidney disease,
coagulopathic bleeding,
thromboelastometry,
ferrous fumarate,
microbiome,
assisted reproductive technologies,
ARID1A gene,
fetal inflammatory syndrome,
uterine rupture
About the Authors
A. D. Makatsariya
Sechenov University
Russian Federation
Russian Federation
Alexander D. Makatsariya, MD, Dr Sci Med, Prof., Academician of RAS
Scopus Author ID: 57222220144
WoS ResearcherID: M-5660-2016
8 bldg. 2, Trubetskaya Str., Moscow 119048
A. V. Vorobev
Sechenov University
Russian Federation
Russian Federation
Alexander V. Vorobev, MD, PhD
Scopus Author ID: 57191966265
WoS ResearcherID: F-8804-2017
8 bldg. 2, Trubetskaya Str., Moscow 119048
References
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Review
For citations:
Makatsariya A.D., Vorobev A.V. Personalized medicine in gynecology and obstetrics: new diagnostic and therapeutic strategies. Obstetrics, Gynecology and Reproduction. 2025;19(2):152-157. (In Russ.) https://doi.org/10.17749/2313-7347/ob.gyn.rep.2025.637
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