Preview

Obstetrics, Gynecology and Reproduction

Advanced search

MELATONIN EFFICIENCY IN MULTIPLE TREATMENT OF ABNORMAL UTERUS BLEEDING

https://doi.org/10.17749/2070-4968.2015.9.4.025-030

Full Text:

Abstract

Objective. To increase efficiency and to develop pathogenetically substantiated treatment regimen of abnormal uterine bleeding. Materials and Methods. Analysis of 96 cases of abnormal uterine bleeding among women of reproductive age with combined extragenital pathology. On the background of a standard survey further determination of hormones in the blood (cortisol), the expression of anxiety on the Hamilton Anxiety Scale. On the background of the standard hemostatic therapy in a hospital environment 48 women (group I) were additionally prescribed melatonin, 48 women (group II) were prescriebed standard treatment. Control group III - 23 healthy women. Results. The use of the drug melatonin (3 mg №2) in the treatment of abnormal uterine bleeding among women of reproductive age with combined extragenital pathology promotes considerable reduction of anxiety and the growth of cortisol level, which accelerates the formation of the adaptation syndrome, thereby increasing the effectiveness of the treatment.

About the Author

E. N. Tananakina
Theodosia Medical Center, Russia, Lugansk State Medical University, Ukraine
Russian Federation
obstetrician-gynecologis


References

1. Avakyan G.N., Oleinikova O.M., Kareva E.N., Bogomazova M.A. Epilepsiya i paroksizmal'nye sostoyaniya / Epilepsy and paroxysmal conditions. 2014; 4: 67-71.

2. Anisimov V.N. Melatonin: role in the body, the application in the clinic [Melatonin: rol' v organizme, primenenie v klinike (In Russian)]. St. Petersburg. 2007; 40 s.

3. Anisimov V.N. Russkii meditsinskii zhurnal. 2007; 25: 1915-1918.

4. Anisimov V.N. Aging of the female reproductive system and melatonin [Starenie zhenskoi reproduktivnoi sistemy i melatonin (In Russian)]. St. Petersburg. 2008; 44 s.

5. Arushanyan E.B., Beier E.V. Uspekhi fiziol. nauk. 2012; 43 (2): 82-100.

6. Bodryagova A.I. Justification differentiated treatment of dysfunctional uterine bleeding in women of late reproductive age. Phd. Diss. [Obosnovanie differentsirovannykh metodov lecheniya disfunktsional'nykh matochnykh krovotechenii u zhenshchin pozdnego reproduktivnogo vozrasta: Avtoref. dis. ... kand. med. nauk (In Russian)]. Kiev. 2008. 20 s.

7. Vdovichenko Yu.P., Shamrai V.A. Zdorov'e zhenshchiny. 2012; 1: 118-120.

8. Dimitriev D.A. Sex hormones in the regulation of the cardiovascular system: a training manual [Polovye gormony v regulyatsii deyatel'nosti serdechno-sosudistoi sistemy: ucheb. Posobie (In Russian)]. Cheboksary. 2009; 128 s.

9. Ermolaeva S.V. Pathogenetic correction of endotoxemia with dysfunctional uterine bleeding Phd. diss. [Patogeneticheskaya korrektsiya endotoksikoza pri disfunktsional'nykh matochnykh krovotecheniyakh. Avtoref. diss. …kand. med. nauk (In Russian)]. Moscow. 2010; 81 s.

10. Kaladze N.N, Soboleva E.M., Skoromnaya N.N. Zdorov'e rebenka. 2010; 2 (23): 156-166.

11. Milyutina Yu.P. Geroprotective role of peptides and pineal melatonin in the correction of the hypothalamic regulation of reproductive function. Phd. diss [Rol' geroprotektornykh peptidov pineal'noi zhelezy i melatonina v korrektsii narushenii gipotalamicheskoi regulyatsii reproduktivnoi funktsii. Diss. ... kand. biol. Nauk (In Russian)]. SPb. 2010; 138 s.

12. Oleinikova O. M., Kareva E.N., Bogomazova M.A., Avakyan G.G., Lagutin Yu.V., Avakyan G.N. Epilepsiya i paroksizmal'nye sostoyaniya / Epilepsy and paroxysmal conditions. 2011; 4: 22-27.

13. Sapronov N.S. Hormones of the hypothalamic-pituitary-ovarian system and brain [Gormony gipotalamo-gipofizarnoovarial'noi sistemy i mozg (In Russian)]. St. Petersburg. 2009; 591 s.

14. Tananakina E.N. Akusherstvo, ginekologiya I reproduktsiya / Obstetrics, gynecology and reproduction. 2014; 3: 31-38.

15. Tatarchuk T.F., Shevchuk T.V., Ivasyuk E.I. Zdorov'e zhenshchiny. 2009; 42 (6): 17-18.

16. Tatarchuk T.F., Kosei N.V., Tutchenko T.N., Kapshuk I.N. Reproduktivnaya endokrinologiya. 2012. 1 (3): 74-78.

17. Tatarchuk T.F. Genderna meditsina. 2010; 2: 78-88.

18. Shcherbatykh Yu.V. Psychology of stress [Psikhologiya stressa (In Russian)]. Moscow. 2008; 304 s.

19. Shcherbatykh Yu.V. Psychology of stress and methods of correction [Psikhologiya stressa i metody korrektsii]. St. Petersburg. 2007; 256 s.

20. Yaglov V.V. Reproduktivnoe zdorov'e zhenshchiny. 2007; 9 (6): 25-29.

21. Jung B., Ahm ad N. Melatonin in cancer management: progress and promise. Cancer Res. 2006; 15: 9789-9793.

22. Yasuo S., Yoshimura S., Ebihara H.W. Melatonin transmits photoperiodic signals through the MT1 melatonin receptor. J. Neurosci. 2009; 29: 2885-2889.

23.

24.


For citation:


Tananakina E.N. MELATONIN EFFICIENCY IN MULTIPLE TREATMENT OF ABNORMAL UTERUS BLEEDING. Obstetrics, Gynecology and Reproduction. 2015;9(4):25-30. (In Russ.) https://doi.org/10.17749/2070-4968.2015.9.4.025-030

Views: 70


ISSN 2313-7347 (Print)
ISSN 2500-3194 (Online)