Assessment individualization of a hormonal profile of patients with endocrine forms of infertility at the preparation for IVF
Abstract
Questions of inspection and preparation of married couples with infertility before the application of auxiliary genesial technologies (AGT) remain extremely relevant taking into account the difficult obstetric and gynecologic status of patients belonging to programs of extracorporal fertilization, age, condition of their somatic and psychological health, and also the variety of etiological and pathogenetic factors of infertility. Objective: to determine individual algorithm of the hormonal profile assessment of genesial system for women with infertility, chronic anovulation and implications of hyper-androgyny. Materials and methods. the examined patients passed complex examination of the hormonal profile of genesial system including blood test at the 3-5th and 21-23rd day of the cycle, US monitoring of the follicular apparatus and endometrium. Conclusion. as a result of stage-by-stage inspection of patients with infertility and the adequate individually selected medicamental therapy for correction of disturbances of a menstrual cycle at the preparation for IVF, pregnancy comes in 67% of cases.
About the Author
O. a. Monastyrnaya
First Moscow State Medical Sechenov University of the Ministry of Health Russian Federation
Russian Federation
PhD student Department of Obstetrics and Gynecology, Faculty of Medical and Preventive
Russian Federation
PhD student Department of Obstetrics and Gynecology, Faculty of Medical and Preventive
References
1. Vikhlyaeva E.M. Guide gynecological endocrinology [Rukovodstvo po ginekologicheskoi endokrinologii]. Moscow. 1997.
2. Vorob’eva E.V. Evaluation of the reproductive system to optimize the treatment principles of endocrine forms of infertility in women of late reproductive age. PhD. Diss. [Otsenka sostoyaniya reproduktivnoi sistemy v optimizatsii printsipov lecheniya endokrinnykh form besplodiya u zhenshchin pozdnego reproduktivnogo vozrasta. Dis. …kand. med. nauk]. Moscow. 2012; 187.
3. Guseinova Z.S. Features preventing fetal loss syndrome in women with hyperandrogenism. PhD. Diss. [Osobennosti profilaktiki sindroma poteri ploda u beremennykh s giperandrogeniei]. Dis. …kand. med. nauk. Moscow. 2011; 186.
4. Krasnopol’skaya K.V. In vitro fertilization in treatment of infertility in women. Doct. Diss. [Ekstrakorporal’noe oplodotvorenie v kompleksnom lechenii zhenskogo besplodiya. Dis. dokt. med. nauk]. Moscow. 2003; 304.
5. Kulakov V.I., Lopatina T.V. Reproductive health of the Russian population. In the book.: infertile marriages. Guide for physicians. Ed. V.I. Kulakov [Reproduktivnoe zdorov’e naseleniya Rossii. V kn.: Besplodnyi brak. Rukovodstvo dlya vrachei. Pod. red. V.I. Kulakova]. Moscow. 2006; 10-18.
6. Kulakov V.I., Nazarenko T.A., Kuzmichev L.N. i dr. Zhurnal ros. akushera i ginekologa. 2004; 1: 23-28.
7. Momot A.P., Molchanova I.V., Semenova N.A., Tomilina O.P., Elykomov V.A., Borisova O.G. FARMAKOEKONOMIKA. Sovremennaya farmakoekonomika i farmakoepidemiologiya/Pharmacoeconomics. Modern pharmacoeconomics and pharmacoepidemiology. 2013; 3: 27-30.
8. Nazarenko T.A., Durinyan E.R., Perminova S.G. Methods of assisted reproductive technology. In the book: Barren marriage. Guide for physicians. Ed. VI Kulakov [Metody vspomogatel’nykh reproduktivnykh tekhnologii. V kn: Besplodnyi brak. Rukovodstvo dlya vrachei. Pod red. V.I. Kulakova]. Moscow. 2006; 437-448.
9. Nazarenko T.A. Female infertility due to ovulation disorders: clinical features, diagnosis and treatment. Thesis Dr. diss. [Zhenskoe besplodie, obuslovlennoe narusheniyami protsessa ovulyatsii: klinika, diagnostika i lechenie. Avtoref. dis. … dokt. med. nauk]. Moscow. 1998; 42.
10. Manukhin I.B., Tumilovich L.G., Gevorkyan M.A. Clinical lectures on gynecological endocrinology [Klinicheskie lektsii po ginekologicheskoi endokrinologii]. Moscow. 2006; 174-189.
11. Pershina E.V. Evaluation and correction of violations of the principles of the reproductive system in patients with combined forms of hyperandrogenism. PhD. Diss. [Otsenka i printsipy korrektsii narushenii reproduktivnoi sistemy u bol’nykh s sochetannoi formoi giperandrogenii. Dis. …kand. med. nauk]. Moscow. 2011; 162.
12. Saidova R.A., Arutyunyan E.M., Pershina E.V., Mamardashvili R.T., Islamova Sh.N. Zhurnal akusherstva i zhenskikh boleznei. 2009; 1: 84-91.
13. Saidova R.A., Makatsariya A.D. Selected lectures on gynecology [Izbrannye lektsii po ginekologii]. Moscow. 2005; 185-208.
14. Saidova R.A., Vorob’eva E.V., Monastyrnaya O.A. Ginekologiya. 2012; 14 (2): 69-74.
15. Serov V.N., Prilepskaya V.N., Ovsyannikova T.V. Gynecological endocrinology [Ginekologicheskaya endokrinologiya]. Moscow. 2006.
16. Abstracts of the III International Congress on Reproductive Medicine [Tezisy III Mezhdunarodnogo kongressa po reproduktivnoi meditsine]. Moscow. 2009; 283-284.
17. Perminova S.G., Ter-Ovanesov G.V. Immunological infertility. In the book: Barren marriage. Guide for physicians. Ed. V.I. Kulakov [Immunologicheskoe besplodie. V kn: Besplodnyi brak. Rukovodstvo dlya vrachei. Pod red. V.I. Kulakova]. Moscow. 2006; 360-384.
18. Tkachenko E.R., Kokhlova L.Yu. Hysteroscopy as a phase of preparation for the IVF program. Problems of reproduction. Special Edition: The Second International Congress on Reproductive Medicine [Gisteroskopiya kak etap podgotovki k programmam EKO. Problemy reproduktsii. Spetsial’nyi vypusk: Vtoroi mezhdunarodnyi kongress po reproduktivnoi meditsine]. 2008.
19. Carmina E. Ovarian and adrenal hyperandrogenism. Ann. N Y Acad. Sci. 2006; 1092: 130-7.
20. Eijkemans M.J.C., Linsten A.M.E., Hunault C.C. et al. Pregnancy chances on an IVF/ICSI waiting list: a national prospective cohort study. Human Reproduction. 2008. 23 (7): 1424-1430.
21. Homburg R. Optimal protocol for ovulation induction. Updatee in Infertility Treatment. Seville, Spain. Abstract Book. 2010 Jan 27-29; 32.
22. Lopes S. Sperm deoxyribonucleic acid fragmentation is increased in poor-quality semen samples and correlates with failed fertilization in intracytoplasmic sperm injection. [et al.] Steril. 1998; 69 (3): 528-532.
23. Preliminary results on the comparison of sperm microinjection and partial zona dissection as a treatment of male factor infertility: The 7th World Congress on IVF ESHRE/ D. Sakkas [et al.]. Hum Repod. 1991; 88-88.
24. Saha L., Kaur S., Saha P.K. Pharmacotherapy of polycystic ovary syndrome: an update. Fundam. Clin. Pharmacol. 2012; 26 91): 54-62.
25. Tachibana M. et al. Towards germline gene therapy of inherited mitochondrial diseases. Nature. 2013; 493 (7434): 627-631.
For citation:
Monastyrnaya O.a. Assessment individualization of a hormonal profile of patients with endocrine forms of infertility at the preparation for IVF. Obstetrics, Gynecology and Reproduction. 2015;9(2):110-115. (In Russ.) https://doi.org/10.17749/2070-4968.2015.9.2.110-115
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