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Objective. To highlight the modern views on the approaches to the treatment of infertility in endometriosis ovaries. Subject and methods. A review of 30 domestic and foreign sources, on the problem of endometriosis included in the PUBMED and Russian Science Citation Index database. Results. Endometriosis should be treated as a chronic disease that requires long-term development plan for the management of patients in order to maximize the use of drug treatment and elimination of repeated surgical interventions. Using the most gentle tactics of surgical treatment and allow the use of agonists of gonadotropin-releasing hormone preserve ovarian reserve of women of reproductive age and contribute to pregnancy. Conclusion. Given the complexity and controversial nature of many issues related to the etiology, pathogenesis and treatment of endometriosis, it is necessary to develop a unified system concept of a multidisciplinary approach to the tactics of patients with this disease.

About the Authors

S. A. Gasparyan
Stavropol State Medical University
Russian Federation
MD, Professor Department of Obstetrics and Gynecology

R. M. Ionova
Stavropol State Medical University
Russian Federation
PhD, Assistant Professor, Department of Obstetrics and Gynecology

O. S. Popova
Stavropol State Medical University
Russian Federation
postgraduate student, Department of Obstetrics and Gynecology

A. A. Khripunova
Stavropol State Medical University
Russian Federation
Ph.D., Associate Professor, Department of Public Health, Public Health Service and Medical Informatics


1. Adamyan L.V., Gasparyan S.A. Genital endometriosis. The modern view on the problem [Genital'nyi endometrioz. Sovremennyi vzglyad na problem (In Russian)]. Stavropol. 2004; 228 s.

2. Davydov A.I., Chaban O.V. Onkoginekologiya. 2012; 2: 39-48.

3. Endina A.V., Gladilin G.P. Fundamental'nye issledovaniya. 2013; 7-1: 87-90.

4. Zholobova M.N., Vedernikova N.V., Rannev I.B., Ageev M.B., Kovaleva A.M. Rossiiskii vestnik akushera-ginekologa. 2012; 3: 102.

5. Ishchenko A.I., Kudrina E.A. Endometriosis. Contemporary aspects [Endometrioz. Sovremennye aspekty (In Russian)]. Moscow. 2008; 176 s.

6. Krasnopol'skii V.I., Gorskii S.L. Rossiiskii vestnik akushera-ginekologa. 2009; 9 (5): 60-63.

7. Proceedings of the Russian-language section I of the European Congress "Endometriosis in the XXI century" [Materialy russkoyazychnoi sektsii I Evropeiskogo kongressa «Endometrioz v XXI veke» (In Russian)]. Moscow. 2012; 11 s.

8. Musaev R.D, Chaban O.V, Davydov A.I. Voprosy ginekologii, akusherstva i perinatologii. 2011; 10 (5): 5-11.

9. Popov A.A., Ramazanov M.R., Koval' A.A., Chanturiya T.Z. 1-i Rossiiskii vestnik akusheraginekologa. 2013; 13 (3): 96-98.

10. Samykina O.V., Mel'nikov V.A., Skvorchevskaya S.A. Fundamental'nye issledovaniya. 2013; 3 (1): 114-116.

11. Saprykina L.V., Dobrokhotova Yu.E., Saprykina O.A. Akusherstvo i ginekologiya. 2015; 3: 10-14.

12. Trushkevich O.O., Mysenko O.D., Dovgan' A.A., Stepur A.A. Zdorov'e zhenshchiny. 2014; 5(91): 119.

13. Chuprynin V.D., Mel'nikov M.V., Buralkina N.A. et al. Akusherstvo i ginekologiya. 2015; 11: 16-22.

14. Shestakova I.G. StatusPraesens. 2014; 1(18): 65-72.

15. Endometriosis: Diagnosis, treatment and rehabilitation. Clinical guidelines. Ed. LV Adamyan [Endometrioz: diagnostika, lechenie i reabilitatsiya. Klinicheskie rekomendatsii]. Pod red. L.V. Adamyan (In Russian)]. Moscow. 2013; 86 c.

16. Consensus on current management of endometriosis Neil P. Johnson and Lone Hummelshoj1, for the World Endometriosis Society Montpellier Consortium Hum. Reprod. Advance Accesspublished. March 25, 2013.

17. Donnez J., Nisolle M., Casanas-Roux F. et al. Endometri osis rati onal for surgeri. The current status of endometriosis. 1993; 385-395.

18. Donnez J., Nisolle M. Laparoscopic menegment of large ovarian endometrial cysts. J. Gynecol. Surg. 1991; 7: 163-167.

19. Garcia-Velasco, Somigliana E. Management of endometriomas in woman requiring IVF: to touch or not to touch. Hum. Reprod. 2009; 24 (3): 496-501.

20. Harb H.M. The effect of endometriosis on in vitro fertilisation outcome: a systematic review and meta-analysis. BJOG. 2013 Oct; 120 (11): 1308-20.

21. Jee B.C., Lee J.Y., Suh C.S. et al. Impact of GnRH agonist treatment on recurrence of ovarian endometriosis after conservative laparoscopic surgery. Fertil Steril. 2009: 91 (1): 40-4.

22. Lee D.Y., Bae D.S., Yoon B.K., Choi D. Postoperative cyclic oral contraceptive use after gonadotropin-releasing hormone agonist treatment effectively prevents endometrioma recurrence. Hum Reprod. 2010; 25 (12): 3050-3054.

23. Lindsay S.F., Luciano D.E., Luciano A.A. Emerging therapy for endometriosis. Expert Opin Emerg Drugs. 2015 Sep; 20 (3): 449-61. DOI: 10.1517/14728214.2015.1051966. Epub 2015 Jun 11.

24. Metzger D.A., Szpak C.A., Haney A.F. Histologic features associaeted with hormonal responsiveness of ectopic endometrium. Fertil. Steril. 1993; 5: 80-88.

25. Rogers P.A., D`Hooghe T.M., Fazeleabas A., Gargett C.E., Giudice L.S., Montgomery G.w. et al. Priorities for endometriosis research: recommendations from an International Consensus Workshop. Reprod. Sci. 2009; 16 (4): 335-46.

26. Sallam H.N. et al. Long-term pituitary downregulation before in vitro fertilization (IVF) for women with endometriosis, (review). The Cochrane collaboration. 2010.

27. Sampson J.A. Perforating hemorrhagic (chocolate) cysts of the ovary. Arch. Surg. 1991; 245-323.

28. Tosti C., Pinzauti S., Santulli P., Chapron C., Petraglia F. Pathogenetic Mechanisms of Deep Infiltrating Endometriosis. Reprod Sci. 2015 Sep; 22 (9): 1053-9. DOI: 10.1177/1933719115592713. Epub 2015 Jul 12.

29. Vercellini P., Giudice L.C., Evers J.L.H., Abrao M.S. Reducing low-value care in endometriosis between limited evidence and unresolved issues: a proposal. Hum. Reprod. 2015; 30 (9): 1996-2004.

30. Yang X.H. Effects of laparoscopic ovarian endometriosis cystectomy combined with postoperative GnRH-a therapy on ovarian reserve, pregnancy and outcome reccurence. Clin. Exp. Obstet Gynecol. 2014; 41 (3): 272-5.

31. Zeev Blumenfeld et al. Human Reproduction Update. 2008; 14 (6): 543-552.



For citations:

Gasparyan S.A., Ionova R.M., Popova O.S., Khripunova A.A. ENDOMETRIOSIS AND FERTILITY. KEY MOMENT OF TREATMENT. Obstetrics, Gynecology and Reproduction. 2015;9(4):66-72. (In Russ.)

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ISSN 2500-3194 (Online)