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The antiphospholipid antibodies (APA) exert multiple effects on the hemostasis system causing damage to all of its protective components including the endothelial barrier, natural anticoagulant function and endogenous fibrinolysis and activating the platelet of hemostasis, which is associated with numerous obstetrical complications and infertility. Objective. This study aimed at elucidating the effect of the presence of APA on the outcomes of assisted reproductive technology (ART). Materials and Methods. A total of 217 women diagnosed with infertility and planning to get pregnant using the assisted reproductive technology (ART) have been examined. Results. The results of examination demonstrated a high prevalence of circulating APA in a group of women underwent IVF failure. Conclusion. The thrombophilia can be one of the reasons of failures of in-vitro fertilization.

About the Authors

N. S. Stuleva
First Moscow State Medical Sechenov University
Russian Federation
PhD, Head of the Department “Clinical hemostasis”

D. K. Khizroeva
First Moscow State Medical Sechenov University
Russian Federation

PhD, Department of Obstetrics and Gynecology, Faculty of Medical and Preventive

T. Y. Mashkova
First Moscow State Medical Sechenov University
Russian Federation
graduate student of the department of obstetrics and gynecology medical-prophylactic faculty

G. R. Abramyan
Yerevan State Medical University after Mkhitar Heratsi
research scientist


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For citations:

Stuleva N.S., Khizroeva D.K., Mashkova T.Y., Abramyan G.R. CIRCULATION OF ANTIPHOSPHOLIPID ANTIBODIES AND IVF FAILURES. Obstetrics, Gynecology and Reproduction. 2015;9(3):6-10. (In Russ.)

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ISSN 2313-7347 (Print)
ISSN 2500-3194 (Online)