Preview

Obstetrics, Gynecology and Reproduction

Advanced search

CIRCULATION OF ANTIPHOSPHOLIPID ANTIBODIES AND IVF FAILURES

https://doi.org/10.17749/2070-4968.2015.9.3.006-010

Full Text:

Abstract

The antiphospholipid antibodies (APA) exert multiple effects on the hemostasis system causing damage to all of its protective components including the endothelial barrier, natural anticoagulant function and endogenous fibrinolysis and activating the platelet of hemostasis, which is associated with numerous obstetrical complications and infertility. Objective. This study aimed at elucidating the effect of the presence of APA on the outcomes of assisted reproductive technology (ART). Materials and Methods. A total of 217 women diagnosed with infertility and planning to get pregnant using the assisted reproductive technology (ART) have been examined. Results. The results of examination demonstrated a high prevalence of circulating APA in a group of women underwent IVF failure. Conclusion. The thrombophilia can be one of the reasons of failures of in-vitro fertilization.

About the Authors

N. S. Stuleva
First Moscow State Medical Sechenov University
Russian Federation
PhD, Head of the Department “Clinical hemostasis”


D. K. Khizroeva
First Moscow State Medical Sechenov University
Russian Federation

PhD, Department of Obstetrics and Gynecology, Faculty of Medical and Preventive



T. Y. Mashkova
First Moscow State Medical Sechenov University
Russian Federation
graduate student of the department of obstetrics and gynecology medical-prophylactic faculty


G. R. Abramyan
Yerevan State Medical University after Mkhitar Heratsi
Armenia
research scientist


References

1. APASS Investigators. Antiphospholipid antibodies and subsequent thrombo-occlusive events in patients with Ischemic Stroke. JAMA.2004; 291: 576-584.

2. Asherson R.A., Cervers R., Piette J.C., Shoenfeld Y. The Antiphospholipid syndrome II. Autoimmune thrombosis. Netherlands. 2002; 457 p.

3. Brenner B. Haemostatic changes in pregnancy. Thromb. Res. 2004; 114 (5-6): 409-414.

4. Bitsadze V.O., Makatsariya A.D., Hizroyeva D. H. et al. Thrombophilia as a most important link in the pathogenesis of pregnancy complications. Practical medicine. 2012; 5: 22-29.

5. Chan W.S., Dixon M.N. The “ART” of thromboembolism: a review of assisted reproductive technology and thromboembolic complications. Thromb.Res. 2008; 121 (6): 713-726.

6. Di Simone N., Meroni P.L., del Papa N., Raschi E., Caliandro D., De Carolis C.S., Kamashta M.A., Atsumi T., Hughes G.R., Balestrieri G. et al. Antiphospholipid antibodies affect trophoblast gonadotropin secretion and invasiveness by binding directly and through adhered beta2-glycoprotein 1. Arthiritis Rheum. 2000; 43: 140-150.

7. Di Simone N., Ferrazzani S., Castellani R., De Carolis C.S., Manscuso S. and Caruso A. Heparin and low dose aspirin restore placental human chorionic gonadotropin secretion abolished by antiphospholipid antibody containing sera. Hum. Reprod. 1997; 12: 2061- 2065.

8. Frankline R.D., Kutteh W.H. Antiphospholipid antibodies (APA) and reccurent pregnancy loss: treating a unique APA positive population. Hum. Reprod. 2002; 17: 2981-2985.

9. Kovac M., Mitic G. et al. Thrombophilia in women with pregnancy-associated complications: fetal loss and pregnancy-related venous thromboembolism. Gynecol.Obstet. Invest. 2010; 69 (4): 233-8.

10. Marcello de Nisio, Anne WS Rutjies, Noemi Ferrante,Gian Mario Tibony, Franco Cuccurullo, Ettore Porreca. Thrombophilia and outcomes of assisted reproduction technologies: a systematic review and meta-analysis. Blood. June 2011; 2670-78.

11. Nelson S.M., Greer I.A. The potential role of heparin in assisted conception. Hum. Reprod. Update. 2008 Nov-Dec; 14 (6): 623-645.

12. Qublan H.S., Eid S.S., Ababneh H.A., Amarin Z.O., Smadi A.Z.,Al-Khafaji F.F., Khader Y.S.Acquired and inherited thrombophilia: implication in recurrent IVF and embryo transfer failure. Hum Reprod. 2006 Oct; 21 (10): 2694-8.

13. Rudakova E.B., Besman I.V. Auxiliary reproductive technologies. Problems of losses of pregnancy. Attending Physician. 2010; 3: 46-48.


For citation:


Stuleva N.S., Khizroeva D.K., Mashkova T.Y., Abramyan G.R. CIRCULATION OF ANTIPHOSPHOLIPID ANTIBODIES AND IVF FAILURES. Obstetrics, Gynecology and Reproduction. 2015;9(3):6-10. (In Russ.) https://doi.org/10.17749/2070-4968.2015.9.3.006-010

Views: 218


ISSN 2313-7347 (Print)
ISSN 2500-3194 (Online)