FEATURES PERITONEAL FACTORS IN EXTERNAL GENITAL ENDOMETRIOSIS

S. V. Barinov; E. I. Novikova; D. G. Novikov; A. V. Indutny; L. N. Vasilenko

doi:10.17749/2070-4968.2015.9.4.018-024

FEATURES PERITONEAL FACTORS IN EXTERNAL GENITAL ENDOMETRIOSIS

S. V. Barinov, E. I. Novikova, D. G. Novikov, A. V. Indutny, L. N. Vasilenko

https://doi.org/10.17749/2070-4968.2015.9.4.018-024

Full Text:

PDF (Rus)

Abstract

Objective. To determine the diagnostic value of the concentration of cytokines and growth factors contained in the biological fluids of patients with external genital endometriosis (EGE). Materials and Methods. Clinical data were evaluated and the concentration of IL-1 β, IL-6, IL-8, IL-10, α 2-macroglobulin, vascular endothelial growth factor (VEGF) in 18 patients with EGE. Results. Significant differences were found between the concentration of the studied markers in venous blood and peritoneal fluid (PF). We found a relationship between pain of patients with EGE and the concentration of IL-10 (r=0,480 p=0,135), VEGF (r=0,478 p=0,277) and α 2-macroglobulin in the PF (r=0,554, p=0,049). The dependence between the concentration of IL-6 in the PF and the prevalence of pathological process in EGE (r=0,560, p=0,005). We found significant increase of the concentration VEGF in the PF of patients with EG compared with the control group. Conclusion. The data obtained allow the use of research concentration of markers in the peritoneal fluid of patients with EGE to predict the future course of the disease.

Keywords

External genital endometriosis, peritoneal fluid, pain, cytokines, VEGF

About the Authors

S. V. Barinov

Omsk State Medical University
Russian Federation
MD, Professor, Head of the department of Obstetrics and Gynecology № 2

E. I. Novikova

Omsk State Medical University
Russian Federation
a graduate student Department of Obstetrics and Gynecology number 2

D. G. Novikov

Omsk State Medical University
Russian Federation
PhD, Head of the Central Scientific Research Laboratory

A. V. Indutny

Omsk State Medical University
Russian Federation
MD, Head of the department of laboratory diagnostics

L. N. Vasilenko

Clinical medical hospital № 9
Russian Federation
PhD, Head of the department of Gynecology № 2

References

1. Adamjan L.V., Kulakov V.I. Endometriosis: A Guide for Physicians [Jendometriozy: rukovodstvo dlja vrachej (In Russian)]. Moscow. 2006; 320 s.

2. Burlev V.A., Dubinskaja E.D., Il'jasova N.A., Gasparov A.S., Burlev A.V. Problemy reprodukcii. 2011; 4: 10-18.

3. Zorin N.A., Zorina V.N. Biomedicinskaja himija. 2012; 58 (4), 400-10.

4. Ishhenko A.I., Kudrina E.A. Endometriosis: Modern Aspects [Jendometrioz: sovremennye aspekty (In Russian)]. Moscow. 2008: 176.

5. Kononov A.V., Mozgovoj S.I., Mozgovaja E.I., Novikov D.G. Omskij nauchnyj vestnik. 2008; 1 (65): 32-6.

6. Linde V.A., Tatarova N.A., Lebedeva N.E., Grishanina O.I. Problemy reprodukcii. 2008; 3: 68-72.

7. Loginova O.N., Sonova M.M. Akusherstvo, ginekologiya i reproduktsiya / Obstetrics, gynecology and reproduction. 2011; 3: 5-9.

8. Orazov M.R., Chaika A.V., Nosenko E.N. Akusherstvo, ginekologiya i reproduktsiya / Obstetrics, gynecology and reproduction. 2014; 3: 6-10.

9. Solodovnikova N.G., Niauri D.A. Vestnik SPbGU. 2006; 2. 115-22.

10. Unanjan A.L. Akusherstvo, ginekologiya i reproduktsiya / Obstetrics, gynecology and reproduction. 2010; 3: 6-11.

11. Unanyan A.L., Alimov V.A., Arakelov S.E., Afanas'ev M.S., Baburin D.V., Blinov D.V., Guriev T.D., Zimovina U.V., Kadyrova A.E., Kossovich Yu.M., Polonskaya L.S. FARMAKOEKONOMIKA. Sovremennaya farmakoekonomika i farmakoepidemiologiya / PHARMACOECONOMICS. Modern pharmacoeconomics and pharmacoepidemiology. 2014; 7 (3): 44-50.

12. Cherkasova N.Yu., Fomina A.V., Filippova O.V. FARMAKOEKONOMIKA. Sovremennaya farmakoekonomika i farmakoepidemiologiya / PHARMACOECONOMICS. Modern pharmacoeconomics and pharmacoepidemiology. 2013; 6 (3): 36-39.

13. Capobianco A., Rovere-Querini P. Endometriosis, a disease of the macrophage. Front Immunol. 2013; 4: 9.

14. Deal L.S., Di Benedetti D.B., Williams V.S., Fehnel S.E. The development and validation of the daily electronic Endometriosis Pain and Bleeding Diary. Health Qual Life Outcomes. 2010; 2 (8): 64.

15. Domagala-Kulawik J. The role of the immune system in non-small cell lung carcinoma and potential for therapeutic intervention. Transl Lung Cancer Res. 2015; 4 (2): 177-90.

16. Gurian M.B., Mitidieri A.M., Rosa E., Silva J.C., Poli Neto O.B., Nogueira A.A., Candido Dos Reis F.J. Measures Used to Assess Chronic Pelvic Pain in Randomized Controlled Clinical Trials: A Systematic Review. J Eval Clin Pract. 2015; Epub a head of print.

17. Kicielinska J., Pajtasz-Piasecka E. The role of IL-10 in the modulation of the immune response in normal conditions and the tumor environment. Postepy Hig Med Dosw (Online). 2014; 68: 879-92.

18. Kianpour M., Nematbakhsh M., Ahmadi S.M., Jafarzadeh M., Hajjarian M., Pezeshki Z., Safari T., Eshraghi-Jazi F. Serum and peritoneal fluid levels of vascular endothelial growth factor in women with endometriosis. Int J Fertil Steril. 2013; 7 (2): 96-9.

19. Lv D., Song H., Shi G. Anti-TNF-alpha treatment for pelvic pain associated with endometriosis. Cochrane Database Syst Rev. 2010; (3): CD008088.

20. Panel P., Renouvel F. Management of endometriosis: clinical and biological assessment. J Gynecol Obstet Biol Reprod (Paris). 2007; 36 (2): 119-28.

21. Papanicolaou D.A., Petrides J.S, Tsigos C., Bina S., Kalogeras K.T., Wilder R. et al. Exercise stimulates interleukin-6 secretion: inhibition by glucocorticoids and correlation with catecholamines. Am J Physiol. 1996; 271 (3): 601-5.

22. Rizner T.L. Diagnostic potential of peritoneal fluid biomarkers of endometriosis. Expert Rev Mol Diagn. 2015; 15 (4): 557-80.

23. Selcuk I., Bozdag G. Recurrence of endometriosis; risk factors, mechanisms and biomarkers; review of the literature. J Turk Ger Gynecol Assoc. 2013; 14 (2): 98-103.

24. Stull D.E., Wasiak R., Kreif N., Raluy M., Colligs A., Seitz C., Gerlinger C. Validation of the SF-36 in patients with endometriosis. Qual Life Res. 2014; 23 (1): 103-17.

25. Vercellini P., Fedele L., Aimi G., Pietropaolo G., Consonni D., Crosignani P.G. Association between endometriosis stage, lesion type, patient characteristics and severity of pelvic painsymptoms: a multivariate analysis of over 1000 patients. Hum Reprod. 2007; 22 (1): 266-71.

26. Varma R., Rollason T., Gupta J.K., Maher E.R. Endometriosis and the neoplastic process. Reproduction. 2004; 127 (3): 293-304.

27. Wickiewicz D., Chrobak A., Gmyrek G.B., Halbersztadt A., Gabryś M.S., Goluda M. et al. Diagnostic accuracy of interleukin-6 levels in peritoneal fluid for detection of endometriosis. Arch Gynecol Obstet. 2013; 288 (4): 805-14.

28. Yeo S.G., Won Y.S., Lee H.Y., Kim Y.I., Lee J.W., Park D.C. Increased Expression of Pattern Recognition Receptors and Nitric Oxide Synthase in Patients with Endometriosis. Int J Med Sci. 2013; 10 (9): 1199-208.

29.

30.

For citation:

Barinov S.V., Novikova E.I., Novikov D.G., Indutny A.V., Vasilenko L.N. FEATURES PERITONEAL FACTORS IN EXTERNAL GENITAL ENDOMETRIOSIS. Obstetrics, Gynecology and Reproduction. 2015;9(4):18-24. (In Russ.) https://doi.org/10.17749/2070-4968.2015.9.4.018-024